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Ces2g carboxylesterase 2G [ Mus musculus (house mouse) ]

Gene ID: 72361, updated on 9-Aug-2024

Summary

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Official Symbol
Ces2gprovided by MGI
Official Full Name
carboxylesterase 2Gprovided by MGI
Primary source
MGI:MGI:1919611
See related
Ensembl:ENSMUSG00000031877 AllianceGenome:MGI:1919611
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ces2l; 2210023G05Rik
Summary
Predicted to enable carboxylic ester hydrolase activity. Predicted to be involved in prostaglandin metabolic process. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in several structures, including central nervous system; foregut; liver; respiratory system; and sensory organ. Orthologous to human CES2 (carboxylesterase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in stomach adult (RPKM 17.0), duodenum adult (RPKM 16.6) and 17 other tissues See more
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Genomic context

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See Ces2g in Genome Data Viewer
Location:
8 D3; 8 53.04 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (105688350..105696169)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (104961596..104969537)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene carboxylesterase 2E Neighboring gene carboxylesterase 2F Neighboring gene STARR-seq mESC enhancer starr_22518 Neighboring gene carboxylesterase 2E pseudogene Neighboring gene carboxylesterase 2H

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Lipopolysaccharide suppresses carboxylesterase 2g activity and 2-arachidonoylglycerol hydrolysis: A possible mechanism to regulate inflammation. Szafran B, et al. Prostaglandins Other Lipid Mediat, 2015 Sep. PMID 26403860, Free PMC Article
  2. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Holmes RS, et al. Mamm Genome, 2010 Oct. PMID 20931200, Free PMC Article
  3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxylesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables carboxylic ester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in prostaglandin metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
carboxylesterase 2-like
NP_932116.2
XP_006531455.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_197999.2 → NP_932116.2  carboxylesterase 2-like precursor

    Status: VALIDATED

    Source sequence(s)
    AC166833
    Consensus CDS
    CCDS22589.1
    UniProtKB/TrEMBL
    E9PV38, Q8R097
    Related
    ENSMUSP00000049315.8, ENSMUST00000043183.8
    Conserved Domains (2) summary
    COG0657
    Location:72 → 337
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:31 → 539
    COesterase; Carboxylesterase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    105688350..105696169
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531392.1 → XP_006531455.1  carboxylesterase 2-like isoform X1

    Conserved Domains (1) summary
    cl21494
    Location:2 → 256
    Abhydrolase; alpha/beta hydrolases
Nucleotide Protein Strain
Heading Accession and Version

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