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Cnfn cornifelin [ Mus musculus (house mouse) ]

Gene ID: 72383, updated on 18-Sep-2024

Summary

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Official Symbol
Cnfnprovided by MGI
Official Full Name
cornifelinprovided by MGI
Primary source
MGI:MGI:1919633
See related
Ensembl:ENSMUSG00000063651 AllianceGenome:MGI:1919633
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2210418J09Rik
Summary
Predicted to act upstream of or within keratinization. Predicted to be located in cytoplasm. Predicted to be active in cornified envelope. Is expressed in external naris. Orthologous to human CNFN (cornifelin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward stomach adult (RPKM 1304.1) See more
Orthologs
human all
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Genomic context

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See Cnfn in Genome Data Viewer
Location:
7 A3; 7 13.78 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (25067041..25069149, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (25367616..25369724, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 145 Neighboring gene multiple EGF-like-domains 8 Neighboring gene RIKEN cDNA 4732471J01 gene Neighboring gene STARR-positive B cell enhancer ABC_E2227 Neighboring gene STARR-positive B cell enhancer ABC_E11345 Neighboring gene lipase, hormone sensitive Neighboring gene C-X-C motif chemokine ligand 17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification and characterization of a novel component of the cornified envelope, cornifelin. Michibata H, et al. Biochem Biophys Res Commun, 2004 Jun 11. PMID 15147942
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in keratinization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cornified envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cornified envelope ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cornifelin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081375.1 → NP_001074844.1  cornifelin isoform 2

    See identical proteins and their annotated locations for NP_001074844.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' coding region and uses a downstream start codon, compared to variant 1. It encodes isoform 2 which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC156992
    Consensus CDS
    CCDS39838.1
    UniProtKB/Swiss-Prot
    Q6PCW6
    Related
    ENSMUSP00000075625.4, ENSMUST00000076276.5
    Conserved Domains (1) summary
    TIGR01571
    Location:21 → 109
    A_thal_Cys_rich; uncharacterized Cys-rich domain

  2. NM_028219.1 → NP_082495.1  cornifelin isoform 1

    See identical proteins and their annotated locations for NP_082495.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC156992
    Consensus CDS
    CCDS52149.1
    UniProtKB/TrEMBL
    G3UWC9
    Related
    ENSMUSP00000130957.2, ENSMUST00000167591.8
    Conserved Domains (1) summary
    TIGR01571
    Location:34 → 122
    A_thal_Cys_rich; uncharacterized Cys-rich domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    25067041..25069149 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PCW6.1 GenPept UniProtKB/Swiss-Prot:Q6PCW6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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