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Aopep aminopeptidase O [ Mus musculus (house mouse) ]

Gene ID: 72061, updated on 9-Dec-2024

Summary

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Official Symbol
Aopepprovided by MGI
Official Full Name
aminopeptidase Oprovided by MGI
Primary source
MGI:MGI:1919311
See related
Ensembl:ENSMUSG00000021458 AllianceGenome:MGI:1919311
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ApO; AP-O; mir-23b; mir-27b; mir-24-1; 2010111I01Rik; 2300006M17Rik
Summary
Predicted to enable metalloaminopeptidase activity and zinc ion binding activity. Predicted to be involved in proteolysis. Located in nucleolus. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut gland; and liver and biliary system. Human ortholog(s) of this gene implicated in dystonia 31. Orthologous to human AOPEP (aminopeptidase O (putative)). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 14.3), limb E14.5 (RPKM 9.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Aopep in Genome Data Viewer
Location:
13 B3; 13 32.8 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (63112707..63473910)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (62964893..63326096)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_34785 Neighboring gene STARR-seq mESC enhancer starr_34786 Neighboring gene predicted gene, 38679 Neighboring gene fructose bisphosphatase 1 Neighboring gene predicted gene, 40981 Neighboring gene STARR-positive B cell enhancer ABC_E7247 Neighboring gene tubulin, beta 2a, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_34787 Neighboring gene predicted gene, 46422 Neighboring gene predicted gene, 30409 Neighboring gene STARR-seq mESC enhancer starr_34791 Neighboring gene STARR-seq mESC enhancer starr_34792 Neighboring gene microRNA 3074-1 Neighboring gene STARR-positive B cell enhancer mm9_chr13:63433953-63434254 Neighboring gene predicted gene, 16907 Neighboring gene STARR-seq mESC enhancer starr_34797 Neighboring gene microRNA 24-1 Neighboring gene microRNA 23b Neighboring gene microRNA 27b Neighboring gene Fanconi anemia, complementation group C Neighboring gene STARR-seq mESC enhancer starr_34799 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:63532981-63533164 Neighboring gene STARR-seq mESC enhancer starr_34801 Neighboring gene STARR-seq mESC enhancer starr_34802 Neighboring gene Ptch1 Hedgehog-responsive enhancers Neighboring gene patched 1 Neighboring gene STARR-seq mESC enhancer starr_34806 Neighboring gene predicted gene, 30655

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. miR-23b Suppresses Leukocyte Migration and Pathogenesis of Experimental Autoimmune Encephalomyelitis by Targeting CCL7. Zhang Y, et al. Mol Ther, 2018 Feb 7. PMID 29275848, Free PMC Article
  2. MicroRNA-27b Regulates Mitochondria Biogenesis in Myocytes. Shen L, et al. PLoS One, 2016. PMID 26849429, Free PMC Article
  3. Glucocorticoids transcriptionally regulate miR-27b expression promoting body fat accumulation via suppressing the browning of white adipose tissue. Kong X, et al. Diabetes, 2015 Feb. PMID 25187367, Free PMC Article
  4. Loss of miR-23b/27b/24-1 Cluster Impairs Glucose Tolerance via Glycolysis Pathway in Mice. Jiang YH, et al. Int J Mol Sci, 2021 Jan 7. PMID 33430468, Free PMC Article
  5. miRNA-27b modulates endothelial cell angiogenesis by directly targeting Naa15 in atherogenesis. Qun L, et al. Atherosclerosis, 2016 Nov. PMID 27755984

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of miR-23b/27b/24-1 Cluster Impairs Glucose Tolerance via Glycolysis Pathway in Mice.
    Title: Loss of miR-23b/27b/24-1 Cluster Impairs Glucose Tolerance via Glycolysis Pathway in Mice.
  2. our results characterize a novel aspect of miR-23b function in leukocyte migration, and they identify miR-23b as a potential therapeutic target in the amelioration of MS and likely other autoimmune diseases.
    Title: miR-23b Suppresses Leukocyte Migration and Pathogenesis of Experimental Autoimmune Encephalomyelitis by Targeting CCL7.
  3. decreased miRNA-27b regulates the activity of the CCL20/CCR6 axis by targeting Naa15, and promotes plaque stability in atherosclerosis
    Title: miRNA-27b modulates endothelial cell angiogenesis by directly targeting Naa15 in atherogenesis.
  4. MiRNA-27b regulates mitochondria biogenesis in myocytes by down-regulation of Foxj3 during myocyte differentiation.
    Title: MicroRNA-27b Regulates Mitochondria Biogenesis in Myocytes.
  5. These results indicate that miR-27b functions as a central target of glucocorticoids and as an upstream regulator of Prdm16.
    Title: Glucocorticoids transcriptionally regulate miR-27b expression promoting body fat accumulation via suppressing the browning of white adipose tissue.
  6. Alternative splicing predictably produces protein products with or without the catalytic domain and/or a nucleolar localisation signal and represents mechanism in regulating activity of APO.
    Title: Aminopeptidase O contains a functional nucleolar localization signal and is implicated in vascular biology.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1)  1 citation
  • Targeted (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metalloaminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
aminopeptidase O

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289924.1 → NP_001276853.1  aminopeptidase O

    See identical proteins and their annotated locations for NP_001276853.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC154382, AK044477, CT009757
    Consensus CDS
    CCDS36699.1
    UniProtKB/Swiss-Prot
    Q3UQZ7, Q6P0W6, Q6P394, Q8BHX5, Q8BXQ6
    UniProtKB/TrEMBL
    A0A1Y7VJQ6
    Related
    ENSMUSP00000152528.2, ENSMUST00000220863.2
    Conserved Domains (2) summary
    pfam09127
    Location:710 → 822
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    cl14813
    Location:244 → 641
    GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

  2. NM_001289926.1 → NP_001276855.1  aminopeptidase O

    See identical proteins and their annotated locations for NP_001276855.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate segment in the 3' UTR. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK044477, AK141931, BX520155, CT009757
    Consensus CDS
    CCDS36699.1
    UniProtKB/Swiss-Prot
    Q3UQZ7, Q6P0W6, Q6P394, Q8BHX5, Q8BXQ6
    UniProtKB/TrEMBL
    A0A1Y7VJQ6
    Related
    ENSMUSP00000089148.5, ENSMUST00000091560.11
    Conserved Domains (2) summary
    pfam09127
    Location:710 → 822
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    cl14813
    Location:244 → 641
    GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

RNA

  1. NR_110520.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' structure compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    CT009757

  2. NR_110521.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate 3' and 5' structure compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC130827, AK076298, CT009757
    Related
    ENSMUST00000159152.3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    63112707..63473910
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_028079.2: Suppressed sequence

    Description
    NM_028079.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BXQ6.3 GenPept UniProtKB/Swiss-Prot:Q8BXQ6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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