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Gpr137c G protein-coupled receptor 137C [ Mus musculus (house mouse) ]

Gene ID: 70713, updated on 2-Nov-2024

Summary

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Official Symbol
Gpr137cprovided by MGI
Official Full Name
G protein-coupled receptor 137Cprovided by MGI
Primary source
MGI:MGI:1917963
See related
Ensembl:ENSMUSG00000049092 AllianceGenome:MGI:1917963
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm908; TM7SF1L2; 6330416L11Rik
Summary
Predicted to be involved in positive regulation of TORC1 signaling. Predicted to be active in lysosomal membrane. Orthologous to human GPR137C (G protein-coupled receptor 137C). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in cerebellum adult (RPKM 4.5), whole brain E14.5 (RPKM 3.6) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See Gpr137c in Genome Data Viewer
Location:
14 C1; 14 22.82 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (45457142..45520192)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (45219685..45282735)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene thioredoxin domain containing 16 Neighboring gene predicted gene, 34362 Neighboring gene STARR-positive B cell enhancer ABC_E95 Neighboring gene tubulin, beta 6 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr14:45861577-45861878 Neighboring gene endoplasmic reticulum oxidoreductase 1 alpha Neighboring gene STARR-positive B cell enhancer ABC_E3110 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:45949463-45949646 Neighboring gene proteasome (prosome, macropain) 26S subunit, ATPase, 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The G protein-coupled receptor repertoires of human and mouse. Vassilatis DK, et al. Proc Natl Acad Sci U S A, 2003 Apr 15. PMID 12679517, Free PMC Article
  2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in positive regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
G protein-coupled receptor 137C
Names
G protein-coupled receptor TM7SF1L2
integral membrane protein GPR137C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027518.2 → NP_081794.2  G protein-coupled receptor 137C

    Status: VALIDATED

    Source sequence(s)
    AC154575
    Consensus CDS
    CCDS49464.1
    UniProtKB/Swiss-Prot
    E9Q343
    Related
    ENSMUSP00000120015.2, ENSMUST00000146150.3
    Conserved Domains (2) summary
    cd21464
    Location:44 → 66
    7tm_GPR137; TM helix 1 [structural motif]
    cl28897
    Location:36 → 357
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    45457142..45520192
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519544.4 → XP_006519607.1  G protein-coupled receptor 137C isoform X1

  2. XM_017316191.3 → XP_017171680.1  G protein-coupled receptor 137C isoform X3

    UniProtKB/TrEMBL
    A0A2I3BPD5, A0A2I3BPS9
    Related
    ENSMUSP00000153737.2, ENSMUST00000227009.2

  3. XM_017316190.2 → XP_017171679.1  G protein-coupled receptor 137C isoform X2

    UniProtKB/TrEMBL
    A0A2I3BPS9
    Related
    ENSMUSP00000153906.2, ENSMUST00000227056.2

  4. XM_017316192.2 → XP_017171681.1  G protein-coupled receptor 137C isoform X4

    UniProtKB/TrEMBL
    A0A2I3BPS9

RNA

  1. XR_004938445.1 RNA Sequence

  2. XR_874367.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9Q343.1 GenPept UniProtKB/Swiss-Prot:E9Q343

Gene LinkOut

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