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Nufip2 nuclear FMR1 interacting protein 2 [ Mus musculus (house mouse) ]

Gene ID: 68564, updated on 28-Oct-2024

Summary

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Official Symbol
Nufip2provided by MGI
Official Full Name
nuclear FMR1 interacting protein 2provided by MGI
Primary source
MGI:MGI:1915814
See related
Ensembl:ENSMUSG00000037857 AllianceGenome:MGI:1915814
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PIG1; mKIAA1321; 1110001M19Rik; 9530056D24Rik
Summary
Predicted to enable RNA binding activity. Predicted to be located in cytosol; nuclear body; and ribosome. Predicted to be active in cytoplasmic stress granule and nucleoplasm. Orthologous to human NUFIP2 (nuclear FMR1 interacting protein 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 5.5), bladder adult (RPKM 4.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Nufip2 in Genome Data Viewer
Location:
11 B5; 11 46.74 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (77576566..77608792)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (77685764..77717966)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S2 pseudogene Neighboring gene predicted gene, 23132 Neighboring gene STARR-seq mESC enhancer starr_30061 Neighboring gene STARR-seq mESC enhancer starr_30062 Neighboring gene STARR-positive B cell enhancer ABC_E10692 Neighboring gene STARR-seq mESC enhancer starr_30063 Neighboring gene crystallin, beta A1 Neighboring gene STARR-seq mESC enhancer starr_30065 Neighboring gene 60S ribosomal protein L15 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. 82-FIP, a novel FMRP (fragile X mental retardation protein) interacting protein, shows a cell cycle-dependent intracellular localization. Bardoni B, et al. Hum Mol Genet, 2003 Jul 15. PMID 12837692
  2. Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA. Rehage N, et al. Nat Commun, 2018 Jan 19. PMID 29352114, Free PMC Article
  3. Integrative genomics positions MKRN1 as a novel ribonucleoprotein within the embryonic stem cell gene regulatory network. Cassar PA, et al. EMBO Rep, 2015 Oct. PMID 26265008, Free PMC Article
  4. Vti1b promotes TRPV1 sensitization during inflammatory pain. Sondermann JR, et al. Pain, 2019 Feb. PMID 30335684
  5. RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity. Nitzsche A, et al. PLoS One, 2011 May 12. PMID 21589869, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA.
    Title: Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic stress granule IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in ribosome ISO
Inferred from Sequence Orthology
more info
  
located_in ribosome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
FMR1-interacting protein NUFIP2
Names
82 kDa FMRP-interacting protein
82-FIP
FMRP-interacting protein 2
proliferation-inducing gene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024205.2 → NP_001019376.1  FMR1-interacting protein NUFIP2

    See identical proteins and their annotated locations for NP_001019376.1

    Status: VALIDATED

    Source sequence(s)
    AL591136
    Consensus CDS
    CCDS25083.1
    UniProtKB/Swiss-Prot
    Q3TCE2, Q3V195, Q5F2E7, Q80TF1
    Related
    ENSMUSP00000098365.5, ENSMUST00000100802.11
    Conserved Domains (1) summary
    pfam15293
    Location:90 → 685
    NUFIP2; Nuclear fragile X mental retardation-interacting protein 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    77576566..77608792
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534062.5 → XP_006534125.1  FMR1-interacting protein NUFIP2 isoform X2

    See identical proteins and their annotated locations for XP_006534125.1

    UniProtKB/Swiss-Prot
    Q3TCE2, Q3V195, Q5F2E7, Q80TF1
    Conserved Domains (1) summary
    pfam15293
    Location:90 → 685
    NUFIP2; Nuclear fragile X mental retardation-interacting protein 2

  2. XM_036156930.1 → XP_036012823.1  FMR1-interacting protein NUFIP2 isoform X1

    Conserved Domains (1) summary
    pfam15293
    Location:108 → 700
    NUFIP2; Nuclear fragile X mental retardation-interacting protein 2

  3. XM_006534063.5 → XP_006534126.1  FMR1-interacting protein NUFIP2 isoform X3

    See identical proteins and their annotated locations for XP_006534126.1

    Conserved Domains (1) summary
    pfam15293
    Location:1 → 525
    NUFIP2; Nuclear fragile X mental retardation-interacting protein 2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5F2E7.1 GenPept UniProtKB/Swiss-Prot:Q5F2E7

Gene LinkOut

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