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Elf2 E74-like factor 2 [ Mus musculus (house mouse) ]

Gene ID: 69257, updated on 17-Aug-2024

Summary

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Official Symbol
Elf2provided by MGI
Official Full Name
E74-like factor 2provided by MGI
Primary source
MGI:MGI:1916507
See related
Ensembl:ENSMUSG00000037174 AllianceGenome:MGI:1916507
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EU32; NERF; NERF-2; NERF-1A; NERF-1B; 2610036A20Rik; A230104O07Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Predicted to be involved in cell differentiation and regulation of transcription, DNA-templated. Predicted to be located in cytosol and nuclear body. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human ELF2 (E74 like ETS transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 16.4), thymus adult (RPKM 9.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 C; 3 22.19 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (51160141..51248101, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (51252720..51340683, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07602 Neighboring gene predicted gene, 40044 Neighboring gene nocturnin Neighboring gene RIKEN cDNA 4930577N17 gene Neighboring gene STARR-positive B cell enhancer ABC_E148 Neighboring gene STARR-positive B cell enhancer ABC_E10178 Neighboring gene STARR-positive B cell enhancer ABC_E6050 Neighboring gene nuclear encoded tRNA proline 7 (anticodon TGG) Neighboring gene nuclear encoded tRNA proline 5 (anticodon AGG)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The antiproliferative ELF2 isoform, ELF2B, induces apoptosis in vitro and perturbs early lymphocytic development in vivo. Guan FH, et al. J Hematol Oncol, 2017 Mar 28. PMID 28351373, Free PMC Article
  2. Ets proteins in biological control and cancer. Hsu T, et al. J Cell Biochem, 2004 Apr 1. PMID 15034925, Free PMC Article
  3. An Elf2-like transcription factor acts as repressor of the mouse ecto-5'-nucleotidase gene expression in hepatic myofibroblasts. Fausther M, et al. Purinergic Signal, 2017 Dec. PMID 28667437, Free PMC Article
  4. Role of ets factors in the activity and endothelial cell specificity of the mouse Tie gene promoter. Iljin K, et al. FASEB J, 1999 Feb. PMID 9973326
  5. eIF2α phosphorylation controls thermal nociception. Khoutorsky A, et al. Proc Natl Acad Sci U S A, 2016 Oct 18. PMID 27698114, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC102660

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ETS-related transcription factor Elf-2
Names
ets domain transcription factor
ets family transcription factor ELF2A2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291059.1 → NP_001277988.1  ETS-related transcription factor Elf-2 isoform 2

    See identical proteins and their annotated locations for NP_001277988.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC118601, AC161183, AK146819
    Consensus CDS
    CCDS71242.1
    UniProtKB/TrEMBL
    Q3TVH6, Q58E60
    Related
    ENSMUSP00000061076.7, ENSMUST00000062009.14
    Conserved Domains (2) summary
    pfam00178
    Location:197 → 277
    Ets; Ets-domain
    pfam12310
    Location:3 → 108
    Elf-1_N; Transcription factor protein N terminal

  2. NM_001291062.1 → NP_001277991.1  ETS-related transcription factor Elf-2 isoform 3

    See identical proteins and their annotated locations for NP_001277991.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' structure and an alternate splice site in the coding region compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC118601, AC161183, AF256218
    Consensus CDS
    CCDS71240.1
    UniProtKB/TrEMBL
    A0A0B4J1G5
    Related
    ENSMUSP00000103686.2, ENSMUST00000108051.8
    Conserved Domains (2) summary
    pfam00178
    Location:138 → 217
    Ets; Ets-domain
    pfam12310
    Location:20 → 48
    Elf-1_N; Transcription factor protein N terminal

  3. NM_001291063.1 → NP_001277992.1  ETS-related transcription factor Elf-2 isoform 4

    See identical proteins and their annotated locations for NP_001277992.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate 5' structure compared to variant 1. The encoded isoform (4) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC118601, AC161183, AF256219
    Consensus CDS
    CCDS71241.1
    UniProtKB/TrEMBL
    A0A0B4J1G5
    Related
    ENSMUSP00000103688.3, ENSMUST00000108053.9
    Conserved Domains (2) summary
    pfam00178
    Location:150 → 229
    Ets; Ets-domain
    pfam12310
    Location:20 → 48
    Elf-1_N; Transcription factor protein N terminal

  4. NM_001356358.1 → NP_001343287.1  ETS-related transcription factor Elf-2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC118601, AC161183
    UniProtKB/TrEMBL
    A0A0B4J1G5
    Conserved Domains (2) summary
    pfam00178
    Location:118 → 198
    Ets; Ets-domain
    pfam12310
    Location:2 → 29
    Elf-1_N; Transcription factor protein N terminal

  5. NM_023502.2 → NP_075991.1  ETS-related transcription factor Elf-2 isoform 1

    See identical proteins and their annotated locations for NP_075991.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC118601, AC161183, AF256217
    Consensus CDS
    CCDS17337.1
    UniProtKB/Swiss-Prot
    Q6NST2, Q8BTX8, Q9JHC7, Q9JHC8, Q9JHC9, Q9JHD0
    UniProtKB/TrEMBL
    Q58E60
    Related
    ENSMUSP00000141197.2, ENSMUST00000194641.6
    Conserved Domains (2) summary
    pfam00178
    Location:209 → 289
    Ets; Ets-domain
    pfam12310
    Location:3 → 108
    Elf-1_N; Transcription factor protein N terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    51160141..51248101 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319714.3 → XP_017175203.1  ETS-related transcription factor Elf-2 isoform X5

    UniProtKB/TrEMBL
    Q3UZ20
    Conserved Domains (1) summary
    pfam00178
    Location:105 → 185
    Ets; Ets-domain

  2. XM_036163288.1 → XP_036019181.1  ETS-related transcription factor Elf-2 isoform X2

    UniProtKB/TrEMBL
    Q3TVH6, Q58E60
    Conserved Domains (2) summary
    pfam00178
    Location:197 → 277
    Ets; Ets-domain
    pfam12310
    Location:3 → 108
    Elf-1_N; Transcription factor protein N terminal

  3. XM_030252804.1 → XP_030108664.1  ETS-related transcription factor Elf-2 isoform X6

    UniProtKB/TrEMBL
    Q3UZ20
    Conserved Domains (1) summary
    pfam00178
    Location:94 → 173
    Ets; Ets-domain

  4. XM_036163287.1 → XP_036019180.1  ETS-related transcription factor Elf-2 isoform X1

    UniProtKB/Swiss-Prot
    Q6NST2, Q8BTX8, Q9JHC7, Q9JHC8, Q9JHC9, Q9JHD0
    UniProtKB/TrEMBL
    Q58E60
    Related
    ENSMUSP00000126871.2, ENSMUST00000163748.8
    Conserved Domains (2) summary
    pfam00178
    Location:209 → 289
    Ets; Ets-domain
    pfam12310
    Location:3 → 108
    Elf-1_N; Transcription factor protein N terminal

  5. XM_030252807.1 → XP_030108667.1  ETS-related transcription factor Elf-2 isoform X7

    UniProtKB/TrEMBL
    Q3UZ20
    Conserved Domains (1) summary
    pfam00178
    Location:74 → 154
    Ets; Ets-domain

  6. XM_006502031.4 → XP_006502094.1  ETS-related transcription factor Elf-2 isoform X3

    See identical proteins and their annotated locations for XP_006502094.1

    UniProtKB/TrEMBL
    A0A0B4J1G5
    Conserved Domains (2) summary
    pfam00178
    Location:130 → 210
    Ets; Ets-domain
    pfam12310
    Location:2 → 29
    Elf-1_N; Transcription factor protein N terminal

  7. XM_036163295.1 → XP_036019188.1  ETS-related transcription factor Elf-2 isoform X7

    UniProtKB/TrEMBL
    Q3UZ20
    Conserved Domains (1) summary
    pfam00178
    Location:74 → 154
    Ets; Ets-domain

  8. XM_036163291.1 → XP_036019184.1  ETS-related transcription factor Elf-2 isoform X4

    UniProtKB/TrEMBL
    A0A0B4J1G5
    Conserved Domains (2) summary
    pfam00178
    Location:118 → 198
    Ets; Ets-domain
    pfam12310
    Location:2 → 29
    Elf-1_N; Transcription factor protein N terminal

  9. XM_036163289.1 → XP_036019182.1  ETS-related transcription factor Elf-2 isoform X3

    UniProtKB/TrEMBL
    A0A0B4J1G5
    Conserved Domains (2) summary
    pfam00178
    Location:130 → 210
    Ets; Ets-domain
    pfam12310
    Location:2 → 29
    Elf-1_N; Transcription factor protein N terminal

  10. XM_036163290.1 → XP_036019183.1  ETS-related transcription factor Elf-2 isoform X3

    UniProtKB/TrEMBL
    A0A0B4J1G5
    Conserved Domains (2) summary
    pfam00178
    Location:130 → 210
    Ets; Ets-domain
    pfam12310
    Location:2 → 29
    Elf-1_N; Transcription factor protein N terminal

  11. XM_036163292.1 → XP_036019185.1  ETS-related transcription factor Elf-2 isoform X5

    UniProtKB/TrEMBL
    Q3UZ20
    Conserved Domains (1) summary
    pfam00178
    Location:105 → 185
    Ets; Ets-domain

  12. XM_030252805.1 → XP_030108665.1  ETS-related transcription factor Elf-2 isoform X6

    UniProtKB/TrEMBL
    Q3UZ20
    Conserved Domains (1) summary
    pfam00178
    Location:94 → 173
    Ets; Ets-domain

  13. XM_036163293.1 → XP_036019186.1  ETS-related transcription factor Elf-2 isoform X5

    UniProtKB/TrEMBL
    Q3UZ20
    Conserved Domains (1) summary
    pfam00178
    Location:105 → 185
    Ets; Ets-domain

  14. XM_030252806.1 → XP_030108666.1  ETS-related transcription factor Elf-2 isoform X7

    UniProtKB/TrEMBL
    Q3UZ20
    Conserved Domains (1) summary
    pfam00178
    Location:74 → 154
    Ets; Ets-domain

  15. XM_006502034.5 → XP_006502097.1  ETS-related transcription factor Elf-2 isoform X7

    See identical proteins and their annotated locations for XP_006502097.1

    UniProtKB/TrEMBL
    Q3UZ20
    Conserved Domains (1) summary
    pfam00178
    Location:74 → 154
    Ets; Ets-domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JHC9.1 GenPept UniProtKB/Swiss-Prot:Q9JHC9

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