Fitm1 fat storage-inducing transmembrane protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fitm1provided by MGI
Official Full Name: fat storage-inducing transmembrane protein 1provided by MGI
Primary source: MGI:MGI:1915930
See related: Ensembl:ENSMUSG00000022215 AllianceGenome:MGI:1915930
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fit1; Cg10671; 1110028A07Rik
Summary: Enables diacylglycerol binding activity and triglyceride binding activity. Involved in lipid droplet formation and positive regulation of sequestering of triglyceride. Located in endoplasmic reticulum membrane. Is integral component of endoplasmic reticulum membrane. Is expressed in genitourinary system; gut; liver; lung; and musculature. Orthologous to human FITM1 (fat storage inducing transmembrane protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in heart adult (RPKM 115.2), kidney adult (RPKM 41.7) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C3; 14 28.19 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (55813131..55814409)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (55575674..55576952)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Findings indicate that lipid droplet (LD)produced by storage-inducing transmembrane proteins 2 (FIT2) were approximately 80% larger than storage-inducing transmembrane proteins 1 (FIT1).
Title: Direct binding of triglyceride to fat storage-inducing transmembrane proteins 1 and 2 is important for lipid droplet formation.
FIT1 and FIT2 are endoplasmic reticulum resident membrane proteins that induce lipid droplet accumulation in cell culture and when expressed in mouse liver.
Title: Evolutionarily conserved gene family important for fat storage.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:490602

Cg10671-pending (e-PCR), detects polymorphism
- UniSTS:256463

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables diacylglycerol binding	IDA Inferred from Direct Assay more info	PubMed
enables triglyceride binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in lipid droplet formation	IDA Inferred from Direct Assay more info	PubMed
involved_in lipid droplet organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid droplet organization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid storage	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of sequestering of triglyceride	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: fat storage-inducing transmembrane protein 1

Names: fat-inducing protein 1; fat-inducing transcript 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.