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Tatdn3 TatD DNase domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 68972, updated on 9-Dec-2024

Summary

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Official Symbol
Tatdn3provided by MGI
Official Full Name
TatD DNase domain containing 3provided by MGI
Primary source
MGI:MGI:1916222
See related
Ensembl:ENSMUSG00000026632 AllianceGenome:MGI:1916222
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1500010M24Rik
Summary
Predicted to enable metal ion binding activity and nuclease activity. Located in mitochondrion. Orthologous to human TATDN3 (TatD DNase domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 7.7), cortex adult (RPKM 7.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tatdn3 in Genome Data Viewer
Location:
1 H6; 1 96.28 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (190778023..190795373, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (191045826..191063075, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene feline leukemia virus subgroup C cellular receptor 1 Neighboring gene RIKEN cDNA A230020J21 gene Neighboring gene STARR-positive B cell enhancer ABC_E223 Neighboring gene spermatogenesis associated 45 Neighboring gene STARR-positive B cell enhancer ABC_E4404 Neighboring gene NSL1, MIS12 kinetochore complex component Neighboring gene basic leucine zipper transcription factor, ATF-like 3 Neighboring gene predicted gene, 46178

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
  2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative deoxyribonuclease TATDN3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163421.1 → NP_001156893.1  putative deoxyribonuclease TATDN3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region that results in a frameshift, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC138229
    Consensus CDS
    CCDS48486.1
    UniProtKB/TrEMBL
    D3Z0V5
    Related
    ENSMUSP00000106516.2, ENSMUST00000110891.8
    Conserved Domains (1) summary
    cd01310
    Location:5 → 223
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

  2. NM_001163422.1 → NP_001156894.1  putative deoxyribonuclease TATDN3 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon that results in a frameshift, compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC138229
    Consensus CDS
    CCDS48484.1
    UniProtKB/Swiss-Prot
    Q3U1C6
    Related
    ENSMUSP00000082773.6, ENSMUST00000085633.12
    Conserved Domains (1) summary
    cl00281
    Location:5 → 158
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

  3. NM_001357166.1 → NP_001344095.1  putative deoxyribonuclease TATDN3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC138229
    Consensus CDS
    CCDS87944.1
    UniProtKB/Swiss-Prot
    Q3U1C6, Q6P8H6, Q9DB58
    UniProtKB/TrEMBL
    D3YXH9
    Related
    ENSMUSP00000027945.6, ENSMUST00000027945.6
    Conserved Domains (1) summary
    cd01310
    Location:5 → 261
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

  4. NM_026895.1 → NP_081171.1  putative deoxyribonuclease TATDN3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC138229
    Consensus CDS
    CCDS48485.1
    UniProtKB/Swiss-Prot
    Q3U1C6, Q6P8H6, Q9DB58
    UniProtKB/TrEMBL
    E9QL22
    Related
    ENSMUSP00000106518.4, ENSMUST00000110893.10
    Conserved Domains (2) summary
    COG1099
    Location:6 → 262
    COG1099; Predicted metal-dependent hydrolase, TIM-barrel fold [General function prediction only]
    cd01310
    Location:5 → 262
    TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    190778023..190795373 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497204.5 → XP_006497267.1  putative deoxyribonuclease TATDN3 isoform X1

    Conserved Domains (1) summary
    cl00281
    Location:51 → 209
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U1C6.1 GenPept UniProtKB/Swiss-Prot:Q3U1C6

Gene LinkOut

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