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Denr density regulated reinitiation and release factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 687565, updated on 4-Jan-2025

Summary

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Official Symbol
Denrprovided by RGD
Official Full Name
density regulated reinitiation and release factorprovided by RGD
Primary source
RGD:1584200
See related
EnsemblRapid:ENSRNOG00000001106 AllianceGenome:RGD:1584200
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable translation initiation factor activity. Predicted to be involved in IRES-dependent viral translational initiation; cytoplasmic translational initiation; and ribosome disassembly. Predicted to be active in cytoplasm. Orthologous to human DENR (density regulated re-initiation and release factor). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 118.9), Brain (RPKM 115.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Denr in Genome Data Viewer
Location:
12q15
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (38323433..38346207, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (32662512..32685283, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (38095717..38117758, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene huntingtin interacting protein 1 related Neighboring gene coiled-coil domain containing 62 Neighboring gene hydroxycarboxylic acid receptor 1 Neighboring gene hydroxycarboxylic acid receptor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Activities of Ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling. Skabkin MA, et al. Genes Dev, 2010 Aug 15. PMID 20713520, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in IRES-dependent viral translational initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in formation of translation preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in formation of translation preinitiation complex ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosome disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in translation reinitiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
density-regulated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001115046.2 → NP_001108518.1  density-regulated protein

    Status: PROVISIONAL

    Source sequence(s)
    BC158753
    UniProtKB/TrEMBL
    B0BNB2, D3ZU54
    Related
    ENSRNOP00000001467.9, ENSRNOT00000001467.9
    Conserved Domains (1) summary
    TIGR01159
    Location:24 → 189
    DRP1; density-regulated protein DRP1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    38323433..38346207 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089758.2 → XP_038945686.1  density-regulated protein isoform X1

    UniProtKB/TrEMBL
    B0BNB2, D3ZU54
    Conserved Domains (1) summary
    TIGR01159
    Location:24 → 189
    DRP1; density-regulated protein DRP1

  2. XM_039089759.2 → XP_038945687.1  density-regulated protein isoform X2

    Conserved Domains (1) summary
    cl00229
    Location:24 → 134
    eIF1_SUI1_like; Eukaryotic initiation factor 1 and related proteins
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.