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Pygo2 pygopus 2 [ Mus musculus (house mouse) ]

Gene ID: 68911, updated on 17-Aug-2024

Summary

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Official Symbol
Pygo2provided by MGI
Official Full Name
pygopus 2provided by MGI
Primary source
MGI:MGI:1916161
See related
Ensembl:ENSMUSG00000047824 AllianceGenome:MGI:1916161
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1190004M21Rik
Summary
Enables chromatin binding activity; histone acetyltransferase regulator activity; and histone binding activity. Involved in canonical Wnt signaling pathway. Acts upstream of or within several processes, including animal organ development; positive regulation of chromatin binding activity; and spermatid nucleus differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and skin. Orthologous to human PYGO2 (pygopus family PHD finger 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 22.5), ovary adult (RPKM 22.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Pygo2 in Genome Data Viewer
Location:
3 F1; 3 39.12 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89337521..89342438)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89430114..89435131)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08239 Neighboring gene CDC28 protein kinase 1b Neighboring gene src homology 2 domain-containing transforming protein C1 Neighboring gene STARR-positive B cell enhancer ABC_E2080 Neighboring gene STARR-positive B cell enhancer ABC_E9557 Neighboring gene pre B cell leukemia transcription factor interacting protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E6071 Neighboring gene STARR-positive B cell enhancer ABC_E2081 Neighboring gene phosphomevalonate kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A Pygopus 2-Histone Interaction Is Critical for Cancer Cell Dedifferentiation and Progression in Malignant Breast Cancer. Saxena M, et al. Cancer Res, 2020 Sep 1. PMID 32586983
  2. Neural crest stem cell-specific deletion of the Pygopus2 gene modulates hair follicle development. Narytnyk A, et al. Stem Cell Rev Rep, 2014 Feb. PMID 23955574, Free PMC Article
  3. Chromatin effector Pygo2 mediates Wnt-notch crosstalk to suppress luminal/alveolar potential of mammary stem and basal cells. Gu B, et al. Cell Stem Cell, 2013 Jul 3. PMID 23684539, Free PMC Article
  4. Developmental phenotypes and reduced Wnt signaling in mice deficient for pygopus 2. Li B, et al. Genesis, 2007 May. PMID 17458864
  5. Pygopus2 ameliorates mesenteric adipocyte poor differentiation to alleviate Crohn's disease -like colitis via the Axin2/GSK3β pathway. Li J, et al. Cell Prolif, 2022 Oct. PMID 35707871, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pygopus2 ameliorates mesenteric adipocyte poor differentiation to alleviate Crohn's disease -like colitis via the Axin2/GSK3beta pathway.
    Title: Pygopus2 ameliorates mesenteric adipocyte poor differentiation to alleviate Crohn's disease -like colitis via the Axin2/GSK3β pathway.
  2. A Pygopus 2-Histone Interaction Is Critical for Cancer Cell Dedifferentiation and Progression in Malignant Breast Cancer.
    Title: A Pygopus 2-Histone Interaction Is Critical for Cancer Cell Dedifferentiation and Progression in Malignant Breast Cancer.
  3. Our study revealed an association between Pygo2 function and obesity or diabetes. we showed that Pygo2 exhibited a declined expression pattern during adipocyte differentiation, resulting in an attenuated Wnt/beta-catenin output level. We further showed impaired glucose tolerance and decreased systemic insulin sensitivity in Pygo2-deficient mice.
    Title: Pygo2 Regulates Adiposity and Glucose Homeostasis via β-Catenin-Axin2-GSK3β Signaling Pathway.
  4. Suggest that Pygo2 has a tumor promoting function related to Wnt/ss-catenin signaling activity during intestinal tumor initiation and progression.
    Title: The role of Pygo2 for Wnt/ß-catenin signaling activity during intestinal tumor initiation and progression.
  5. Transcriptional cofactors Bcl9, Bcl9l and Pygo1/2 act independently of beta-catenin to ensure proper enamel formation.
    Title: A cytoplasmic role of Wnt/β-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation.
  6. It analyzed Wnt1-cre(+/-)::Pygo2(-/-) mice in which the beta-catenin co-activator gene, Pygopus 2 (Pygo2), is deleted specifically in neural crest cells.
    Title: Neural crest stem cell-specific deletion of the Pygopus2 gene modulates hair follicle development.
  7. These findings identify Pygo2 as an important regulator of Wnt/beta-catenin function in skin epithelia and p53 activation as a prominent downstream event of beta-catenin/Pygo2 action in stem cell activation.
    Title: Pygo2 regulates β-catenin-induced activation of hair follicle stem/progenitor cells and skin hyperplasia.
  8. these results suggest that Pygo2 acts at a step downstream of mammary stem cell accumulation to facilitate transformation, and that it regulates the tumor initiating capacity and lineage preference of the already transformed mammary cells, in MMTV-Wnt1 mice.
    Title: Chromatin effector Pygo2 regulates mammary tumor initiation and heterogeneity in MMTV-Wnt1 mice.
  9. even in the absence of the potentially redundant Pygo1, Pygo2 does not require the H3K4me2/3 binding activity to sustain its function during mouse development
    Title: The Pygo2-H3K4me2/3 interaction is dispensable for mouse development and Wnt signaling-dependent transcription.
  10. Pygo2 converges with Wnt/beta-catenin signaling on progenitor cell regulation and cell cycle gene expression.
    Title: Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone acetyltransferase regulator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within anatomical structure development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within anatomical structure development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within brain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within developmental growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in kidney development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within kidney development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within lens development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mammary gland development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of chromatin binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of mammary gland epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within roof of mouth development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatid development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in spermatid nucleus differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spermatid nucleus differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of beta-catenin-TCF complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
pygopus homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293763.2 → NP_001280692.1  pygopus homolog 2 isoform b

    See identical proteins and their annotated locations for NP_001280692.1

    Status: VALIDATED

    Source sequence(s)
    AC171273
    Consensus CDS
    CCDS38494.1
    UniProtKB/TrEMBL
    Q3V113
    Conserved Domains (2) summary
    PRK14959
    Location:135 → 271
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    cd15636
    Location:291 → 344
    PHD_PYGO2; PHD finger found in pygopus homolog 2 (PYGO2)

  2. NM_001293766.3 → NP_001280695.1  pygopus homolog 2 isoform b

    See identical proteins and their annotated locations for NP_001280695.1

    Status: VALIDATED

    Source sequence(s)
    AC171273
    Consensus CDS
    CCDS38494.1
    UniProtKB/TrEMBL
    Q3V113
    Conserved Domains (2) summary
    PRK14959
    Location:135 → 271
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    cd15636
    Location:291 → 344
    PHD_PYGO2; PHD finger found in pygopus homolog 2 (PYGO2)

  3. NM_001293767.2 → NP_001280696.1  pygopus homolog 2 isoform b

    See identical proteins and their annotated locations for NP_001280696.1

    Status: VALIDATED

    Source sequence(s)
    AC171273
    Consensus CDS
    CCDS38494.1
    UniProtKB/TrEMBL
    Q3V113
    Conserved Domains (2) summary
    PRK14959
    Location:135 → 271
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    cd15636
    Location:291 → 344
    PHD_PYGO2; PHD finger found in pygopus homolog 2 (PYGO2)

  4. NM_001293768.2 → NP_001280697.1  pygopus homolog 2 isoform a

    See identical proteins and their annotated locations for NP_001280697.1

    Status: VALIDATED

    Source sequence(s)
    AC171273
    Consensus CDS
    CCDS79952.1
    UniProtKB/TrEMBL
    Q80V76
    Related
    ENSMUSP00000053672.5, ENSMUST00000060061.11
    Conserved Domains (1) summary
    cd15636
    Location:328 → 381
    PHD_PYGO2; PHD finger found in pygopus homolog 2 (PYGO2)

  5. NM_001429109.1 → NP_001416038.1  pygopus homolog 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC171273
    UniProtKB/TrEMBL
    Q3V113

  6. NM_001429110.1 → NP_001416039.1  pygopus homolog 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC171273
    UniProtKB/TrEMBL
    Q3V113

  7. NM_026869.3 → NP_081145.1  pygopus homolog 2 isoform b

    See identical proteins and their annotated locations for NP_081145.1

    Status: VALIDATED

    Source sequence(s)
    AI843615, AK132759
    Consensus CDS
    CCDS38494.1
    UniProtKB/TrEMBL
    Q3V113
    Related
    ENSMUSP00000103036.2, ENSMUST00000107413.2
    Conserved Domains (2) summary
    PRK14959
    Location:135 → 271
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    cd15636
    Location:291 → 344
    PHD_PYGO2; PHD finger found in pygopus homolog 2 (PYGO2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    89337521..89342438
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252785.1 → XP_030108645.1  pygopus homolog 2 isoform X1

    Conserved Domains (2) summary
    PRK14959
    Location:135 → 271
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    cd15636
    Location:291 → 344
    PHD_PYGO2; PHD finger found in pygopus homolog 2 (PYGO2)

  2. XM_030252784.2 → XP_030108644.1  pygopus homolog 2 isoform X1

    Conserved Domains (2) summary
    PRK14959
    Location:135 → 271
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    cd15636
    Location:291 → 344
    PHD_PYGO2; PHD finger found in pygopus homolog 2 (PYGO2)
Nucleotide Protein Strain
Heading Accession and Version

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