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Snrpa1 small nuclear ribonucleoprotein polypeptide A' [ Mus musculus (house mouse) ]

Gene ID: 68981, updated on 9-Dec-2024

Summary

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Official Symbol
Snrpa1provided by MGI
Official Full Name
small nuclear ribonucleoprotein polypeptide A'provided by MGI
Primary source
MGI:MGI:1916231
See related
Ensembl:ENSMUSG00000030512 AllianceGenome:MGI:1916231
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1500015N06Rik
Summary
Predicted to enable U2 snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and spermatogenesis. Predicted to be located in nuclear speck. Predicted to be part of U2 snRNP; U2-type catalytic step 2 spliceosome; and U2-type precatalytic spliceosome. Is expressed in several structures, including central nervous system; hemolymphoid system; liver; metanephros; and sensory organ. Human ortholog(s) of this gene implicated in connective tissue disease. Orthologous to human SNRPA1 (small nuclear ribonucleoprotein polypeptide A'). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in CNS E11.5 (RPKM 37.4), liver E14 (RPKM 25.3) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Snrpa1 in Genome Data Viewer
Location:
7 C; 7 35.47 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (65710084..65724335)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (66060336..66074587)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_19072 Neighboring gene predicted gene 20684 Neighboring gene proprotein convertase subtilisin/kexin type 6 Neighboring gene STARR-seq mESC enhancer starr_19080 Neighboring gene predicted gene, 51486 Neighboring gene STARR-seq mESC enhancer starr_19081 Neighboring gene STARR-positive B cell enhancer ABC_E1088 Neighboring gene STARR-seq mESC enhancer starr_19082 Neighboring gene selenoprotein S Neighboring gene STARR-positive B cell enhancer ABC_E10440 Neighboring gene chondroitin sulfate synthase 1 Neighboring gene predicted gene, 23042

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning the cDNA for murine U2 snRNP-A' gene and its differential expression in lymphocyte development. Antica M, et al. Immunol Lett, 2002 Jul 3. PMID 12036604
  2. Alternative splicing events are a late feature of pathology in a mouse model of spinal muscular atrophy. Bäumer D, et al. PLoS Genet, 2009 Dec. PMID 20019802, Free PMC Article
  3. Genetic mapping of putative Chrna7 and Luzp2 neuronal transcriptional enhancers due to impact of a transgene-insertion and 6.8 Mb deletion in a mouse model of Prader-Willi and Angelman syndromes. Stefan M, et al. BMC Genomics, 2005 Nov 9. PMID 16280085, Free PMC Article
  4. The periphilin 1-like BFAR isoform 3 is highly expressed in transcriptionally silent oocytes and involved in RNA metabolism. Mrowiec K, et al. Biochim Biophys Acta Mol Cell Res, 2021 Sep. PMID 34175335
  5. STRAP regulates alternative splicing fidelity during lineage commitment of mouse embryonic stem cells. Jin L, et al. Nat Commun, 2020 Nov 23. PMID 33230114, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cloning the cDNA for murine U2 snRNP-A' gene and its differential expression in lymphocyte development
    Title: Cloning the cDNA for murine U2 snRNP-A' gene and its differential expression in lymphocyte development.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC6298, MGC25531

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables U2 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables U2 snRNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of U2 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2-type catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of U2-type catalytic step 2 spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of U2-type precatalytic spliceosome IEA
Inferred from Electronic Annotation
more info
  
part_of U2-type precatalytic spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of U2-type spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  
part_of U2-type spliceosomal complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
U2 small nuclear ribonucleoprotein A'
Names
U2 snRNP A'

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021336.4 → NP_067311.4  U2 small nuclear ribonucleoprotein A'

    See identical proteins and their annotated locations for NP_067311.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AC148973, AK153502
    Consensus CDS
    CCDS21342.1
    UniProtKB/Swiss-Prot
    P57784, Q3U7R8, Q8K2W4, Q91YW1, Q9JKQ3
    Related
    ENSMUSP00000117947.2, ENSMUST00000153609.8
    Conserved Domains (2) summary
    sd00031
    Location:22 → 43
    LRR_1; leucine-rich repeat [structural motif]
    pfam14580
    Location:1 → 175
    LRR_9; Leucine-rich repeat

RNA

  1. NR_152094.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC148973, AK005256, D18388
    Related
    ENSMUST00000032723.9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    65710084..65724335
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P57784.2 GenPept UniProtKB/Swiss-Prot:P57784

Gene LinkOut

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