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Kctd6 potassium channel tetramerisation domain containing 6 [ Mus musculus (house mouse) ]

Gene ID: 71393, updated on 17-Aug-2024

Summary

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Official Symbol
Kctd6provided by MGI
Official Full Name
potassium channel tetramerisation domain containing 6provided by MGI
Primary source
MGI:MGI:1918643
See related
Ensembl:ENSMUSG00000021752 AllianceGenome:MGI:1918643
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5430433B02Rik
Summary
Predicted to enable ankyrin binding activity; cullin family protein binding activity; and identical protein binding activity. Predicted to be involved in negative regulation of smoothened signaling pathway and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within regulation of growth. Predicted to be located in cytoplasm. Is expressed in forebrain; ganglia; and vibrissa. Orthologous to human KCTD6 (potassium channel tetramerization domain containing 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 3.8), frontal lobe adult (RPKM 3.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 A1; 14 4.76 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (14246186..14255692, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (8214081..8223587)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 107, member A Neighboring gene STARR-seq mESC enhancer starr_35868 Neighboring gene acyl-Coenzyme A oxidase 2, branched chain Neighboring gene STARR-seq mESC enhancer starr_35867 Neighboring gene predicted gene, 53823 Neighboring gene STARR-seq mESC enhancer starr_35863 Neighboring gene pyruvate dehydrogenase (lipoamide) beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover. Lange S, et al. Mol Biol Cell, 2012 Jul. PMID 22573887, Free PMC Article
  2. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ankyrin binding ISO
Inferred from Sequence Orthology
more info
  
enables cullin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cullin family protein binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
BTB/POZ domain-containing protein KCTD6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305936.1 → NP_001292865.1  BTB/POZ domain-containing protein KCTD6

    See identical proteins and their annotated locations for NP_001292865.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
    Source sequence(s)
    AK082924, AK159067, CJ248971
    Consensus CDS
    CCDS26812.1
    UniProtKB/Swiss-Prot
    Q3TXX1, Q8BNL5
    UniProtKB/TrEMBL
    A2RS47
    Related
    ENSMUSP00000129059.2, ENSMUST00000170111.3
    Conserved Domains (1) summary
    cl38908
    Location:10 → 113
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

  2. NM_001305937.1 → NP_001292866.1  BTB/POZ domain-containing protein KCTD6

    See identical proteins and their annotated locations for NP_001292866.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AK082924, BB625950, CJ248971
    Consensus CDS
    CCDS26812.1
    UniProtKB/Swiss-Prot
    Q3TXX1, Q8BNL5
    UniProtKB/TrEMBL
    A2RS47
    Conserved Domains (1) summary
    cl38908
    Location:10 → 113
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

  3. NM_027782.3 → NP_082058.1  BTB/POZ domain-containing protein KCTD6

    See identical proteins and their annotated locations for NP_082058.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AK082924, CJ248971, CX239507
    Consensus CDS
    CCDS26812.1
    UniProtKB/Swiss-Prot
    Q3TXX1, Q8BNL5
    UniProtKB/TrEMBL
    A2RS47
    Related
    ENSMUSP00000022272.7, ENSMUST00000022272.14
    Conserved Domains (1) summary
    cl38908
    Location:10 → 113
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    14246186..14255692 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158852.1 → XP_036014745.1  BTB/POZ domain-containing protein KCTD6 isoform X1

    UniProtKB/Swiss-Prot
    Q3TXX1, Q8BNL5
    UniProtKB/TrEMBL
    A2RS47
    Conserved Domains (1) summary
    cl38908
    Location:10 → 113
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

  2. XM_006518105.3 → XP_006518168.1  BTB/POZ domain-containing protein KCTD6 isoform X1

    See identical proteins and their annotated locations for XP_006518168.1

    UniProtKB/Swiss-Prot
    Q3TXX1, Q8BNL5
    UniProtKB/TrEMBL
    A2RS47
    Conserved Domains (1) summary
    cl38908
    Location:10 → 113
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BNL5.1 GenPept UniProtKB/Swiss-Prot:Q8BNL5

Gene LinkOut

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