Crtc3 CREB regulated transcription coactivator 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Crtc3provided by MGI
Official Full Name: CREB regulated transcription coactivator 3provided by MGI
Primary source: MGI:MGI:1917711
See related: Ensembl:ENSMUSG00000030527 AllianceGenome:MGI:1917711
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TORC3; 2610312F20Rik; 6332415K15Rik
Summary: Predicted to enable cAMP response element binding protein binding activity and transcription coactivator activity. Involved in positive regulation of CREB transcription factor activity. Acts upstream of or within several processes, including energy homeostasis; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Orthologous to human CRTC3 (CREB regulated transcription coactivator 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 17.1), ovary adult (RPKM 16.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 D2- D3; 7 45.65 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (80236375..80339443, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (80586627..80688948, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Amphiregulin normalizes altered circuit connectivity for social dominance of the CRTC3 knockout mouse.
Title: Amphiregulin normalizes altered circuit connectivity for social dominance of the CRTC3 knockout mouse.
CRTC3, a sensor and key regulator for melanogenesis, as a tunable therapeutic target for pigmentary disorders.
Title: CRTC3, a sensor and key regulator for melanogenesis, as a tunable therapeutic target for pigmentary disorders.
The results demonstrate that the localization of CRTC3 involves in regulating cold-induced upregulation of UCP1 in BAT and provide useful information for understanding the molecular regulation of BAT thermogenesis induced by a cold environment.
Title: Cold exposure induces nuclear translocation of CRTC3 in brown adipose tissue.
CRTC3 reduced sympathetic nerve activity in BAT by up-regulating the expression of miR-206, a microRNA that promotes differentiation along the myogenic lineage and that we show here decreases the expression of VEGFA and neurotrophins critical for BAT innervation and vascularization.
Title: cAMP-inducible coactivator CRTC3 attenuates brown adipose tissue thermogenesis.
Deletion of Lkb1 results in a cytoplasm to nuclear translocation of CRTC3 in brown adipocytes, where it recruits C/EBPbeta to enhance Ucp1 transcription.
Title: Lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3.
These results demonstrate how cross-coupling between the CREB/CRTC and JAK/STAT pathways contributes to bone marrow homeostasis.
Title: CREB coactivators CRTC2 and CRTC3 modulate bone marrow hematopoiesis.
the existence of an unusual functional interplay between STATs and CREB at the onset of adipogenesis through shared CRTC cofactors, is reported.
Title: MDM2 facilitates adipocyte differentiation through CRTC-mediated activation of STAT3.
Three mouse CRTCs (Crtc1, Crtc2 and Crtc3) exhibit distinct patterns of 14-3-3 binding at three conserved sites corresponding to S70, S171, and S275 (in CRTC2).
Title: Analysis of a cAMP regulated coactivator family reveals an alternative phosphorylation motif for AMPK family members.
beta-agonists or catecholamines released during intense exercise induce Creb-mediated transcriptional programs through activation of its obligate coactivators Crtc2 and Crtc3.
Title: Creb coactivators direct anabolic responses and enhance performance of skeletal muscle.
CRTC3 plays a selective role in mitochondrial biogenesis in response to rotenone
Title: Role of cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 3 (CRTC3) in the initiation of mitochondrial biogenesis and stress response in liver cells.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7Dmr1 (e-PCR), detects polymorphism
- UniSTS:178181

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

AI429792 (e-PCR)
- UniSTS:159655

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cAMP response element binding protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables cAMP response element binding protein binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to cAMP	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within energy homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of lipid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macrophage activation	IEA Inferred from Electronic Annotation more info
involved_in macrophage activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of lipid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of CREB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in protein homotetramerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: CREB-regulated transcription coactivator 3

Names: TORC-3; transducer of CREB protein 3; transducer of regulated cAMP response element-binding protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173863.3 → NP_776288.2 CREB-regulated transcription coactivator 3

See identical proteins and their annotated locations for NP_776288.2

Status: VALIDATED

Source sequence(s)

AC127594

Consensus CDS

CCDS21398.2

UniProtKB/Swiss-Prot

Q91X84

Related

ENSMUSP00000113540.2, ENSMUST00000122255.8

Conserved Domains (3) summary

pfam12884
Location:11 → 64

TORC_N; Transducer of regulated CREB activity, N terminus

pfam12885
Location:159 → 321

TORC_M; Transducer of regulated CREB activity middle domain

pfam12886
Location:545 → 619

TORC_C; Transducer of regulated CREB activity, C terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

80236375..80339443 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030242981.2 → XP_030098841.1 CREB-regulated transcription coactivator 3 isoform X2

Conserved Domains (3) summary

PRK10263
Location:88 → 234

PRK10263; DNA translocase FtsK; Provisional

pfam12885
Location:1 → 22

TORC_M; Transducer of regulated CREB activity middle domain

pfam12886
Location:246 → 320

TORC_C; Transducer of regulated CREB activity, C-terminus
XM_006541195.4 → XP_006541258.1 CREB-regulated transcription coactivator 3 isoform X1

Conserved Domains (4) summary

PRK10263
Location:386 → 532

PRK10263; DNA translocase FtsK; Provisional

pfam12884
Location:11 → 64

TORC_N; Transducer of regulated CREB activity, N-terminus

pfam12885
Location:159 → 320

TORC_M; Transducer of regulated CREB activity middle domain

pfam12886
Location:544 → 618

TORC_C; Transducer of regulated CREB activity, C-terminus