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Mamdc2 MAM domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 71738, updated on 17-Aug-2024

Summary

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Official Symbol
Mamdc2provided by MGI
Official Full Name
MAM domain containing 2provided by MGI
Primary source
MGI:MGI:1918988
See related
Ensembl:ENSMUSG00000033207 AllianceGenome:MGI:1918988
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mamcan; 1200015L10Rik
Summary
Enables glycosaminoglycan binding activity. Acts upstream of or within peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan. Located in interstitial matrix. Is expressed in embryo and rib. Orthologous to human MAMDC2 (MAM domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 30.1), subcutaneous fat pad adult (RPKM 9.7) and 4 other tissues See more
Orthologs
human all
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Genomic context

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See Mamdc2 in Genome Data Viewer
Location:
19 B; 19 18.22 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (23279973..23425855, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (23302609..23448497, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene structural maintenance of chromosomes 5 Neighboring gene STARR-positive B cell enhancer mm9_chr19:23348377-23348678 Neighboring gene predicted gene, 33950 Neighboring gene STARR-seq mESC enhancer starr_45773 Neighboring gene predicted gene, 24263 Neighboring gene predicted gene, 41821 Neighboring gene STARR-seq mESC enhancer starr_45774 Neighboring gene STARR-seq mESC enhancer starr_45776 Neighboring gene predicted gene, 34012 Neighboring gene STARR-seq mESC enhancer starr_45777 Neighboring gene cilia and flagella associated protein 95 Neighboring gene 40S ribosomal protein S7 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of Modifier Genes in a Mouse Model of Gaucher Disease. Klein AD, et al. Cell Rep, 2016 Sep 6. PMID 27568557
  2. Osteoblast-specific expression of Panx3 is dispensable for postnatal bone remodeling. Yorgan TA, et al. Bone, 2019 Oct. PMID 31202927
  3. Transcriptome-based systematic identification of extracellular matrix proteins. Manabe R, et al. Proc Natl Acad Sci U S A, 2008 Sep 2. PMID 18757743, Free PMC Article
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glycosaminoglycan binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in interstitial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
MAM domain-containing protein 2
Names
MAM domain-containing proteoglycan

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174857.3 → NP_777282.1  MAM domain-containing protein 2 precursor

    See identical proteins and their annotated locations for NP_777282.1

    Status: PROVISIONAL

    Source sequence(s)
    AC124557, AC131118, AC144941
    Consensus CDS
    CCDS29707.1
    UniProtKB/TrEMBL
    A0A0R4J0J7, Q3U4I9
    Related
    ENSMUSP00000045432.7, ENSMUST00000036069.8
    Conserved Domains (2) summary
    cd06263
    Location:509 → 664
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    pfam00629
    Location:509 → 666
    MAM; MAM domain, meprin/A5/mu

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    23279973..23425855 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161694.1 → XP_036017587.1  MAM domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    Q3U4I9
    Conserved Domains (2) summary
    cd06263
    Location:512 → 667
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    pfam00629
    Location:173 → 330
    MAM; MAM domain, meprin/A5/mu

RNA

  1. XR_004940174.1 RNA Sequence

  2. XR_003952820.2 RNA Sequence

    Related
    ENSMUST00000236349.2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CG85.1 GenPept UniProtKB/Swiss-Prot:Q8CG85

Gene LinkOut

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