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Eva1c eva-1 homolog C [ Mus musculus (house mouse) ]

Gene ID: 70967, updated on 18-Sep-2024

Summary

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Official Symbol
Eva1cprovided by MGI
Official Full Name
eva-1 homolog Cprovided by MGI
Primary source
MGI:MGI:1918217
See related
Ensembl:ENSMUSG00000039903 AllianceGenome:MGI:1918217
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam176c; 1700092M14Rik; 4931408A02Rik
Summary
Predicted to enable heparin binding activity. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to colocalize with extracellular region. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human EVA1C (eva-1 homolog C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 10.3), lung adult (RPKM 2.6) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Eva1c in Genome Data Viewer
Location:
16 C3.3; 16 52.02 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (90623607..90701997)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (90826719..90905109)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene melanocortin 2 receptor accessory protein Neighboring gene STARR-seq mESC enhancer starr_41464 Neighboring gene URB1 ribosome biogenesis 1 homolog (S. cerevisiae) Neighboring gene STARR-positive B cell enhancer ABC_E1929 Neighboring gene predicted gene, 36363 Neighboring gene STARR-seq mESC enhancer starr_41466 Neighboring gene STARR-seq mESC enhancer starr_41467 Neighboring gene STARR-seq mESC enhancer starr_41468 Neighboring gene predicted gene, 53919 Neighboring gene STARR-positive B cell enhancer ABC_E4188 Neighboring gene cilia and flagella associate protien 298 Neighboring gene synaptojanin 1 Neighboring gene RIKEN cDNA 4930404I05 gene Neighboring gene STARR-positive B cell enhancer mm9_chr16:91012148-91012449

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The expression pattern of EVA1C, a novel Slit receptor, is consistent with an axon guidance role in the mouse nervous system. James G, et al. PLoS One, 2013. PMID 24040182, Free PMC Article
  2. EVA-1 functions as an UNC-40 Co-receptor to enhance attraction to the MADD-4 guidance cue in Caenorhabditis elegans. Chan KK, et al. PLoS Genet, 2014 Aug. PMID 25122090, Free PMC Article
  3. From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map. Reymond A, et al. Genomics, 2001 Nov. PMID 11707072
  4. Single-cell transcriptomics of the early developing mouse cerebral cortex disentangle the spatial and temporal components of neuronal fate acquisition. Moreau MX, et al. Development, 2021 Jul 15. PMID 34170322
  5. Regulatory pathway analysis by high-throughput in situ hybridization. Visel A, et al. PLoS Genet, 2007 Oct. PMID 17953485, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. we demonstrate that MADD-4 interacts with an EVA-1/UNC-40 co-receptor complex to attract cell extensions
    Title: EVA-1 functions as an UNC-40 Co-receptor to enhance attraction to the MADD-4 guidance cue in Caenorhabditis elegans.
  2. We report that EVA1C is expressed by axons contributing to commissures, tracts and nerve pathways of the developing spinal cord and forebrain.
    Title: The expression pattern of EVA1C, a novel Slit receptor, is consistent with an axon guidance role in the mouse nervous system.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

General gene information

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Markers

Homology

Clone Names

  • MGC117713

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heparin binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
colocalizes_with extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein eva-1 homolog C
Names
protein FAM176C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199210.2 → NP_001186139.1  protein eva-1 homolog C isoform 1 precursor

    See identical proteins and their annotated locations for NP_001186139.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC134560, AK016443, AK037486, BC100350
    Consensus CDS
    CCDS57038.1
    UniProtKB/Swiss-Prot
    A2RSZ2, P58659, Q497W3, Q9D4L3
    UniProtKB/TrEMBL
    A0A384DV69
    Related
    ENSMUSP00000036695.8, ENSMUST00000037539.15
    Conserved Domains (2) summary
    pfam02140
    Location:75 → 158
    Gal_Lectin; Galactose binding lectin domain
    pfam14851
    Location:300 → 440
    FAM176; FAM176 family

  2. NM_001316760.1 → NP_001303689.1  protein eva-1 homolog C isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC134560, AK016443, AK037486
    Consensus CDS
    CCDS84261.1
    UniProtKB/TrEMBL
    B2RXT2
    Related
    ENSMUST00000232665.2
    Conserved Domains (2) summary
    pfam02140
    Location:81 → 164
    Gal_Lectin; Galactose binding lectin domain
    pfam14851
    Location:205 → 345
    FAM176; FAM176 family

  3. NM_001316761.1 → NP_001303690.1  protein eva-1 homolog C isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC134560, AK016443, AK037486
    Consensus CDS
    CCDS88968.1
    UniProtKB/TrEMBL
    A0A338P750, B2RXT2
    Related
    ENSMUSP00000156225.2, ENSMUST00000231280.2
    Conserved Domains (2) summary
    pfam02140
    Location:69 → 152
    Gal_Lectin; Galactose binding lectin domain
    pfam14851
    Location:193 → 333
    FAM176; FAM176 family

  4. NM_027627.3 → NP_081903.1  protein eva-1 homolog C isoform 2

    See identical proteins and their annotated locations for NP_081903.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC134560, AK037486, BC100350
    Consensus CDS
    CCDS28319.1
    UniProtKB/Swiss-Prot
    P58659
    UniProtKB/TrEMBL
    Q8CAX0
    Related
    ENSMUSP00000097141.4, ENSMUST00000099543.10
    Conserved Domains (2) summary
    pfam02140
    Location:75 → 158
    Gal_Lectin; Galactose binding lectin domain
    pfam14851
    Location:252 → 392
    FAM176; FAM176 family

RNA

  1. NR_133572.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks two alternate exons compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC134560, AK037486
    Related
    ENSMUST00000130868.8

  2. NR_133573.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC134560, AK016443, AK037486
    Related
    ENSMUST00000152223.3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    90623607..90701997
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317131.1 → XP_017172620.1  protein eva-1 homolog C isoform X2

    UniProtKB/TrEMBL
    B2RXT2
    Conserved Domains (2) summary
    pfam02140
    Location:81 → 164
    Gal_Lectin; Galactose binding lectin domain
    pfam14851
    Location:205 → 345
    FAM176; FAM176 family

  2. XM_006523085.5 → XP_006523148.1  protein eva-1 homolog C isoform X1

    UniProtKB/TrEMBL
    A0A384DV69
    Conserved Domains (2) summary
    pfam02140
    Location:75 → 157
    Gal_Lectin; Galactose binding lectin domain
    pfam14851
    Location:299 → 439
    FAM176; FAM176 family

  3. XM_030249282.2 → XP_030105142.1  protein eva-1 homolog C isoform X3

    UniProtKB/TrEMBL
    B2RXT2
    Conserved Domains (1) summary
    pfam14851
    Location:145 → 285
    FAM176; FAM176 family

  4. XM_017317132.1 → XP_017172621.1  protein eva-1 homolog C isoform X2

    UniProtKB/TrEMBL
    B2RXT2
    Conserved Domains (2) summary
    pfam02140
    Location:81 → 164
    Gal_Lectin; Galactose binding lectin domain
    pfam14851
    Location:205 → 345
    FAM176; FAM176 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P58659.2 GenPept UniProtKB/Swiss-Prot:P58659

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