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RVA_s4_g p1 VP4 [ Rotavirus A ]

Gene ID: 7011406, updated on 18-Aug-2023

Summary

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Gene symbol
RVA_s4_g p1
Gene description
VP4
Locus tag
RVA_s4_g p1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rotavirus A (strain: RVA/Simian-tc/ZAF/SA11-H96/1958/G3P5B[2], serotype: G3)
Lineage
Viruses; dsRNA viruses; Reoviridae; Sedoreovirinae; Rotavirus
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Genomic context

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Location:
segment: 4
Sequence:
NC_011510.2 (10..2340)

NC_011510.2Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_011510.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Generation and characterization of mouse monoclonal antibodies against the VP4 protein of group A human rotaviruses. Zeng Y, et al. Antiviral Res, 2022 Nov. PMID 36152816
  2. Amino Acid Substitutions in Positions 385 and 393 of the Hydrophobic Region of VP4 May Be Associated with Rotavirus Attenuation and Cell Culture Adaptation. Guo Y, et al. Viruses, 2020 Apr 7. PMID 32272747, Free PMC Article
  3. Genetic analysis of Ghanaian G1P[8] and G9P[8] rotavirus A strains reveals the impact of P[8] VP4 gene polymorphism on P-genotyping. Damanka SA, et al. PLoS One, 2019. PMID 31242245, Free PMC Article
  4. Prevalence of human rotavirus genotypes in Wuhan, China, during 2008-2011: changing trend of predominant genotypes and emergence of strains with the P[8]b subtype of the VP4 gene. Wang YH, et al. Arch Virol, 2011 Dec. PMID 21986895
  5. Genome heterogeneity of SA11 rotavirus due to reassortment with "O" agent. Small C, et al. Virology, 2007 Mar 15. PMID 17059839, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Generation and characterization of mouse monoclonal antibodies against the VP4 protein of group A human rotaviruses.
    Title: Generation and characterization of mouse monoclonal antibodies against the VP4 protein of group A human rotaviruses.
  2. Amino Acid Substitutions in Positions 385 and 393 of the Hydrophobic Region of VP4 May Be Associated with Rotavirus Attenuation and Cell Culture Adaptation.
    Title: Amino Acid Substitutions in Positions 385 and 393 of the Hydrophobic Region of VP4 May Be Associated with Rotavirus Attenuation and Cell Culture Adaptation.
  3. Near-full-length VP7 gene and the VP8* fragment of the VP4 gene were obtained by Sanger sequencing and genotypes were determined using RotaC v2.0 web-based genotyping tool. Phylogenetic analysis of the P[8]a sequences placed them in subcluster IIIc within lineage III together with contemporary G1P[8], G3P[8], G8P[8], and G9P[8] strains detected globally from 2006-2016.
    Title: Genetic analysis of Ghanaian G1P[8] and G9P[8] rotavirus A strains reveals the impact of P[8] VP4 gene polymorphism on P-genotyping.
  4. The full-length sequence of VP4 gene segments of the P[8]b strains in Wuhan clustered with those of P[8]b strains in Vietnam, Russia and Belgium, while they were distinct from those of the OP354 strain from Malawi and Bangladeshi strains.
    Title: Prevalence of human rotavirus genotypes in Wuhan, China, during 2008-2011: changing trend of predominant genotypes and emergence of strains with the P[8]b subtype of the VP4 gene.
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General gene information

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Homology

General protein information

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Preferred Names
outer capsid spike protein VP4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_011510.2 Reference assembly

    Range
    10..2340
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_002302230.1 outer capsid spike protein VP4 [Rotavirus A]

    See identical proteins and their annotated locations for YP_002302230.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    A2T3T2, P12976
    UniProtKB/TrEMBL
    A0A1Q2TSK9, A0A5J6BCJ8
    Conserved Domains (3) summary
    pfam00426
    Location:65 → 224
    VP4_haemagglut; Outer Capsid protein VP4 (Hemagglutinin) Concanavalin-like domain
    pfam17478
    Location:486 → 776
    VP4_helical; Rotavirus VP4 helical domain
    pfam17477
    Location:250 → 474
    Rota_VP4_MID; Rotavirus VP4 membrane interaction domain
Nucleotide Protein
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