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Ak8 adenylate kinase 8 [ Mus musculus (house mouse) ]

Gene ID: 68870, updated on 28-Oct-2024

Summary

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Official Symbol
Ak8provided by MGI
Official Full Name
adenylate kinase 8provided by MGI
Primary source
MGI:MGI:1916120
See related
Ensembl:ENSMUSG00000026807 AllianceGenome:MGI:1916120
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AK 8; 1190002A17Rik
Summary
Predicted to enable (d)CMP kinase activity; adenylate kinase activity; and nucleoside diphosphate kinase activity. Acts upstream of or within ventricular system development. Located in axoneme and sperm flagellum. Used to study hydrocephalus. Orthologous to human AK8 (adenylate kinase 8). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Restricted expression toward testis adult (RPKM 80.2) See more
Orthologs
human all
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Genomic context

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See Ak8 in Genome Data Viewer
Location:
2 A3; 2 19.38 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (28588287..28703177)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (28698275..28813165)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2606 Neighboring gene STARR-positive B cell enhancer ABC_E3365 Neighboring gene STARR-positive B cell enhancer ABC_E2033 Neighboring gene predicted gene, 52548 Neighboring gene growth factor independent 1B Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:28496521-28496713 Neighboring gene TSC complex subunit 1 Neighboring gene sperm acrosome associated 9 Neighboring gene microRNA 3088 Neighboring gene STARR-seq mESC enhancer starr_04033 Neighboring gene high mobility group box 3 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10088 Neighboring gene general transcription factor IIIC, polypeptide 4 Neighboring gene DEAD/H box helicase 31 Neighboring gene BarH like homeobox 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Adenine nucleotide metabolism and a role for AMP in modulating flagellar waveforms in mouse sperm. Vadnais ML, et al. Biol Reprod, 2014 Jun. PMID 24740601, Free PMC Article
  2. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. Kisseleva T, et al. Proc Natl Acad Sci U S A, 2012 Jun 12. PMID 22566629, Free PMC Article
  3. CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module. Dougherty GW, et al. Nat Commun, 2020 Nov 2. PMID 33139725, Free PMC Article
  4. Congenital hydrocephalus in genetically engineered mice. Vogel P, et al. Vet Pathol, 2012 Jan. PMID 21746835
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC118311, MGC130365

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables (d)CMP kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables (d)CMP kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables AMP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables adenylate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenylate kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables adenylate kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables nucleoside diphosphate kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleoside diphosphate kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in nucleoside monophosphate phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ventricular system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axoneme IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
adenylate kinase 8
Names
ATP-AMP transphosphorylase 8
Adenylate kinase isoenzyme 4, mitochondrial (ATP-AMP transphosphorylase)
putative adenylate kinase-like protein C9orf98 homolog
NP_001029046.2
XP_006498350.1
XP_006498351.1
XP_006498352.1
XP_006498354.1
XP_017174733.1
XP_017174734.1
XP_030107901.1
XP_030107902.1
XP_036018423.1
XP_036018424.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033874.2 → NP_001029046.2  adenylate kinase 8

    See identical proteins and their annotated locations for NP_001029046.2

    Status: VALIDATED

    Source sequence(s)
    AB046266, BC109352, BY100469
    Consensus CDS
    CCDS15846.1
    UniProtKB/Swiss-Prot
    Q32M07, Q497L2
    Related
    ENSMUSP00000073789.7, ENSMUST00000074156.7
    Conserved Domains (2) summary
    cd01428
    Location:270 → 462
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    TIGR01351
    Location:270 → 468
    adk; adenylate kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    28588287..28703177
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498287.4 → XP_006498350.1  adenylate kinase 8 isoform X1

    See identical proteins and their annotated locations for XP_006498350.1

    Conserved Domains (1) summary
    cd01428
    Location:299 → 491
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

  2. XM_006498288.5 → XP_006498351.1  adenylate kinase 8 isoform X1

    See identical proteins and their annotated locations for XP_006498351.1

    Conserved Domains (1) summary
    cd01428
    Location:299 → 491
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

  3. XM_036162530.1 → XP_036018423.1  adenylate kinase 8 isoform X6

    Conserved Domains (1) summary
    cd01428
    Location:241 → 433
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

  4. XM_036162531.1 → XP_036018424.1  adenylate kinase 8 isoform X7

    Conserved Domains (1) summary
    cd01428
    Location:240 → 432
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

  5. XM_006498291.4 → XP_006498354.1  adenylate kinase 8 isoform X4

    Conserved Domains (1) summary
    cd01428
    Location:270 → 462
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

  6. XM_030252041.2 → XP_030107901.1  adenylate kinase 8 isoform X1

    Conserved Domains (1) summary
    cd01428
    Location:299 → 491
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

  7. XM_006498289.2 → XP_006498352.1  adenylate kinase 8 isoform X2

    Conserved Domains (1) summary
    cd01428
    Location:298 → 490
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

  8. XM_017319245.2 → XP_017174734.1  adenylate kinase 8 isoform X8

    Conserved Domains (2) summary
    cd01428
    Location:88 → 278
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    cl17190
    Location:299 → 352
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  9. XM_030252042.1 → XP_030107902.1  adenylate kinase 8 isoform X5

    Conserved Domains (1) summary
    cd01428
    Location:269 → 461
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

  10. XM_017319244.3 → XP_017174733.1  adenylate kinase 8 isoform X3

    Conserved Domains (1) summary
    cd01428
    Location:272 → 464
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q32M07.1 GenPept UniProtKB/Swiss-Prot:Q32M07

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