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Chd1l chromodomain helicase DNA binding protein 1-like [ Mus musculus (house mouse) ]

Gene ID: 68058, updated on 12-May-2024

Summary

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Official Symbol
Chd1lprovided by MGI
Official Full Name
chromodomain helicase DNA binding protein 1-likeprovided by MGI
Primary source
MGI:MGI:1915308
See related
Ensembl:ENSMUSG00000028089 AllianceGenome:MGI:1915308
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Alc1; Snf2p; 4432404A22Rik
Summary
Predicted to enable nucleotide binding activity. Predicted to be involved in cellular response to DNA damage stimulus and chromatin remodeling. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in nucleus. Is expressed in genitourinary system. Orthologous to human CHD1L (chromodomain helicase DNA binding protein 1 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 13.9), bladder adult (RPKM 9.9) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Chd1l in Genome Data Viewer
Location:
3 F2.2; 3 42.17 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (97468056..97517538, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (97560740..97610222, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40101 Neighboring gene olfactory receptor family 13 subfamily L member 2 Neighboring gene STARR-seq mESC enhancer starr_08465 Neighboring gene STARR-seq mESC enhancer starr_08467 Neighboring gene STARR-seq mESC enhancer starr_08468 Neighboring gene predicted gene, 40102 Neighboring gene flavin containing monooxygenase 5 Neighboring gene STARR-positive B cell enhancer ABC_E9010 Neighboring gene protein kinase, AMP-activated, beta 2 non-catalytic subunit Neighboring gene nuclear encoded tRNA glutamine 2 (anticodon CTG) Neighboring gene predicted gene, 31242

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD. Hewitt G, et al. Mol Cell, 2021 Feb 18. PMID 33333017, Free PMC Article
  2. The chromatin remodeling factor Chd1l is required in the preimplantation embryo. Snider AC, et al. Biol Open, 2013 Feb 15. PMID 23429299, Free PMC Article
  3. Transgenic CHD1L expression in mouse induces spontaneous tumors. Chen M, et al. PLoS One, 2009 Aug 24. PMID 19701453, Free PMC Article
  4. CHD1L Regulated PARP1-Driven Pluripotency and Chromatin Remodeling During the Early-Stage Cell Reprogramming. Jiang BH, et al. Stem Cells, 2015 Oct. PMID 26201266, Free PMC Article
  5. CHD1L promotes hepatocellular carcinoma progression and metastasis in mice and is associated with these processes in human patients. Chen L, et al. J Clin Invest, 2010 Apr. PMID 20335658, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD.
    Title: Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD.
  2. overexpression of CHD1L in embryonic cells upregulated the expression of ectoderm genes, especially PAX6
    Title: CHD1L Promotes Neuronal Differentiation in Human Embryonic Stem Cells by Upregulating PAX6.
  3. found a significant correlation of CHD1L with developmental transcriptional factors and lineage differentiation markers in clinical hepatocellular carcinoma patients
    Title: CHD1L promotes lineage reversion of hepatocellular carcinoma through opening chromatin for key developmental transcription factors.
  4. these results identify CHD1L as a key chromatin remodeler involved in PARP1/PARylation-regulated early-stage reprogramming and pluripotency in stem cells.
    Title: CHD1L Regulated PARP1-Driven Pluripotency and Chromatin Remodeling During the Early-Stage Cell Reprogramming.
  5. TRIM33 plays a role in PARP-dependent DNA damage response and regulates ALC1 activity by promoting its timely removal from sites of DNA damage.
    Title: Tripartite Motif-containing 33 (TRIM33) protein functions in the poly(ADP-ribose) polymerase (PARP)-dependent DNA damage response through interaction with Amplified in Liver Cancer 1 (ALC1) protein.
  6. CHD1L promotes hepatocellular carcinoma progression and metastasis in mice and is associated with these processes in human patients.
    Title: CHD1L promotes hepatocellular carcinoma progression and metastasis in mice and is associated with these processes in human patients.
  7. our data strongly support that CHD1L is a novel oncogene and plays an important role in hepatocellular carcinoma pathogenesis
    Title: Transgenic CHD1L expression in mouse induces spontaneous tumors.
  8. Reports that transgenic CHD1L (Alc1) expression induces spontaneous tumors in mice.
    Title: Transgenic CHD1L expression in mouse induces spontaneous tumors.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP-dependent chromatin remodeler activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone reader activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleosome binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding ISO
Inferred from Sequence Orthology
more info
  
enables poly-ADP-D-ribose modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in site of DNA damage ISO
Inferred from Sequence Orthology
more info
  
is_active_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
chromodomain-helicase-DNA-binding protein 1-like
Names
amplified in liver cancer 1
NP_001405749.1
NP_080815.1
XP_017175190.1
XP_036019152.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418820.1 → NP_001405749.1  chromodomain-helicase-DNA-binding protein 1-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC140839

  2. NM_026539.3 → NP_080815.1  chromodomain-helicase-DNA-binding protein 1-like isoform 1

    See identical proteins and their annotated locations for NP_080815.1

    Status: VALIDATED

    Source sequence(s)
    AC140839
    Consensus CDS
    CCDS38561.1
    UniProtKB/Swiss-Prot
    Q3TMX1, Q6P5C0, Q9CXF7
    Related
    ENSMUSP00000029730.5, ENSMUST00000029730.5
    Conserved Domains (4) summary
    cd00046
    Location:59 → 199
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd03331
    Location:721 → 871
    Macro_Poa1p_like_SNF2; Macro domain, Poa1p_like family, SNF2 subfamily. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ...
    pfam00176
    Location:43 → 322
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:340 → 453
    Helicase_C; Helicase conserved C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    97468056..97517538 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163259.1 → XP_036019152.1  chromodomain-helicase-DNA-binding protein 1-like isoform X3

    Conserved Domains (1) summary
    PLN03142
    Location:39 → 549
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

  2. XM_017319701.3 → XP_017175190.1  chromodomain-helicase-DNA-binding protein 1-like isoform X2

    Conserved Domains (1) summary
    PLN03142
    Location:39 → 549
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CXF7.1 GenPept UniProtKB/Swiss-Prot:Q9CXF7

Gene LinkOut

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