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Nrbp2 nuclear receptor binding protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 680451, updated on 6-Jun-2024

Summary

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Official Symbol
Nrbp2provided by RGD
Official Full Name
nuclear receptor binding protein 2provided by RGD
Primary source
RGD:1591749
See related
Ensembl:ENSRNOG00000029535 AllianceGenome:RGD:1591749
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including endoplasmic reticulum to Golgi vesicle-mediated transport; negative regulation of macroautophagy; and negative regulation of neuron apoptotic process. Predicted to be active in cytoplasm and endomembrane system. Orthologous to human NRBP2 (nuclear receptor binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 265.0), Lung (RPKM 167.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nrbp2 in Genome Data Viewer
Location:
7q34
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (109679330..109685656, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (107798642..107805225, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (117145106..117151694, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene scribble planar cell polarity protein Neighboring gene uncharacterized LOC102548315 Neighboring gene poly-U binding splicing factor 60 Neighboring gene epiplakin 1 Neighboring gene uncharacterized LOC134479927 Neighboring gene dystonin like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Nuclear receptor binding protein 2 is induced during neural progenitor differentiation and affects cell survival. Larsson J, et al. Mol Cell Neurosci, 2008 Sep. PMID 18619852
  2. Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. McKnight NC, et al. EMBO J, 2012 Apr 18. PMID 22354037, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of macroautophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
nuclear receptor-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001415104.1 → NP_001402033.1  nuclear receptor-binding protein 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A0G2JT23, A6HS58, D3ZA69
    Related
    ENSRNOP00000068541.1, ENSRNOT00000078846.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    109679330..109685656 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063264247.1 → XP_063120317.1  nuclear receptor-binding protein 2 isoform X1

    UniProtKB/TrEMBL
    D3ZA69

RNA

  1. XR_005486727.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001135007.1: Suppressed sequence

    Description
    NM_001135007.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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