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RVA_s11_gp1 NSP5 [ Rotavirus A ]

Gene ID: 7011364, updated on 18-Aug-2023

Summary

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Gene symbol
RVA_s11_gp1
Gene description
NSP5
Locus tag
RVA_s11_gp1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rotavirus A (strain: RVA/Simian-tc/ZAF/SA11-H96/1958/G3P5B[2], serotype: G3)
Lineage
Viruses; dsRNA viruses; Reoviridae; Sedoreovirinae; Rotavirus
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Genomic context

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Location:
segment: 11
Sequence:
NC_011505.2 (22..618)

NC_011505.2Genomic Context describing neighboring genes Neighboring gene NSP6

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_011505.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Recombinant Rotaviruses Rescued by Reverse Genetics Reveal the Role of NSP5 Hyperphosphorylation in the Assembly of Viral Factories. Papa G, et al. J Virol, 2019 Dec 12. PMID 31619556, Free PMC Article
  2. Structural organisation of the rotavirus nonstructural protein NSP5. Martin D, et al. J Mol Biol, 2011 Oct 14. PMID 21864538
  3. Analysis of rotavirus non-structural protein NSP5 by mass spectrometry reveals a complex phosphorylation pattern. Sotelo PH, et al. Virus Res, 2010 Apr. PMID 20036292
  4. Liquid-liquid phase separation underpins the formation of replication factories in rotaviruses. Geiger F, et al. EMBO J, 2021 Nov 2. PMID 34524703, Free PMC Article
  5. A novel form of rotavirus NSP2 and phosphorylation-dependent NSP2-NSP5 interactions are associated with viroplasm assembly. Criglar JM, et al. J Virol, 2014 Jan. PMID 24198401, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Liquid-liquid phase separation underpins the formation of replication factories in rotaviruses.
    Title: Liquid-liquid phase separation underpins the formation of replication factories in rotaviruses.
  2. NSP5 hyperphosphorylation is a crucial step for the assembly of round-shaped viroplasms, highlighting the key role of the C-terminal tail of NSP5 in the formation of replication-competent viral factories. Such a complex NSP5 phosphorylation cascade may serve as a paradigm for the assembly of functional viral factories in other RNA viruses.
    Title: Recombinant Rotaviruses Rescued by Reverse Genetics Reveal the Role of NSP5 Hyperphosphorylation in the Assembly of Viral Factories.
  3. Phosphorylation-dependent NSP2-NSP5 interactions are associated with viroplasm assembly.
    Title: A novel form of rotavirus NSP2 and phosphorylation-dependent NSP2-NSP5 interactions are associated with viroplasm assembly.
  4. The first region, residues 103-146, is involved in NSP5 dimerisation, whereas the second region, residues 189-198, is responsible for NSP5 decamerisation.
    Title: Structural organisation of the rotavirus nonstructural protein NSP5.
  5. The authors obtained NSP5 from infected cells and by mass spectrometry we were able to identify nine phosphorylation sites.
    Title: Analysis of rotavirus non-structural protein NSP5 by mass spectrometry reveals a complex phosphorylation pattern.
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General gene information

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Homology

General protein information

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Preferred Names
NSP5

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_011505.2 Reference assembly

    Range
    22..618
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_002302224.1 NSP5 [Rotavirus A]

    See identical proteins and their annotated locations for YP_002302224.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    A2T3Q9, P11202
    UniProtKB/TrEMBL
    A0A0C5BMY3, A2T3Q1, F8UF73, G4XR50, Q71SB3
    Conserved Domains (1) summary
    pfam01525
    Location:10 → 198
    Rota_NS26; Rotavirus NS26
Nucleotide Protein
Heading Accession and Version

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