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CD4 CD4 molecule [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 713807, updated on 17-Aug-2024

Summary

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Official Symbol
CD4provided by VGNC
Official Full Name
CD4 moleculeprovided by VGNC
Primary source
VGNC:VGNC:99912
See related
Ensembl:ENSMMUG00000013202
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See CD4 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
12
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 11 NC_041764.1 (6953431..6986331)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 11 NC_027903.1 (7097437..7129417)

Chromosome 11 - NC_041764.1Genomic Context describing neighboring genes Neighboring gene parathymosin Neighboring gene lymphocyte activating 3 Neighboring gene G protein-coupled receptor 162 Neighboring gene prolyl 3-hydroxylase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sequence and functional properties of African green monkey CD4 silencer. Matsunaga S, et al. Immunol Lett, 2000 Dec 1. PMID 11163866
  2. Nuclear gene trees and the phylogenetic relationships of the mangabeys (Primates: Papionini). Harris EE, et al. Mol Biol Evol, 1998 Jul. PMID 9656488
  3. Position-dependent variegation of a CD4 minigene with targeted expression to mature CD4+ T cells. Boyer O, et al. J Immunol, 1997 Oct 1. PMID 9317137
  4. CD4+ T cells support production of simian immunodeficiency virus Env antibodies that enforce CD4-dependent entry and shape tropism in vivo. Francella N, et al. J Virol, 2013 Sep. PMID 23824793, Free PMC Article
  5. Identification of HIV-1 Envelope Mutations that Enhance Entry Using Macaque CD4 and CCR5. Roop JI, et al. Viruses, 2020 Feb 21. PMID 32098152, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of HIV-1 Envelope Mutations that Enhance Entry Using Macaque CD4 and CCR5.
    Title: Identification of HIV-1 Envelope Mutations that Enhance Entry Using Macaque CD4 and CCR5.
  2. The absence of CD4 T cells results in failure to produce antibodies that neutralize CD4-independent SIV Envs and CD4-pretriggered control SIV Envs.
    Title: CD4+ T cells support production of simian immunodeficiency virus Env antibodies that enforce CD4-dependent entry and shape tropism in vivo.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables MHC class II protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables coreceptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in T cell activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in interleukin-15-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
T-cell surface glycoprotein CD4
Names
CD4 antigen
T-cell surface antigen T4/Leu-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042662.1 → NP_001036127.1  T-cell surface glycoprotein CD4 precursor

    See identical proteins and their annotated locations for NP_001036127.1

    Status: PROVISIONAL

    Source sequence(s)
    M31134
    UniProtKB/Swiss-Prot
    P16003, Q29617
    Conserved Domains (5) summary
    smart00410
    Location:129 → 201
    IG_like; Immunoglobulin like
    pfam05790
    Location:317 → 389
    C2-set; Immunoglobulin C2-set domain
    pfam09191
    Location:208 → 316
    CD4-extracel; CD4, extracellular
    pfam12104
    Location:426 → 453
    Tcell_CD4_C; T cell CD4 receptor C terminal region
    cl11960
    Location:28 → 109
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041764.1 Reference Mmul_10 Primary Assembly

    Range
    6953431..6986331
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015150817.2 → XP_015006303.2  T-cell surface glycoprotein CD4 isoform X1

    UniProtKB/TrEMBL
    A0A2Z5GBT8, F6XGD3, H9G1S6
    Related
    ENSMMUP00000017342.4, ENSMMUT00000018518.4
    Conserved Domains (4) summary
    pfam05790
    Location:317 → 389
    C2-set; Immunoglobulin C2-set domain
    pfam12104
    Location:426 → 453
    Tcell_CD4_C; T cell CD4 receptor C terminal region
    pfam09191
    Location:208 → 316
    CD4-extracel; CD4, extracellular
    cl11960
    Location:28 → 109
    Ig; Immunoglobulin domain

  2. XM_015150818.2 → XP_015006304.2  T-cell surface glycoprotein CD4 isoform X1

    UniProtKB/TrEMBL
    A0A2Z5GBT8, F6XGD3, H9G1S6
    Related
    ENSMMUP00000069370.1, ENSMMUT00000104352.1
    Conserved Domains (4) summary
    pfam05790
    Location:317 → 389
    C2-set; Immunoglobulin C2-set domain
    pfam12104
    Location:426 → 453
    Tcell_CD4_C; T cell CD4 receptor C terminal region
    pfam09191
    Location:208 → 316
    CD4-extracel; CD4, extracellular
    cl11960
    Location:28 → 109
    Ig; Immunoglobulin domain

  3. XM_028828990.1 → XP_028684823.1  T-cell surface glycoprotein CD4 isoform X1

    UniProtKB/TrEMBL
    A0A2Z5GBT8, F6XGD3, H9G1S6
    Conserved Domains (4) summary
    pfam05790
    Location:317 → 389
    C2-set; Immunoglobulin C2-set domain
    pfam12104
    Location:426 → 453
    Tcell_CD4_C; T cell CD4 receptor C terminal region
    pfam09191
    Location:208 → 316
    CD4-extracel; CD4, extracellular
    cl11960
    Location:28 → 109
    Ig; Immunoglobulin domain

  4. XM_015150821.2 → XP_015006307.2  T-cell surface glycoprotein CD4 isoform X3

    Conserved Domains (3) summary
    pfam05790
    Location:44 → 116
    C2-set; Immunoglobulin C2-set domain
    pfam12104
    Location:153 → 180
    Tcell_CD4_C; T cell CD4 receptor C terminal region
    cl11960
    Location:1 → 43
    Ig; Immunoglobulin domain

  5. XM_015150820.2 → XP_015006306.2  T-cell surface glycoprotein CD4 isoform X2

    UniProtKB/TrEMBL
    A0A5F8A870
    Related
    ENSMMUP00000074062.1, ENSMMUT00000087657.1
    Conserved Domains (3) summary
    pfam05790
    Location:138 → 210
    C2-set; Immunoglobulin C2-set domain
    pfam12104
    Location:247 → 274
    Tcell_CD4_C; T cell CD4 receptor C terminal region
    pfam09191
    Location:29 → 137
    CD4-extracel; CD4, extracellular
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P16003.2 GenPept UniProtKB/Swiss-Prot:P16003

Gene LinkOut

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