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Fpgs folylpolyglutamate synthase [ Rattus norvegicus (Norway rat) ]

Gene ID: 687266, updated on 10-Oct-2024

Summary

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Symbol
Fpgsprovided by RGD
Full Name
folylpolyglutamate synthaseprovided by RGD
Primary source
RGD:1587713
See related
EnsemblRapid:ENSRNOG00000050780 AllianceGenome:RGD:1587713
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables tetrahydrofolylpolyglutamate synthase activity. Involved in animal organ regeneration; brain development; and liver development. Predicted to be active in cytosol and mitochondrion. Orthologous to human FPGS (folylpolyglutamate synthase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 144.6), Kidney (RPKM 75.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fpgs in Genome Data Viewer
Location:
3p11
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (36370505..36391314, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (15972800..15993592, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (11717667..11729694, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene adenylate kinase 1 Neighboring gene endoglin Neighboring gene cyclin-dependent kinase 9 Neighboring gene SH2 domain containing 3C Neighboring gene RNA, U6 small nuclear 899

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Glutamyl hydrolase. pharmacological role and enzymatic characterization. Galivan J, et al. Pharmacol Ther, 2000 Mar. PMID 10739875
  2. Enzymatic synthesis of folylpolyglutamates. Characterization of the reaction and its products. McGuire JJ, et al. J Biol Chem, 1980 Jun 25. PMID 6892914
  3. In vitro methotrexate polyglutamate synthesis by rat liver folylpolyglutamate synthetase and inhibition by bromosulfophthalein. McGuire JJ, et al. Adv Exp Med Biol, 1983. PMID 6193685
  4. Folylpolyglutamate synthetase activity in regenerating rat liver. Tolomelli B, et al. Int J Vitam Nutr Res, 1987. PMID 3654111
  5. Activation of mammalian folylpolyglutamate synthetase by sodium bicarbonate. Bolanowska WE, et al. Arch Biochem Biophys, 1990 Sep. PMID 2168155

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables tetrahydrofolylpolyglutamate synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tetrahydrofolylpolyglutamate synthase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in animal organ regeneration IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in folic acid-containing compound metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glutamate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in liver development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in nucleoside metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in one-carbon metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tetrahydrofolylpolyglutamate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tetrahydrofolylpolyglutamate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
folylpolyglutamate synthase, mitochondrial
NP_001139597.2
XP_038961794.1
XP_063140632.1
XP_063140633.1
XP_063140634.1
XP_063140635.1
XP_063140636.1
XP_063140637.1
XP_063140638.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146125.2 → NP_001139597.2  folylpolyglutamate synthase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001139597.2

    Status: PROVISIONAL

    Source sequence(s)
    CH474001
    UniProtKB/TrEMBL
    A6JU77, M0R401
    Related
    ENSRNOP00000064076.4, ENSRNOT00000070916.4
    Conserved Domains (1) summary
    PLN02881
    Location:42 → 581
    PLN02881; tetrahydrofolylpolyglutamate synthase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    36370505..36391314 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063284563.1 → XP_063140633.1  folylpolyglutamate synthase, mitochondrial isoform X3

  2. XM_063284566.1 → XP_063140636.1  folylpolyglutamate synthase, mitochondrial isoform X6

    UniProtKB/TrEMBL
    A0A8I6AA44
    Related
    ENSRNOP00000088525.1, ENSRNOT00000106975.2

  3. XM_063284564.1 → XP_063140634.1  folylpolyglutamate synthase, mitochondrial isoform X4

  4. XM_063284567.1 → XP_063140637.1  folylpolyglutamate synthase, mitochondrial isoform X7

    Related
    ENSRNOP00000108396.1, ENSRNOT00000154787.1

  5. XM_063284562.1 → XP_063140632.1  folylpolyglutamate synthase, mitochondrial isoform X1

  6. XM_039105866.2 → XP_038961794.1  folylpolyglutamate synthase, mitochondrial isoform X2

    Related
    ENSRNOP00000108804.1, ENSRNOT00000139275.1
    Conserved Domains (1) summary
    PLN02881
    Location:42 → 670
    PLN02881; tetrahydrofolylpolyglutamate synthase

  7. XM_063284565.1 → XP_063140635.1  folylpolyglutamate synthase, mitochondrial isoform X5

  8. XM_063284568.1 → XP_063140638.1  folylpolyglutamate synthase, mitochondrial isoform X8

Nucleotide Protein Strain
Heading Accession and Version

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