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Wls wntless WNT ligand secretion mediator [ Mus musculus (house mouse) ]

Gene ID: 68151, updated on 9-Aug-2024

Summary

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Official Symbol
Wlsprovided by MGI
Official Full Name
wntless WNT ligand secretion mediatorprovided by MGI
Primary source
MGI:MGI:1915401
See related
Ensembl:ENSMUSG00000028173 AllianceGenome:MGI:1915401
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EVI; Gpr177; 5031439A09Rik
Summary
Enables Wnt-protein binding activity. Involved in several processes, including animal organ development; mesoderm formation; and positive regulation of canonical Wnt signaling pathway. Located in Golgi apparatus and cytoplasmic vesicle. Is expressed in several structures, including alimentary system; brain; genitourinary system; lung; and skin. Orthologous to human WLS (Wnt ligand secretion mediator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 41.9), limb E14.5 (RPKM 30.9) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Wls in Genome Data Viewer
Location:
3 H4; 3 82.65 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (159545287..159644302)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (159839650..159938666)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr3:159158158-159158459 Neighboring gene DEP domain containing 1a Neighboring gene retinal pigment epithelium 65 Neighboring gene STARR-seq mESC enhancer starr_09398 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:159503248-159503357 Neighboring gene succinate dehydrogenase complex, subunit B, iron sulfur (Ip) pseudogene Neighboring gene calponin 2 pseudogene Neighboring gene predicted gene, 23941

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Conditional deletion of Wntless in granulosa cells causes impaired corpora lutea formation and subfertility. Cheng J, et al. Aging (Albany NY), 2020 Dec 3. PMID 33291079, Free PMC Article
  2. Wntless regulates lipogenic gene expression in adipocytes and protects against diet-induced metabolic dysfunction. Bagchi DP, et al. Mol Metab, 2020 Sep. PMID 32325263, Free PMC Article
  3. Epithelial Wntless is dispensable for intestinal tumorigenesis in mouse models. Gao G, et al. Biochem Biophys Res Commun, 2019 Nov 19. PMID 31547988, Free PMC Article
  4. Selective deletion of WLS in peritubular myoid cells does not affect spermatogenesis or fertility in mice. Wang YQ, et al. Mol Reprod Dev, 2018 Jul. PMID 29693774
  5. Role of WNT signaling in epididymal sperm maturation. Cheng JM, et al. J Assist Reprod Genet, 2018 Feb. PMID 29152689, Free PMC Article

See all (153) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GPR177 in A-fiber sensory neurons drives diabetic neuropathic pain via WNT-mediated TRPV1 activation.
    Title: GPR177 in A-fiber sensory neurons drives diabetic neuropathic pain via WNT-mediated TRPV1 activation.
  2. Epithelial Wntless regulates postnatal alveologenesis.
    Title: Epithelial Wntless regulates postnatal alveologenesis.
  3. Yap Promotes Noncanonical Wnt Signals From Cardiomyocytes for Heart Regeneration.
    Title: Yap Promotes Noncanonical Wnt Signals From Cardiomyocytes for Heart Regeneration.
  4. The function of Wls in ovarian development.
    Title: The function of Wls in ovarian development.
  5. Wntless regulates lipogenic gene expression in adipocytes and protects against diet-induced metabolic dysfunction.
    Title: Wntless regulates lipogenic gene expression in adipocytes and protects against diet-induced metabolic dysfunction.
  6. Conditional deletion of Wntless in granulosa cells causes impaired corpora lutea formation and subfertility.
    Title: Conditional deletion of Wntless in granulosa cells causes impaired corpora lutea formation and subfertility.
  7. Data show that epithelial Wntless was required for the growth and differentiation of small intestinal organoids but not in live animals.
    Title: Epithelial Wntless is dispensable for intestinal tumorigenesis in mouse models.
  8. Deletion of WLS in peritubular myoid cells is not essential for male fertility in mice.
    Title: Selective deletion of WLS in peritubular myoid cells does not affect spermatogenesis or fertility in mice.
  9. Data show that Shh-Cre-mediated deletion of Wntless, the Wnt cargo protein, in mouse posterior limb mesenchyme causes bone syndactyly of the 3rd and 4th digits, resembling the human Malik-Percin type . Wntless(Shh-Cre) limbs displayed altered expression of hedgehog pathway genes and impaired noncanonical Wnt signaling activity.
    Title: Disruption of Wnt production in Shh lineage causes bone malformation in mice, mimicking human Malik-Percin-type syndactyly.
  10. WLS role in the principal cells of the caput epididymidis during sperm maturation
    Title: Role of WNT signaling in epididymal sperm maturation.
Submit: New GeneRIF Correction See all GeneRIFs (34)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Wnt-protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables Wnt-protein binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables mu-type opioid receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Wnt protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Wnt protein secretion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in Wnt protein secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in anterior/posterior axis specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cementum mineralization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in exocrine pancreas development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hindbrain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in mesoderm formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in midbrain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of Wnt protein secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of Wnt protein secretion ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite membrane ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in organelle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein wntless homolog
Names
G protein-coupled receptor 177
integral membrane protein GPR177
protein evenness interrupted homolog
wntless homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356349.1 → NP_001343278.1  protein wntless homolog isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC121906, AC225719, AK019886, BQ179316
    Conserved Domains (1) summary
    pfam06664
    Location:78 → 396
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

  2. NM_001356350.1 → NP_001343279.1  protein wntless homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC121906, AC175245, AC225719, AK044810
    Consensus CDS
    CCDS38684.1
    UniProtKB/Swiss-Prot
    Q6DID7, Q8CE42, Q9D2B7
    Related
    ENSMUSP00000143475.2, ENSMUST00000198878.2
    Conserved Domains (1) summary
    pfam06664
    Location:178 → 496
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

  3. NM_026582.5 → NP_080858.3  protein wntless homolog isoform 1

    See identical proteins and their annotated locations for NP_080858.3

    Status: VALIDATED

    Source sequence(s)
    AC121906, AC225719, BC075615
    Consensus CDS
    CCDS38684.1
    UniProtKB/Swiss-Prot
    Q6DID7, Q8CE42, Q9D2B7
    Related
    ENSMUSP00000067898.6, ENSMUST00000068952.10
    Conserved Domains (1) summary
    pfam06664
    Location:178 → 496
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    159545287..159644302
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DID7.1 GenPept UniProtKB/Swiss-Prot:Q6DID7

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