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Rasgef1a RasGEF domain family, member 1A [ Mus musculus (house mouse) ]

Gene ID: 70727, updated on 9-Dec-2024

Summary

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Official Symbol
Rasgef1aprovided by MGI
Official Full Name
RasGEF domain family, member 1Aprovided by MGI
Primary source
MGI:MGI:1917977
See related
Ensembl:ENSMUSG00000030134 AllianceGenome:MGI:1917977
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6330404M18Rik
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction; cell migration; and positive regulation of Ras protein signal transduction. Predicted to be active in plasma membrane. Is expressed in amygdala; olfactory epithelium; telencephalon mantle layer; and vomeronasal organ. Orthologous to human RASGEF1A (RasGEF domain family member 1A). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in frontal lobe adult (RPKM 25.3), cortex adult (RPKM 24.6) and 3 other tissues See more
Orthologs
human all
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Genomic context

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See Rasgef1a in Genome Data Viewer
Location:
6 F1; 6 55.85 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (117988466..118068507)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (118011505..118091546)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_17129 Neighboring gene FXYD domain-containing ion transport regulator 4 Neighboring gene STARR-seq mESC enhancer starr_17131 Neighboring gene predicted gene, 38884 Neighboring gene Lasp1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_17132 Neighboring gene STARR-seq mESC enhancer starr_17134 Neighboring gene microRNA 7044 Neighboring gene chondroitin sulfate N-acetylgalactosaminyltransferase 2 Neighboring gene predicted gene, 23908 Neighboring gene STARR-positive B cell enhancer ABC_E6475 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:118117270-118117379 Neighboring gene STARR-positive B cell enhancer ABC_E2800 Neighboring gene ret proto-oncogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mapping brain gene coexpression in daytime transcriptomes unveils diurnal molecular networks and deciphers perturbation gene signatures. Wang N, et al. Neuron, 2022 Oct 19. PMID 36265442, Free PMC Article
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ras-GEF domain-containing family member 1A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316749.2 → NP_001303678.1  ras-GEF domain-containing family member 1A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction compared to variant 3. The resulting isoform (2) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 3. Variants 2 and 4 both encode the same isoform (2).
    Source sequence(s)
    AC135861
    Consensus CDS
    CCDS85141.1
    UniProtKB/TrEMBL
    A6H650, B7ZNG9, E9Q1N6
    Related
    ENSMUSP00000132244.3, ENSMUST00000164960.4
    Conserved Domains (2) summary
    cd06224
    Location:49 → 176
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    pfam00617
    Location:218 → 410
    RasGEF; RasGEF domain

  2. NM_001362103.1 → NP_001349032.1  ras-GEF domain-containing family member 1A isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3).
    Source sequence(s)
    AC135861
    Consensus CDS
    CCDS90110.1
    UniProtKB/TrEMBL
    A0A0N4SVR5, B7ZNG9
    Related
    ENSMUSP00000145214.2, ENSMUST00000203804.3
    Conserved Domains (2) summary
    cd06224
    Location:57 → 163
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    pfam00617
    Location:235 → 427
    RasGEF; RasGEF domain

  3. NM_001362104.1 → NP_001349033.1  ras-GEF domain-containing family member 1A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction compared to variant 3. The resulting isoform (2) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 3. Variants 2 and 4 both encode the same isoform (2).
    Source sequence(s)
    AC135861
    Consensus CDS
    CCDS85141.1
    UniProtKB/TrEMBL
    A6H650, B7ZNG9, E9Q1N6
    Conserved Domains (2) summary
    cd06224
    Location:49 → 176
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    pfam00617
    Location:218 → 410
    RasGEF; RasGEF domain

  4. NM_001362105.1 → NP_001349034.1  ras-GEF domain-containing family member 1A isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction compared to variant 3. The resulting isoform (4) has a longer and distinct N-terminus and lacks an alternate internal segment compared to isoform 3.
    Source sequence(s)
    AC135861
    UniProtKB/TrEMBL
    B7ZNG9
    Conserved Domains (2) summary
    cd06224
    Location:60 → 187
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    pfam00617
    Location:229 → 421
    RasGEF; RasGEF domain

  5. NM_027526.1 → NP_081802.1  ras-GEF domain-containing family member 1A isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice junction compared to variant 3. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 3.
    Source sequence(s)
    AK018120, AK158756, BY120855, BY256830
    Consensus CDS
    CCDS51883.1
    UniProtKB/TrEMBL
    A0A0N4SVF2, B7ZNG9
    Related
    ENSMUSP00000145077.2, ENSMUST00000203482.2
    Conserved Domains (2) summary
    cd06224
    Location:57 → 184
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:222 → 470
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    117988466..118068507
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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