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Krt71 keratin 71 [ Rattus norvegicus (Norway rat) ]

Gene ID: 683613, updated on 2-Nov-2024

Summary

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Official Symbol
Krt71provided by RGD
Official Full Name
keratin 71provided by RGD
Primary source
RGD:1584538
See related
EnsemblRapid:ENSRNOG00000049495 AllianceGenome:RGD:1584538
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be a structural constituent of skin epidermis. Predicted to be involved in hair follicle morphogenesis; intermediate filament organization; and keratinization. Predicted to be active in keratin filament. Used to study alopecia. Human ortholog(s) of this gene implicated in hypotrichosis 13. Orthologous to human KRT71 (keratin 71). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 47.9), Brain (RPKM 10.7) and 3 other tissues See more
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Genomic context

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See Krt71 in Genome Data Viewer
Location:
7q36
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (134752240..134778765, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (132873532..132898975, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (143345201..143371346, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene keratin 6A Neighboring gene keratin 5 Neighboring gene keratin 72 Neighboring gene keratin 73

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of the rat Rex mutation as a 7-bp deletion at splicing acceptor site of the Krt71 gene. Kuramoto T, et al. J Vet Med Sci, 2010 Jul. PMID 20179389
  2. A missense mutation within the helix initiation motif of the keratin K71 gene underlies autosomal dominant woolly hair/hypotrichosis. Fujimoto A, et al. J Invest Dermatol, 2012 Oct. PMID 22592156
  3. A small deletion hotspot in the type II keratin gene mK6irs1/Krt2-6g on mouse chromosome 15, a candidate for causing the wavy hair of the caracul (Ca) mutation. Kikkawa Y, et al. Genetics, 2003 Oct. PMID 14573483, Free PMC Article
  4. Mutations in the helix termination motif of mouse type I IRS keratin genes impair the assembly of keratin intermediate filament. Tanaka S, et al. Genomics, 2007 Dec. PMID 17920809
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a 7-bp deletion at the splicing acceptor site of intron 1 of the keratin 71 (Krt71) gene plays an important role in hair formation.
    Title: Identification of the rat Rex mutation as a 7-bp deletion at splicing acceptor site of the Krt71 gene.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables structural constituent of skin epidermis IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in hair follicle morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in intermediate filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intermediate filament organization ISO
Inferred from Sequence Orthology
more info
  
involved_in keratinization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in keratin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in keratin filament ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
keratin 71
Names
keratin 71, type II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276440.1 → NP_001263369.1  keratin 71

    See identical proteins and their annotated locations for NP_001263369.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A6KCR3, U3R784, U3R7A7, U5LJQ0
    Related
    ENSRNOP00000059953.3, ENSRNOT00000068533.5
    Conserved Domains (2) summary
    pfam00038
    Location:130 → 443
    Filament; Intermediate filament protein
    pfam16208
    Location:15 → 127
    Keratin_2_head; Keratin type II head

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    134752240..134778765 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079885.2 → XP_038935813.1  keratin 71 isoform X1

    UniProtKB/TrEMBL
    A6KCR3, U3R784, U3R7A7, U5LJQ0
    Conserved Domains (2) summary
    pfam00038
    Location:130 → 443
    Filament; Intermediate filament protein
    pfam16208
    Location:15 → 127
    Keratin_2_head; Keratin type II head
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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