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Trp53inp2 transformation related protein 53 inducible nuclear protein 2 [ Mus musculus (house mouse) ]

Gene ID: 68728, updated on 9-Dec-2024

Summary

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Official Symbol
Trp53inp2provided by MGI
Official Full Name
transformation related protein 53 inducible nuclear protein 2provided by MGI
Primary source
MGI:MGI:1915978
See related
Ensembl:ENSMUSG00000038375 AllianceGenome:MGI:1915978
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tp53inp2; 1110029F20Rik
Summary
Enables ubiquitin binding activity. Acts upstream of or within several processes, including macroautophagy; osteoblast differentiation; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be active in autophagosome and nucleus. Is expressed in several structures, including 1st branchial arch; facial prominence; limb mesenchyme; nervous system; and otocyst. Orthologous to human TP53INP2 (tumor protein p53 inducible nuclear protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 127.9), heart adult (RPKM 122.6) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Trp53inp2 in Genome Data Viewer
Location:
2 H1; 2 77.26 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (155223742..155231767)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (155381811..155389847)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene microtubule-associated protein 1 light chain 3 alpha Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class U Neighboring gene STARR-positive B cell enhancer ABC_E6004 Neighboring gene microRNA 695 Neighboring gene STARR-positive B cell enhancer ABC_E11173 Neighboring gene STARR-positive B cell enhancer ABC_E4511 Neighboring gene nuclear receptor coactivator 6 Neighboring gene ribosomal protein L8 pseudogene Neighboring gene carnitine deficiency-associated gene expressed in ventricle 3 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TP53INP2 knockdown inhibits inflammatory response and apoptosis after spinal cord injury. Sun P, et al. Immun Inflamm Dis, 2024 Apr. PMID 38652010, Free PMC Article
  2. TP53INP2-dependent activation of muscle autophagy ameliorates sarcopenia and promotes healthy aging. Sebastián D, et al. Autophagy, 2024 Aug. PMID 38545813, Free PMC Article
  3. Metabolic status differentiates Trp53inp2 function in pressure-overload induced heart failure. Liu J, et al. Front Cardiovasc Med, 2023. PMID 38188257, Free PMC Article
  4. Role of diabetes- and obesity-related protein in the regulation of osteoblast differentiation. Linares GR, et al. Am J Physiol Endocrinol Metab, 2011 Jul. PMID 21467300, Free PMC Article
  5. The coding region of TP53INP2, a gene expressed in the developing nervous system, is not altered in a family with autosomal recessive non-progressive infantile ataxia on chromosome 20q11-q13. Bennetts JS, et al. Dev Dyn, 2007 Mar. PMID 17238154

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TP53INP2-dependent activation of muscle autophagy ameliorates sarcopenia and promotes healthy aging.
    Title: TP53INP2-dependent activation of muscle autophagy ameliorates sarcopenia and promotes healthy aging.
  2. TP53INP2 knockdown inhibits inflammatory response and apoptosis after spinal cord injury.
    Title: TP53INP2 knockdown inhibits inflammatory response and apoptosis after spinal cord injury.
  3. Tp53inp2 is an atypical mRNA that regulates axon growth by enhancing NGF-TrkA signaling in a translation-independent manner.
    Title: Regulation of NGF Signaling by an Axonal Untranslated mRNA.
  4. TP53INP2 modulates adipogenesis through autophagy-dependent sequestration of GSK3beta into late endosomes and beta catenin activation, regulating adiposity.
    Title: TP53INP2 regulates adiposity by activating β-catenin through autophagy-dependent sequestration of GSK3β.
  5. TP53INP2 repression is part of an adaptive mechanism aimed at preserving muscle mass under conditions in which insulin action is deficient.
    Title: Autophagy-regulating TP53INP2 mediates muscle wasting and is repressed in diabetes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ubiquitin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of protein localization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of protein localization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within tissue homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in PML body IEA
Inferred from Electronic Annotation
more info
  
is_active_in autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in autophagosome ISO
Inferred from Sequence Orthology
more info
  
located_in autophagosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
tumor protein p53-inducible nuclear protein 2
Names
diabetes and obesity-regulated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418655.1 → NP_001405584.1  tumor protein p53-inducible nuclear protein 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL845325
    UniProtKB/Swiss-Prot
    Q3TDL6, Q711P5, Q8CFU8, Q8CHM4

  2. NM_001418656.1 → NP_001405585.1  tumor protein p53-inducible nuclear protein 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL845325
    UniProtKB/Swiss-Prot
    Q3TDL6, Q711P5, Q8CFU8, Q8CHM4

  3. NM_001418657.1 → NP_001405586.1  tumor protein p53-inducible nuclear protein 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL845325
    UniProtKB/Swiss-Prot
    Q3TDL6, Q711P5, Q8CFU8, Q8CHM4

  4. NM_001418658.1 → NP_001405587.1  tumor protein p53-inducible nuclear protein 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL845325
    UniProtKB/TrEMBL
    G3UXZ2
    Related
    ENSMUSP00000133880.2, ENSMUST00000174685.8

  5. NM_001418659.1 → NP_001405588.1  tumor protein p53-inducible nuclear protein 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL845325
    UniProtKB/TrEMBL
    G3UXZ2

  6. NM_001418660.1 → NP_001405589.1  tumor protein p53-inducible nuclear protein 2 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL845325

  7. NM_001418661.1 → NP_001405590.1  tumor protein p53-inducible nuclear protein 2 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL845325

  8. NM_178111.4 → NP_835212.1  tumor protein p53-inducible nuclear protein 2 isoform a

    See identical proteins and their annotated locations for NP_835212.1

    Status: VALIDATED

    Source sequence(s)
    AL845325
    Consensus CDS
    CCDS16947.1
    UniProtKB/Swiss-Prot
    Q3TDL6, Q711P5, Q8CFU8, Q8CHM4
    Related
    ENSMUSP00000037627.8, ENSMUST00000043237.14
    Conserved Domains (1) summary
    pfam14839
    Location:28 → 212
    DOR; DOR family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    155223742..155231767
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252040.2 → XP_030107900.1  tumor protein p53-inducible nuclear protein 2 isoform X3

    Conserved Domains (1) summary
    pfam14839
    Location:72 → 217
    DOR; DOR family

  2. XM_017319242.2 → XP_017174731.1  tumor protein p53-inducible nuclear protein 2 isoform X3

    Conserved Domains (1) summary
    pfam14839
    Location:72 → 217
    DOR; DOR family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CFU8.4 GenPept UniProtKB/Swiss-Prot:Q8CFU8

Gene LinkOut

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