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Klhl30 kelch-like 30 [ Mus musculus (house mouse) ]

Gene ID: 70788, updated on 13-Jan-2025

Summary

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Official Symbol
Klhl30provided by MGI
Official Full Name
kelch-like 30provided by MGI
Primary source
MGI:MGI:1918038
See related
Ensembl:ENSMUSG00000026308 AllianceGenome:MGI:1918038
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4631423F02Rik
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in branchial arch; chondrocranium; common atrial chamber; heart; and metanephros. Orthologous to human KLHL30 (kelch like family member 30). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in heart adult (RPKM 23.4), ovary adult (RPKM 5.5) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Klhl30 in Genome Data Viewer
Location:
1 D; 1 46.09 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (91278795..91290126)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (91351073..91362404)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E794 Neighboring gene selenocysteine lyase Neighboring gene espin-like Neighboring gene erythroferrone Neighboring gene integrin-linked kinase-associated serine/threonine phosphatase 2C Neighboring gene RIKEN cDNA 1700020N18 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse ES cell-derived cardiac precursor cells are multipotent and facilitate identification of novel cardiac genes. Christoforou N, et al. J Clin Invest, 2008 Mar. PMID 18246200, Free PMC Article
  2. Osteoblast-specific expression of Panx3 is dispensable for postnatal bone remodeling. Yorgan TA, et al. Bone, 2019 Oct. PMID 31202927
  3. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

General gene information

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Homology

Clone Names

  • MGC143856

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kelch-like protein 30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027551.2 → NP_081827.1  kelch-like protein 30

    See identical proteins and their annotated locations for NP_081827.1

    Status: PROVISIONAL

    Source sequence(s)
    AK086025
    Consensus CDS
    CCDS15161.1
    UniProtKB/Swiss-Prot
    Q8C3F7, Q9D692
    Related
    ENSMUSP00000027533.9, ENSMUST00000027533.9
    Conserved Domains (6) summary
    smart00612
    Location:329 → 378
    Kelch; Kelch domain
    PHA03098
    Location:29 → 494
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:319 → 364
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:23 → 127
    BTB; BTB/POZ domain
    pfam01344
    Location:367 → 408
    Kelch_1; Kelch motif
    pfam07707
    Location:135 → 237
    BACK; BTB And C-terminal Kelch

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    91278795..91290126
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C3F7.1 GenPept UniProtKB/Swiss-Prot:Q8C3F7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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