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Cgrrf1 cell growth regulator with ring finger domain 1 [ Mus musculus (house mouse) ]

Gene ID: 68755, updated on 9-Dec-2024

Summary

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Official Symbol
Cgrrf1provided by MGI
Official Full Name
cell growth regulator with ring finger domain 1provided by MGI
Primary source
MGI:MGI:1916368
See related
Ensembl:ENSMUSG00000055128 AllianceGenome:MGI:1916368
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CGR19; 1110038G02Rik; 1810009H17Rik
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in negative regulation of cell growth. Predicted to be located in endoplasmic reticulum and nucleoplasm. Is expressed in several structures, including central nervous system; genitourinary system; and retina. Orthologous to human CGRRF1 (cell growth regulator with ring finger domain 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in testis adult (RPKM 22.6), bladder adult (RPKM 15.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Cgrrf1 in Genome Data Viewer
Location:
14 C1; 14 24.34 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (47069591..47091655)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (46832134..46854198)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene cornichon family AMPA receptor auxiliary protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E7306 Neighboring gene STARR-positive B cell enhancer ABC_E5430 Neighboring gene glia maturation factor, beta Neighboring gene predicted gene, 34934 Neighboring gene sterile alpha motif domain containing 4 Neighboring gene STARR-seq mESC enhancer starr_36564 Neighboring gene predicted gene, 52120 Neighboring gene microRNA 378c

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Overexpression of Long Non-coding RNA 4933425B07Rik Causes Urinary Malformations in Mice. Tan L, et al. Front Cell Dev Biol, 2021. PMID 33681192, Free PMC Article
  2. Discovery of novel protein partners of the transcription factor FOXL2 provides insights into its physiopathological roles. L'Hôte D, et al. Hum Mol Genet, 2012 Jul 15. PMID 22544055
  3. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019
  4. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  5. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in negative regulation of cell growth IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cell growth regulator with RING finger domain protein 1
Names
cell growth regulatory gene 19 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360454.1 → NP_001347383.1  cell growth regulator with RING finger domain protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC131586, AK030755, BY098099, BY237281, CJ157211
    Conserved Domains (2) summary
    COG5574
    Location:224 → 318
    PEX10; RING-finger-containing E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
    cd16787
    Location:272 → 308
    mRING-HC-C3HC5_CGRF1; Modified RING finger, HC subclass (C3HC5-type), found in cell growth regulator with RING finger domain protein 1 (CGRRF1) and similar proteins

  2. NM_001360455.1 → NP_001347384.1  cell growth regulator with RING finger domain protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK004156, AK030755, BY237281, BY704400, CJ157211
    Consensus CDS
    CCDS88640.1
    UniProtKB/TrEMBL
    A0A2I3BR24
    Related
    ENSMUSP00000154423.2, ENSMUST00000140114.3

  3. NM_026832.4 → NP_081108.2  cell growth regulator with RING finger domain protein 1 isoform 1

    See identical proteins and their annotated locations for NP_081108.2

    Status: VALIDATED

    Source sequence(s)
    AC131586, AK030755, BY237281, CJ157211
    Consensus CDS
    CCDS26981.1
    UniProtKB/Swiss-Prot
    Q3U3F1, Q8BMJ7, Q8CI24
    Related
    ENSMUSP00000070548.9, ENSMUST00000068532.10
    Conserved Domains (1) summary
    pfam13920
    Location:270 → 315
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    47069591..47091655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BMJ7.1 GenPept UniProtKB/Swiss-Prot:Q8BMJ7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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