Tcf23 transcription factor 23 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tcf23provided by MGI
Official Full Name: transcription factor 23provided by MGI
Primary source: MGI:MGI:1934960
See related: Ensembl:ENSMUSG00000006642 AllianceGenome:MGI:1934960
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Out; bHLHa24; 2010002O16Rik
Summary: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription regulator inhibitor activity. Involved in negative regulation of muscle cell differentiation and negative regulation of transcription by RNA polymerase II. Located in euchromatin. Is expressed in central nervous system and genitourinary system. Orthologous to human TCF23 (transcription factor 23). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in stomach adult (RPKM 8.3), ovary adult (RPKM 6.2) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B1; 5 16.9 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (31125946..31145406)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (30968602..30988062)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transcription Factor 23 is an Essential Determinant of Murine Term Parturition.
Title: Transcription Factor 23 is an Essential Determinant of Murine Term Parturition.
transcription factor 23 (Tcf23), a basic-helix-loop-helix transcription factor, is a new progesterone-induced target gene that requires SRC-2 for full induction.
Title: A murine uterine transcriptome, responsive to steroid receptor coactivator-2, reveals transcription factor 23 as essential for decidualization of human endometrial stromal cells.
genomic organization and chromosome 2 mapping
Title: Genomic organization and chromosomal mapping of the basic helix-loop-helix factor OUT (Tcf23/TCF23).

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:491529

RH118284 (e-PCR)
- UniSTS:159356

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables transcription regulator inhibitor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within decidualization	ISO Inferred from Sequence Orthology more info	PubMed
involved_in developmental process	IBA Inferred from Biological aspect of Ancestor more info
involved_in muscle organ development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of muscle cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in euchromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transcription factor 23

Names: TCF-23; basic helix-loop-helix transcription factor OUT; ovary, uterus and testis protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053085.2 → NP_444315.1 transcription factor 23

See identical proteins and their annotated locations for NP_444315.1

Status: PROVISIONAL

Source sequence(s)

AC109606

Consensus CDS

CCDS19168.1

UniProtKB/Swiss-Prot

Q9JLR5

Related

ENSMUSP00000006818.3, ENSMUST00000006818.4

Conserved Domains (1) summary

smart00353
Location:82 → 131

HLH; helix loop helix domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

31125946..31145406

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006504095.4 → XP_006504158.1 transcription factor 23 isoform X1

Conserved Domains (1) summary

cd19709
Location:77 → 132

bHLH_TS_TCF23_OUT; basic helix-loop-helix (bHLH) domain found in transcription factor 23 (TCF-23) and similar proteins
XM_006504096.4 → XP_006504159.1 transcription factor 23 isoform X2

Conserved Domains (1) summary

cd19709
Location:33 → 88

bHLH_TS_TCF23_OUT; basic helix-loop-helix (bHLH) domain found in transcription factor 23 (TCF-23) and similar proteins