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dek DEK proto-oncogene [ Danio rerio (zebrafish) ]

Gene ID: 692304, updated on 27-Dec-2024

Summary

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Official Symbol
dekprovided by ZNC
Official Full Name
DEK proto-oncogeneprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060512-191
See related
Ensembl:ENSDARG00000070108 AllianceGenome:ZFIN:ZDB-GENE-060512-191
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fb82g12; zgc:136346
Summary
Predicted to enable DNA binding activity. Predicted to act upstream of or within chromatin organization. Predicted to be located in nucleus. Orthologous to human DEK (DEK proto-oncogene). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See dek in Genome Data Viewer
Location:
chromosome: 16
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (41010978..41030634)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (41060936..41080602)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101885890 Neighboring gene glycogen synthase kinase binding protein Neighboring gene potassium voltage-gated channel modifier subfamily V member 1 Neighboring gene NF-kappa-B-activating protein-like Neighboring gene transfer RNA glutamic acid (anticodon CUC)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. An essential role of variant histone H3.3 for ectomesenchyme potential of the cranial neural crest. Cox SG, et al. PLoS Genet, 2012 Sep. PMID 23028350, Free PMC Article
  2. Single-cell analyses identify distinct and intermediate states of zebrafish pancreatic islet development. Lu CJ, et al. J Mol Cell Biol, 2019 Jun 1. PMID 30407522, Free PMC Article
  3. A live zebrafish-based screening system for human nuclear receptor ligand and cofactor discovery. Tiefenbach J, et al. PLoS One, 2010 Mar 22. PMID 20339547, Free PMC Article
  4. Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Raman R, et al. Sci Rep, 2021 Jul 27. PMID 34315984, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC174609

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein DEK
Names
DEK oncogene
DEK oncogene-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045276.2 → NP_001038741.2  protein DEK

    Status: VALIDATED

    Source sequence(s)
    BX511123
    UniProtKB/TrEMBL
    A0A8M1NAB4, F1R6C4
    Related
    ENSDARP00000058585.5, ENSDART00000058586.7
    Conserved Domains (1) summary
    pfam08766
    Location:390 → 442
    DEK_C; DEK C terminal domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    41010978..41030634
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009292539.4 → XP_009290814.1  protein DEK isoform X1

    See identical proteins and their annotated locations for XP_009290814.1

    UniProtKB/TrEMBL
    A0A8M3AID6
    Conserved Domains (1) summary
    pfam08766
    Location:394 → 446
    DEK_C; DEK C terminal domain

  2. XM_005158227.5 → XP_005158284.1  protein DEK isoform X1

    See identical proteins and their annotated locations for XP_005158284.1

    UniProtKB/TrEMBL
    A0A8M3AID6
    Conserved Domains (1) summary
    pfam08766
    Location:394 → 446
    DEK_C; DEK C terminal domain
Nucleotide Protein Strain
Heading Accession and Version

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