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SULT1C2 sulfotransferase family 1C member 2 [ Homo sapiens (human) ]

Gene ID: 6819, updated on 27-Nov-2024

Summary

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Official Symbol
SULT1C2provided by HGNC
Official Full Name
sulfotransferase family 1C member 2provided by HGNC
Primary source
HGNC:HGNC:11456
See related
Ensembl:ENSG00000198203 MIM:602385; AllianceGenome:HGNC:11456
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ST1C1; ST1C2; SULT1C1; humSULTC2
Summary
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in stomach (RPKM 61.8), kidney (RPKM 26.2) and 3 other tissues See more
Orthologs
all
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Genomic context

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See SULT1C2 in Genome Data Viewer
Location:
2q12.3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (108288895..108309915)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (108749770..108770814)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (108905351..108926371)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene sulfotransferase family 1C member 3 Neighboring gene WASF1 pseudogene 1 Neighboring gene sulfotransferase family, cytosolic, 1C, member 2 pseudogene 2 Neighboring gene sulfotransferase family 1C member 5, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16341

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The Sulfotransferase SULT1C2 Is Epigenetically Activated and Transcriptionally Induced by Tobacco Exposure and Is Associated with Patient Outcome in Lung Adenocarcinoma. Johnson C, et al. Int J Environ Res Public Health, 2021 Dec 31. PMID 35010676, Free PMC Article
  2. Homodimeric and heterodimeric aryl sulfotransferases catalyze the sulfuric acid esterification of N-hydroxy-2-acetylaminofluorene. Kiehlbauch CC, et al. J Biol Chem, 1995 Aug 11. PMID 7642552
  3. Human sulfotransferase SULT1C1: cDNA cloning, tissue-specific expression, and chromosomal localization. Her C, et al. Genomics, 1997 May 1. PMID 9169148
  4. Molecular characterization of ST1C1-related human sulfotransferase. Yoshinari K, et al. Carcinogenesis, 1998 May. PMID 9635888
  5. Sulfation of iodothyronines by human sulfotransferase 1C1 (SULT1C1)*. Li X, et al. Biochem Pharmacol, 2000 Dec 1. PMID 11077054

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Sulfotransferase SULT1C2 Is Epigenetically Activated and Transcriptionally Induced by Tobacco Exposure and Is Associated with Patient Outcome in Lung Adenocarcinoma.
    Title: The Sulfotransferase SULT1C2 Is Epigenetically Activated and Transcriptionally Induced by Tobacco Exposure and Is Associated with Patient Outcome in Lung Adenocarcinoma.
  2. Vitamin D receptor can interact directly with the SULT1C2 VDRE sequence to transcriptionally regulation SULT1C2 expression in colorectal tumor cells.
    Title: Transcriptional Regulation of Cytosolic Sulfotransferase 1C2 by Vitamin D Receptor in LS180 Human Colorectal Adenocarcinoma Cells.
  3. Our findings are the first to characterize the regulation of human SULT1C2 and SULT1C3 expression by several transcription factor activators.
    Title: Regulation of human cytosolic sulfotransferases 1C2 and 1C3 by nuclear signaling pathways in LS180 colorectal adenocarcinoma cells.
  4. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
    Title: MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: A Large-scale genetic association study of esophageal adenocarcinoma risk.
  6. Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Genomic polymorphisms provide prognostic information in intermediate-risk acute myeloblastic leukemia.
  7. gene resequencing and functional genomic studies
    Title: Human sulfotransferase SULT1C1 pharmacogenetics: gene resequencing and functional genomic studies.
  8. crystal structures of two members of SULT1 family, SULT1B1 and SULT1C1, both in complex with the product of the PAPS cofactor, adenosine-3-5-diphosphate (PAP).
    Title: Crystal structures of human sulfotransferases SULT1B1 and SULT1C1 complexed with the cofactor product adenosine-3'- 5'-diphosphate (PAP).
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables aryl sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aryl sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in amine metabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in sulfation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sulfation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sulfation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sulfotransferase 1C2
Names
SULT1C#1
sulfotransferase 1C1
sulfotransferase family, cytosolic, 1C, member 1
sulfotransferase family, cytosolic, 1C, member 2
NP_001047.1
NP_789795.1
XP_005264070.1
XP_054199546.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001056.4 → NP_001047.1  sulfotransferase 1C2 isoform a

    See identical proteins and their annotated locations for NP_001047.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the predominant transcript and it encodes isoform a.
    Source sequence(s)
    AA856596, AC019100, AF186252
    Consensus CDS
    CCDS2075.1
    UniProtKB/Swiss-Prot
    B2R813, O00338, Q53SG4
    UniProtKB/TrEMBL
    B4DLP0
    Related
    ENSP00000251481.6, ENST00000251481.11
    Conserved Domains (1) summary
    pfam00685
    Location:39 → 288
    Sulfotransfer_1; Sulfotransferase domain

  2. NM_176825.3 → NP_789795.1  sulfotransferase 1C2 isoform b

    See identical proteins and their annotated locations for NP_789795.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains one alternate in-frame segment and uses a different splice site in an adjacent exon when compared to variant 1. The resulting isoform (b) is longer with a different internal protein sequence when compared to isoform a.
    Source sequence(s)
    AA856596, AC019100, AF186255
    Consensus CDS
    CCDS2076.1
    UniProtKB/TrEMBL
    B4DLP0
    Related
    ENSP00000319622.5, ENST00000326853.9
    Conserved Domains (1) summary
    pfam00685
    Location:39 → 299
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    108288895..108309915
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264013.5 → XP_005264070.1  sulfotransferase 1C2 isoform X1

    UniProtKB/TrEMBL
    B4DLP0
    Conserved Domains (1) summary
    pfam00685
    Location:39 → 290
    Sulfotransfer_1; Sulfotransferase domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    108749770..108770814
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054343571.1 → XP_054199546.1  sulfotransferase 1C2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O00338.1 GenPept UniProtKB/Swiss-Prot:O00338

Gene LinkOut

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