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Clec12b C-type lectin domain family 12, member B [ Mus musculus (house mouse) ]

Gene ID: 71183, updated on 12-May-2024

Summary

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Official Symbol
Clec12bprovided by MGI
Official Full Name
C-type lectin domain family 12, member Bprovided by MGI
Primary source
MGI:MGI:1918433
See related
Ensembl:ENSMUSG00000030158 AllianceGenome:MGI:1918433
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933425B16Rik
Summary
Predicted to enable protein phosphatase binding activity and signaling receptor inhibitor activity. Predicted to be involved in natural killer cell inhibitory signaling pathway; negative regulation of natural killer cell mediated cytotoxicity; and negative regulation of signaling receptor activity. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of protein-containing complex. Predicted to be active in external side of plasma membrane. Orthologous to human CLEC12B (C-type lectin domain family 12 member B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 1.4), lung adult (RPKM 1.3) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Clec12b in Genome Data Viewer
Location:
6 F3; 6 63.28 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (129352476..129404597, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (129375513..129427634, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9103 Neighboring gene C-type lectin domain family 2, member m Neighboring gene STARR-seq mESC enhancer starr_17478 Neighboring gene C-type lectin domain family 12, member a Neighboring gene STARR-seq mESC enhancer starr_17479 Neighboring gene STARR-positive B cell enhancer ABC_E6498 Neighboring gene STARR-positive B cell enhancer ABC_E4872 Neighboring gene C-type lectin domain family 1, member b Neighboring gene C-type lectin domain family 9, member a Neighboring gene STARR-positive B cell enhancer mm9_chr6:129384284-129384585 Neighboring gene C-type lectin domain family 1, member a Neighboring gene STARR-seq mESC enhancer starr_17480 Neighboring gene predicted gene, 45969 Neighboring gene C-type lectin domain family 7, member a Neighboring gene oxidized low density lipoprotein (lectin-like) receptor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CLEC4A and CLEC12B C-type lectin receptors mediate interactions with Pneumocystis cell wall components. Kottom TJ, et al. J Med Microbiol, 2023 Jun. PMID 37294293
  2. Selective expression of a C-type lectin receptor, Clec12b, on skin mast cells. Iijima A, et al. Biochem Biophys Res Commun, 2021 Jul 5. PMID 34020140
  3. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CLEC4A and CLEC12B C-type lectin receptors mediate interactions with Pneumocystis cell wall components.
    Title: CLEC4A and CLEC12B C-type lectin receptors mediate interactions with Pneumocystis cell wall components.
  2. Selective expression of a C-type lectin receptor, Clec12b, on skin mast cells.
    Title: Selective expression of a C-type lectin receptor, Clec12b, on skin mast cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (1)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor regulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in melanocyte proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in natural killer cell inhibitory signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in natural killer cell inhibitory signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of receptor signaling pathway via STAT ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of signaling receptor activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
C-type lectin domain family 12 member B
Names
macrophage antigen h

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204223.1 → NP_001191152.1  C-type lectin domain family 12 member B

    See identical proteins and their annotated locations for NP_001191152.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC138620
    Consensus CDS
    CCDS51922.1
    UniProtKB/Swiss-Prot
    Q149M0, Q9D403
    UniProtKB/TrEMBL
    A0A0R4J0A7
    Related
    ENSMUSP00000107713.4, ENSMUST00000112082.9
    Conserved Domains (1) summary
    cd03593
    Location:142 → 264
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

  2. NM_027709.2 → NP_081985.1  C-type lectin domain family 12 member B

    See identical proteins and their annotated locations for NP_081985.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK016908, AV319772
    Consensus CDS
    CCDS51922.1
    UniProtKB/Swiss-Prot
    Q149M0, Q9D403
    UniProtKB/TrEMBL
    A0A0R4J0A7
    Related
    ENSMUSP00000032261.7, ENSMUST00000032261.9
    Conserved Domains (1) summary
    cd03593
    Location:142 → 264
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    129352476..129404597 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241466.1 → XP_011239768.1  C-type lectin domain family 12 member B isoform X1

    See identical proteins and their annotated locations for XP_011239768.1

    UniProtKB/Swiss-Prot
    Q149M0, Q9D403
    Conserved Domains (1) summary
    cd03593
    Location:145 → 267
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

  2. XM_006506612.2 → XP_006506675.1  C-type lectin domain family 12 member B isoform X2

    See identical proteins and their annotated locations for XP_006506675.1

    UniProtKB/Swiss-Prot
    Q149M0, Q9D403
    UniProtKB/TrEMBL
    A0A0R4J0A7
    Conserved Domains (1) summary
    cd03593
    Location:142 → 264
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q149M0.1 GenPept UniProtKB/Swiss-Prot:Q149M0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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