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Yars2 tyrosyl-tRNA synthetase 2 (mitochondrial) [ Mus musculus (house mouse) ]

Gene ID: 70120, updated on 9-Dec-2024

Summary

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Official Symbol
Yars2provided by MGI
Official Full Name
tyrosyl-tRNA synthetase 2 (mitochondrial)provided by MGI
Primary source
MGI:MGI:1917370
See related
Ensembl:ENSMUSG00000022792 AllianceGenome:MGI:1917370
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
tyrRS; 2210023C10Rik
Summary
Predicted to enable several functions, including L-tyrosine binding activity; protein homodimerization activity; and tyrosine-tRNA ligase activity. Predicted to be involved in mitochondrial tyrosyl-tRNA aminoacylation. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and respiratory system. Human ortholog(s) of this gene implicated in myopathy, lactic acidosis, and sideroblastic anemia 2. Orthologous to human YARS2 (tyrosyl-tRNA synthetase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 30.6), ovary adult (RPKM 17.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Yars2 in Genome Data Viewer
Location:
16 A2; 16 10.11 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (16120829..16127504)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (16302965..16309640)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene plakophilin 2 Neighboring gene ribosomal protein L30 pseudogene Neighboring gene dynamin 1-like Neighboring gene STARR-seq mESC enhancer starr_40229 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner. Zurkirchen L, et al. Nat Commun, 2019 May 16. PMID 31097699, Free PMC Article
  2. The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes. Liu F, et al. Mol Cell Proteomics, 2018 Feb. PMID 29222160, Free PMC Article
  3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables L-tyrosine binding IEA
Inferred from Electronic Annotation
more info
  
enables L-tyrosine binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables tyrosine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tyrosine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables tyrosine-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mitochondrial tyrosyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial tyrosyl-tRNA aminoacylation ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA aminoacylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tyrosine--tRNA ligase, mitochondrial
NP_937889.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198246.2 → NP_937889.1  tyrosine--tRNA ligase, mitochondrial

    See identical proteins and their annotated locations for NP_937889.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes a functional protein.
    Source sequence(s)
    AC112943, AK083653, BC060295
    Consensus CDS
    CCDS27983.1
    UniProtKB/Swiss-Prot
    Q6PAH7, Q8BYL4
    Related
    ENSMUSP00000055277.9, ENSMUST00000059955.15
    Conserved Domains (2) summary
    cd00805
    Location:69 → 351
    TyrRS_core; catalytic core domain of tyrosinyl-tRNA synthetase
    PRK05912
    Location:37 → 469
    PRK05912; tyrosyl-tRNA synthetase; Validated

RNA

  1. NR_038046.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC112943, AK138504
    Related
    ENSMUST00000159683.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    16120829..16127504
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BYL4.2 GenPept UniProtKB/Swiss-Prot:Q8BYL4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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