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Atp23 ATP23 metallopeptidase and ATP synthase assembly factor homolog [ Mus musculus (house mouse) ]

Gene ID: 68876, updated on 9-Dec-2024

Summary

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Official Symbol
Atp23provided by MGI
Official Full Name
ATP23 metallopeptidase and ATP synthase assembly factor homologprovided by MGI
Primary source
MGI:MGI:1916984
See related
Ensembl:ENSMUSG00000025436 AllianceGenome:MGI:1916984
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Xrcc6bp1; 1110068E08Rik; 2410012H02Rik
Summary
Predicted to enable metal ion binding activity and metalloendopeptidase activity. Predicted to be involved in mitochondrial protein processing and mitochondrial proton-transporting ATP synthase complex assembly. Predicted to be located in several cellular components, including cell junction; cytosol; and plasma membrane. Is expressed in cerebral cortex subventricular zone; cerebral cortex ventricular layer; and cortical plate. Orthologous to human ATP23 (ATP23 metallopeptidase and ATP synthase assembly factor homolog). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 1.5), limb E14.5 (RPKM 1.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Atp23 in Genome Data Viewer
Location:
10 D3; 10 73.84 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (126703698..126737893, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (126867829..126902024, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_28191 Neighboring gene predicted gene, 24179 Neighboring gene STARR-seq mESC enhancer starr_28192 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1409 Neighboring gene STARR-seq mESC enhancer starr_28193 Neighboring gene predicted gene, 30456 Neighboring gene predicted gene, 30539

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Kub3 Deficiency Causes Aberrant Late Embryonic Lung Development in Mice by the FGF Signaling Pathway. Yang G, et al. Int J Mol Sci, 2022 May 27. PMID 35682694, Free PMC Article
  2. Gene expression in the developing mouse retina by EST sequencing and microarray analysis. Mu X, et al. Nucleic Acids Res, 2001 Dec 15. PMID 11812828, Free PMC Article
  3. Short-lived AUF1 p42-binding mRNAs of RANKL and BCL6 have two distinct instability elements each. Dogar AM, et al. PLoS One, 2018. PMID 30418981, Free PMC Article
  4. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in mitochondrial protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial proton-transporting ATP synthase complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondrial inner membrane protease ATP23 homolog
Names
XRCC6 binding protein 1
NP_001153031.1
NP_001345898.1
NP_001345899.1
NP_081134.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159559.1 → NP_001153031.1  mitochondrial inner membrane protease ATP23 homolog isoform 1

    See identical proteins and their annotated locations for NP_001153031.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate splice site in its 3' terminal exon compared to variant 4. The encoded isoform (1) has a shorter and distinct C-terminus compared to isoform 4.
    Source sequence(s)
    AK004405, BG801921, CB203044
    Consensus CDS
    CCDS48710.1
    UniProtKB/TrEMBL
    G3UW46
    Related
    ENSMUSP00000128382.2, ENSMUST00000168520.3
    Conserved Domains (1) summary
    pfam09768
    Location:50 → 220
    Peptidase_M76; Peptidase M76 family

  2. NM_001358969.1 → NP_001345898.1  mitochondrial inner membrane protease ATP23 homolog isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in its 3' terminal exon, resulting in a frameshift compared to variant 4. The encoded isoform (3) has a shorter and distinct C-terminus compared to isoform 4.
    Source sequence(s)
    AA221211, AC122018, BE863276, BY704635, CB203044
    Conserved Domains (1) summary
    pfam09768
    Location:50 → 179
    Peptidase_M76; Peptidase M76 family

  3. NM_001358970.1 → NP_001345899.1  mitochondrial inner membrane protease ATP23 homolog isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform.
    Source sequence(s)
    AA221211, AC122018, AK039002, BE863276, BY704635, CB203044
    Related
    ENSMUST00000220051.2
    Conserved Domains (1) summary
    pfam09768
    Location:50 → 179
    Peptidase_M76; Peptidase M76 family

  4. NM_026858.3 → NP_081134.2  mitochondrial inner membrane protease ATP23 homolog isoform 2

    See identical proteins and their annotated locations for NP_081134.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 3' exon compared to variant 4. The encoded isoform (2)is shorter and has a distinct C-terminus compared to isoform 4.
    Source sequence(s)
    BC030630, BG801921
    Consensus CDS
    CCDS24220.1
    UniProtKB/Swiss-Prot
    Q9CWQ3
    Related
    ENSMUSP00000026504.6, ENSMUST00000026504.13
    Conserved Domains (1) summary
    pfam09768
    Location:50 → 192
    Peptidase_M76; Peptidase M76 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    126703698..126737893 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003948791.2 RNA Sequence

  2. XR_003948790.1 RNA Sequence

  3. XR_004936268.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CWQ3.1 GenPept UniProtKB/Swiss-Prot:Q9CWQ3

Gene LinkOut

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