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Glrx2 glutaredoxin 2 [ Mus musculus (house mouse) ]

Gene ID: 69367, updated on 2-Nov-2024

Summary

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Official Symbol
Glrx2provided by MGI
Official Full Name
glutaredoxin 2provided by MGI
Primary source
MGI:MGI:1916617
See related
Ensembl:ENSMUSG00000018196 AllianceGenome:MGI:1916617
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Grx2; 1700010P22Rik
Summary
Enables protein-disulfide reductase activity. Located in mitochondrion. Is expressed in several structures, including adrenal gland; alimentary system; genitourinary system; nervous system; and respiratory system. Orthologous to human GLRX2 (glutaredoxin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E18 (RPKM 6.6), frontal lobe adult (RPKM 6.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Glrx2 in Genome Data Viewer
Location:
1 F; 1 62.53 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (143614787..143625416)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (143739224..143749678)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene cell division cycle 73, Paf1/RNA polymerase II complex component Neighboring gene STARR-positive B cell enhancer ABC_E7755 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_02529 Neighboring gene predicted gene, 38658 Neighboring gene predicted gene, 46161 Neighboring gene Ro60, Y RNA binding protein Neighboring gene STARR-positive B cell enhancer ABC_E1564 Neighboring gene STARR-positive B cell enhancer ABC_E2564 Neighboring gene predicted gene, 25663 Neighboring gene ubiquitin carboxyl-terminal esterase L5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deletion of the Glutaredoxin-2 Gene Protects Mice from Diet-Induced Weight Gain, Which Correlates with Increased Mitochondrial Respiration and Proton Leaks in Skeletal Muscle. Young A, et al. Antioxid Redox Signal, 2019 Dec. PMID 31317766
  2. Glutaredoxin 2 (Grx2) gene deletion induces early onset of age-dependent cataracts in mice. Wu H, et al. J Biol Chem, 2014 Dec 26. PMID 25362663, Free PMC Article
  3. Glutaredoxin-2 is required to control oxidative phosphorylation in cardiac muscle by mediating deglutathionylation reactions. Mailloux RJ, et al. J Biol Chem, 2014 May 23. PMID 24727547, Free PMC Article
  4. Glutaredoxin 2 knockout increases sensitivity to oxidative stress in mouse lens epithelial cells. Wu H, et al. Free Radic Biol Med, 2011 Dec 1. PMID 21983434, Free PMC Article
  5. Pericyte loss via glutaredoxin2 downregulation aggravates diabetes-induced microvascular dysfunction. Li C, et al. Exp Eye Res, 2024 Oct. PMID 39117135

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pericyte loss via glutaredoxin2 downregulation aggravates diabetes-induced microvascular dysfunction.
    Title: Pericyte loss via glutaredoxin2 downregulation aggravates diabetes-induced microvascular dysfunction.
  2. Glutaredoxin 2 protects lens epithelial cells from epithelial-mesenchymal transition by suppressing mitochondrial oxidative stress-related upregulation of integrin-linked kinase.
    Title: Glutaredoxin 2 protects lens epithelial cells from epithelial-mesenchymal transition by suppressing mitochondrial oxidative stress-related upregulation of integrin-linked kinase.
  3. The impact of glutaredoxin 1 and glutaredoxin 2 double knockout on lens epithelial cell function.
    Title: The impact of glutaredoxin 1 and glutaredoxin 2 double knockout on lens epithelial cell function.
  4. Mitochondrial depletion of glutaredoxin 2 induces metabolic dysfunction-associated fatty liver disease in mice.
    Title: Mitochondrial depletion of glutaredoxin 2 induces metabolic dysfunction-associated fatty liver disease in mice.
  5. Upregulation of Glutaredoxin 2 alleviates oxygen-glucose deprivation/reoxygenation-induced apoptosis and ROS production in neurons by enhancing Nrf2 signaling via modulation of GSK-3beta.
    Title: Upregulation of Glutaredoxin 2 alleviates oxygen-glucose deprivation/reoxygenation-induced apoptosis and ROS production in neurons by enhancing Nrf2 signaling via modulation of GSK-3β.
  6. An investigation into the impact of deleting one copy of the glutaredoxin-2 gene on diet-induced weight gain and the bioenergetics of muscle mitochondria in female mice fed a high fat diet.
    Title: An investigation into the impact of deleting one copy of the glutaredoxin-2 gene on diet-induced weight gain and the bioenergetics of muscle mitochondria in female mice fed a high fat diet.
  7. Glutaredoxin 2 protects cardiomyocytes from hypoxia/reoxygenation-induced injury by suppressing apoptosis, oxidative stress, and inflammation via enhancing Nrf2 signaling.
    Title: Glutaredoxin 2 protects cardiomyocytes from hypoxia/reoxygenation-induced injury by suppressing apoptosis, oxidative stress, and inflammation via enhancing Nrf2 signaling.
  8. Glutaredoxin-2 and Sirtuin-3 deficiencies impair cardiac mitochondrial energetics but their effects are not additive.
    Title: Glutaredoxin-2 and Sirtuin-3 deficiencies impair cardiac mitochondrial energetics but their effects are not additive.
  9. The deleting the Grx2 gene can protect from diet-induced weight gain and the development of obesity-related disorders.
    Title: Deletion of the Glutaredoxin-2 Gene Protects Mice from Diet-Induced Weight Gain, Which Correlates with Increased Mitochondrial Respiration and Proton Leaks in Skeletal Muscle.
  10. ur results demonstrate that the GRX2-mediated regulation of O2(*-)/H2O2 release through the S-glutathionylation of mitochondrial proteins may play an integral role in controlling cellular ROS signaling
    Title: Characterization of the impact of glutaredoxin-2 (GRX2) deficiency on superoxide/hydrogen peroxide release from cardiac and liver mitochondria.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-disulfide reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-disulfide reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
glutaredoxin-2, mitochondrial
Names
thioltransferase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038592.1 → NP_001033681.1  glutaredoxin-2, mitochondrial isoform a

    See identical proteins and their annotated locations for NP_001033681.1

    Status: VALIDATED

    Source sequence(s)
    AK005853, AL592403, BY226480
    Consensus CDS
    CCDS15343.1
    UniProtKB/Swiss-Prot
    Q923X4, Q9DAG8, Q9JHY6
    UniProtKB/TrEMBL
    A2A5W4
    Related
    ENSMUSP00000141022.2, ENSMUST00000185362.7
    Conserved Domains (1) summary
    cd03419
    Location:61 → 142
    GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...

  2. NM_001038593.1 → NP_001033682.1  glutaredoxin-2, mitochondrial isoform b

    See identical proteins and their annotated locations for NP_001033682.1

    Status: VALIDATED

    Source sequence(s)
    AK005853, AL592403
    Consensus CDS
    CCDS15344.1
    UniProtKB/TrEMBL
    Q3UQ95
    Related
    ENSMUSP00000121665.2, ENSMUST00000145969.8
    Conserved Domains (1) summary
    cd03419
    Location:28 → 109
    GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...

  3. NM_001038594.1 → NP_001033683.1  glutaredoxin-2, mitochondrial isoform b

    See identical proteins and their annotated locations for NP_001033683.1

    Status: VALIDATED

    Source sequence(s)
    AK005853, AK142654, AL592403
    Consensus CDS
    CCDS15344.1
    UniProtKB/TrEMBL
    Q3UQ95
    Related
    ENSMUSP00000121010.2, ENSMUST00000129653.3
    Conserved Domains (1) summary
    cd03419
    Location:28 → 109
    GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...

  4. NM_023505.2 → NP_075994.2  glutaredoxin-2, mitochondrial isoform b

    See identical proteins and their annotated locations for NP_075994.2

    Status: VALIDATED

    Source sequence(s)
    AK005853, AL592403
    Consensus CDS
    CCDS15344.1
    UniProtKB/TrEMBL
    Q3UQ95
    Related
    ENSMUSP00000107588.4, ENSMUST00000111957.10
    Conserved Domains (1) summary
    cd03419
    Location:28 → 109
    GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    143614787..143625416
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529856.3 → XP_006529919.1  glutaredoxin-2, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006529919.1

    UniProtKB/TrEMBL
    Q3UQ95
    Conserved Domains (1) summary
    cd03419
    Location:28 → 109
    GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...

  2. XM_006529855.5 → XP_006529918.2  glutaredoxin-2, mitochondrial isoform X1

  3. XM_011248068.3 → XP_011246370.1  glutaredoxin-2, mitochondrial isoform X3

    Conserved Domains (1) summary
    cd03419
    Location:19 → 100
    GRX_GRXh_1_2_like; Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q923X4.1 GenPept UniProtKB/Swiss-Prot:Q923X4

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