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Nup58 nucleoporin 58 [ Mus musculus (house mouse) ]

Gene ID: 71844, updated on 18-Nov-2024

Summary

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Official Symbol
Nup58provided by MGI
Official Full Name
nucleoporin 58provided by MGI
Primary source
MGI:MGI:1919094
See related
Ensembl:ENSMUSG00000114797 AllianceGenome:MGI:1919094
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nupl1; mKIAA0410; 1700017F11Rik
Summary
Predicted to enable identical protein binding activity and nuclear localization sequence binding activity. Predicted to be a structural constituent of nuclear pore. Predicted to be involved in nucleocytoplasmic transport and regulation of protein import into nucleus. Predicted to be located in nuclear envelope. Predicted to be part of nuclear pore. Is expressed in testis. Orthologous to human NUP58 (nucleoporin 58). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 28.8), CNS E11.5 (RPKM 13.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Nup58 in Genome Data Viewer
Location:
14 D1; 14 31.62 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (60442733..60488951, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (60205284..60251479, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33582 Neighboring gene predicted gene, 57492 Neighboring gene STARR-seq mESC enhancer starr_36855 Neighboring gene microRNA 719 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:60870359-60870542 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:60883833-60884016 Neighboring gene myotubularin related protein 6 Neighboring gene predicted gene, 34874 Neighboring gene STARR-seq mESC enhancer starr_36856 Neighboring gene STARR-seq mESC enhancer starr_36857 Neighboring gene APC membrane recruitment 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Gene- and Species-Specific Hox mRNA Translation by Ribosome Expansion Segments. Leppek K, et al. Mol Cell, 2020 Dec 17. PMID 33202249, Free PMC Article
  2. Peering through the pore: nuclear pore complex structure, assembly, and function. Suntharalingam M, et al. Dev Cell, 2003 Jun. PMID 12791264
  3. Bioinformatics and cellular signaling. Papin J, et al. Curr Opin Biotechnol, 2004 Feb. PMID 15102471
  4. Comprehensive Proteomic Analysis of PGC7-Interacting Proteins. Liu H, et al. J Proteome Res, 2017 Sep 1. PMID 28712289
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear localization sequence binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear localization sequence binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of nuclear pore IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of nuclear pore ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleocytoplasmic transport ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleocytoplasmic transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein import into nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear pore NAS
Non-traceable Author Statement
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nucleoporin p58/p45
Names
58 kDa nucleoporin
nucleoporin like 1
nucleoporin-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362439.1 → NP_001349368.1  nucleoporin p58/p45 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC131687, AC166113, AK006062, AK086412
    Consensus CDS
    CCDS88679.1
    UniProtKB/TrEMBL
    Q3UZQ6
    Related
    ENSMUSP00000153625.2, ENSMUST00000225111.2
    Conserved Domains (1) summary
    cl25599
    Location:3 → 537
    Nucleoporin_FG2; Nucleoporin FG repeated region

  2. NM_001362440.1 → NP_001349369.1  nucleoporin p58/p45 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC131687, AC166113, AK006062, AK078279
    Consensus CDS
    CCDS88680.1
    UniProtKB/TrEMBL
    Q3UZQ6
    Related
    ENSMUSP00000153117.2, ENSMUST00000225311.2
    Conserved Domains (1) summary
    cl25599
    Location:3 → 541
    Nucleoporin_FG2; Nucleoporin FG repeated region

  3. NM_170591.2 → NP_733479.1  nucleoporin p58/p45 isoform 1

    See identical proteins and their annotated locations for NP_733479.1

    Status: VALIDATED

    Source sequence(s)
    AC166113, AK040206, AK139895, AK146477, CJ220943, EH096615
    Consensus CDS
    CCDS27175.1
    UniProtKB/Swiss-Prot
    Q3UJF4, Q8BUA7, Q8BVG7, Q8C0W3, Q8R332
    UniProtKB/TrEMBL
    Q3UZQ6
    Related
    ENSMUSP00000038716.7, ENSMUST00000041905.8
    Conserved Domains (2) summary
    pfam02321
    Location:278 → 424
    OEP; Outer membrane efflux protein
    pfam15967
    Location:22 → 587
    Nucleoporin_FG2; Nucleoporin FG repeated region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    60442733..60488951 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158853.1 → XP_036014746.1  nucleoporin p58/p45 isoform X1

    UniProtKB/TrEMBL
    Q3UZQ6
    Conserved Domains (1) summary
    pfam15967
    Location:2 → 531
    Nucleoporin_FG2; Nucleoporin FG repeated region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R332.1 GenPept UniProtKB/Swiss-Prot:Q8R332

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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