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Gpr160 G protein-coupled receptor 160 [ Mus musculus (house mouse) ]

Gene ID: 71862, updated on 9-Dec-2024

Summary

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Official Symbol
Gpr160provided by MGI
Official Full Name
G protein-coupled receptor 160provided by MGI
Primary source
MGI:MGI:1919112
See related
Ensembl:ENSMUSG00000037661 AllianceGenome:MGI:1919112
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GPCR150; 1700025D19Rik
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in trigeminal ganglion. Orthologous to human GPR160 (G protein-coupled receptor 160). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in testis adult (RPKM 54.6), large intestine adult (RPKM 20.2) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Gpr160 in Genome Data Viewer
Location:
3 A3; 3 14.33 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (30909908..30951344)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (30855759..30897194)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene SEC62 homolog, preprotein translocation Neighboring gene predicted gene, 42198 Neighboring gene predicted gene, 42199 Neighboring gene STARR-seq mESC enhancer starr_07303 Neighboring gene polyhomeotic 3 Neighboring gene STARR-positive B cell enhancer ABC_E4537 Neighboring gene predicted gene 2979

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. GPR160 regulates the self-renewal and pluripotency of mouse embryonic stem cells via JAK1/STAT3 signaling pathway. Fan S, et al. J Genet Genomics, 2024 Oct. PMID 38750952
  2. Behavioral characterization of G-protein-coupled receptor 160 knockout mice. Schafer RM, et al. Pain, 2024 Jun 1. PMID 38198232,
  3. G protein-coupled receptor GPR160 is associated with apoptosis and cell cycle arrest of prostate cancer cells. Zhou C, et al. Oncotarget, 2016 Mar 15. PMID 26871479, Free PMC Article
  4. G protein-coupled receptor160 regulates mycobacteria entry into macrophages by activating ERK. Yang H, et al. Cell Signal, 2016 Sep. PMID 27259691
  5. Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice. Ding S, et al. Cell, 2005 Aug 12. PMID 16096065

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GPR160 regulates the self-renewal and pluripotency of mouse embryonic stem cells via JAK1/STAT3 signaling pathway.
    Title: GPR160 regulates the self-renewal and pluripotency of mouse embryonic stem cells via JAK1/STAT3 signaling pathway.
  2. Behavioral characterization of G-protein-coupled receptor 160 knockout mice.
    Title: Behavioral characterization of G-protein-coupled receptor 160 knockout mice.
  3. these findings suggest an important role of GPR160 in regulating the entry of BCG into macrophages by targeting the ERK signaling pathway.
    Title: G protein-coupled receptor160 regulates mycobacteria entry into macrophages by activating ERK.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Gene trapped (2) 
  • Targeted (1) 
  • Transposon induced (1)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
probable G-protein coupled receptor 160

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134385.2 → NP_001127857.1  probable G-protein coupled receptor 160

    See identical proteins and their annotated locations for NP_001127857.1

    Status: VALIDATED

    Source sequence(s)
    AC111093, AC158135
    Consensus CDS
    CCDS50883.1
    UniProtKB/Swiss-Prot
    Q3U3F9, Q9D9Y9
    UniProtKB/TrEMBL
    Q14AX2
    Related
    ENSMUSP00000103893.2, ENSMUST00000108258.8

  2. NM_001134386.2 → NP_001127858.1  probable G-protein coupled receptor 160

    See identical proteins and their annotated locations for NP_001127858.1

    Status: VALIDATED

    Source sequence(s)
    AC111093, BY207079
    Consensus CDS
    CCDS50883.1
    UniProtKB/Swiss-Prot
    Q3U3F9, Q9D9Y9
    UniProtKB/TrEMBL
    Q14AX2
    Related
    ENSMUSP00000128666.2, ENSMUST00000166278.7

  3. NM_001286994.1 → NP_001273923.1  probable G-protein coupled receptor 160

    See identical proteins and their annotated locations for NP_001273923.1

    Status: VALIDATED

    Source sequence(s)
    AC111093, AC158135
    Consensus CDS
    CCDS50883.1
    UniProtKB/Swiss-Prot
    Q3U3F9, Q9D9Y9
    UniProtKB/TrEMBL
    Q14AX2
    Related
    ENSMUSP00000103896.2, ENSMUST00000108261.8

  4. NM_001286995.1 → NP_001273924.1  probable G-protein coupled receptor 160

    See identical proteins and their annotated locations for NP_001273924.1

    Status: VALIDATED

    Source sequence(s)
    AC111093, AC158135
    Consensus CDS
    CCDS50883.1
    UniProtKB/Swiss-Prot
    Q3U3F9, Q9D9Y9
    UniProtKB/TrEMBL
    Q14AX2
    Related
    ENSMUSP00000103894.2, ENSMUST00000108259.8

  5. NM_001286996.1 → NP_001273925.1  probable G-protein coupled receptor 160

    See identical proteins and their annotated locations for NP_001273925.1

    Status: VALIDATED

    Source sequence(s)
    AC111093, AC158135, BY208743
    Consensus CDS
    CCDS50883.1
    UniProtKB/Swiss-Prot
    Q3U3F9, Q9D9Y9
    UniProtKB/TrEMBL
    Q14AX2

  6. NM_001357144.1 → NP_001344073.1  probable G-protein coupled receptor 160

    Status: VALIDATED

    Source sequence(s)
    AC111093, AC158135
    Consensus CDS
    CCDS50883.1
    UniProtKB/Swiss-Prot
    Q3U3F9, Q9D9Y9
    UniProtKB/TrEMBL
    Q14AX2

  7. NM_027965.2 → NP_082241.1  probable G-protein coupled receptor 160

    See identical proteins and their annotated locations for NP_082241.1

    Status: VALIDATED

    Source sequence(s)
    AC111093, AC158135, AK006330
    Consensus CDS
    CCDS50883.1
    UniProtKB/Swiss-Prot
    Q3U3F9, Q9D9Y9
    UniProtKB/TrEMBL
    Q14AX2
    Related
    ENSMUSP00000045165.7, ENSMUST00000046748.13

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    30909908..30951344
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319737.3 → XP_017175226.1  probable G-protein coupled receptor 160 isoform X1

    UniProtKB/Swiss-Prot
    Q3U3F9, Q9D9Y9
    UniProtKB/TrEMBL
    Q14AX2

  2. XM_030252832.2 → XP_030108692.1  probable G-protein coupled receptor 160 isoform X1

    UniProtKB/Swiss-Prot
    Q3U3F9, Q9D9Y9
    UniProtKB/TrEMBL
    Q14AX2

  3. XM_030252830.2 → XP_030108690.1  probable G-protein coupled receptor 160 isoform X1

    UniProtKB/Swiss-Prot
    Q3U3F9, Q9D9Y9
    UniProtKB/TrEMBL
    Q14AX2

  4. XM_017319735.3 → XP_017175224.1  probable G-protein coupled receptor 160 isoform X1

    UniProtKB/Swiss-Prot
    Q3U3F9, Q9D9Y9
    UniProtKB/TrEMBL
    Q14AX2

  5. XM_006535539.4 → XP_006535602.1  probable G-protein coupled receptor 160 isoform X1

    See identical proteins and their annotated locations for XP_006535602.1

    UniProtKB/Swiss-Prot
    Q3U3F9, Q9D9Y9
    UniProtKB/TrEMBL
    Q14AX2

  6. XM_017319734.3 → XP_017175223.1  probable G-protein coupled receptor 160 isoform X1

    UniProtKB/Swiss-Prot
    Q3U3F9, Q9D9Y9
    UniProtKB/TrEMBL
    Q14AX2

  7. XM_030252831.2 → XP_030108691.1  probable G-protein coupled receptor 160 isoform X1

    UniProtKB/Swiss-Prot
    Q3U3F9, Q9D9Y9
    UniProtKB/TrEMBL
    Q14AX2

  8. XM_036163339.1 → XP_036019232.1  probable G-protein coupled receptor 160 isoform X1

    UniProtKB/Swiss-Prot
    Q3U3F9, Q9D9Y9
    UniProtKB/TrEMBL
    Q14AX2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U3F9.1 GenPept UniProtKB/Swiss-Prot:Q3U3F9

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