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Cdkn3 cyclin dependent kinase inhibitor 3 [ Mus musculus (house mouse) ]

Gene ID: 72391, updated on 9-Aug-2024

Summary

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Official Symbol
Cdkn3provided by MGI
Official Full Name
cyclin dependent kinase inhibitor 3provided by MGI
Primary source
MGI:MGI:1919641
See related
Ensembl:ENSMUSG00000037628 AllianceGenome:MGI:1919641
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KAP; 2410006H10Rik
Summary
Predicted to enable protein serine/threonine phosphatase activity and protein tyrosine phosphatase activity. Predicted to be involved in dephosphorylation. Predicted to act upstream of or within cellular response to DNA damage stimulus and regulation of cell cycle. Predicted to be located in cytosol and perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Is expressed in axial skeleton; cerebral cortex; cranium; hindlimb long bone; and pelvic girdle skeleton. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human CDKN3 (cyclin dependent kinase inhibitor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 55.4), liver E14 (RPKM 19.2) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Cdkn3 in Genome Data Viewer
Location:
14 24.28 cM; 14 C1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (46997912..47008987)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (46760461..46771530)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933425B07 gene Neighboring gene predicted gene, 41146 Neighboring gene RIKEN cDNA D330046F09 gene Neighboring gene STARR-seq mESC enhancer starr_36562 Neighboring gene STARR-seq mESC enhancer starr_36563 Neighboring gene STARR-positive B cell enhancer ABC_E752 Neighboring gene cornichon family AMPA receptor auxiliary protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E7306 Neighboring gene glia maturation factor, beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cyclin-dependent kinase inhibitor 3 (CDKN3) plays a critical role in prostate cancer via regulating cell cycle and DNA replication signaling. Yu C, et al. Biomed Pharmacother, 2017 Dec. PMID 29196103
  2. The cell cycle associated protein, HTm4, is expressed in differentiating cells of the hematopoietic and central nervous system in mice. Kutok JL, et al. J Mol Histol, 2005 Feb. PMID 15704002
  3. Long non-coding RNA NEAT1 inhibits oxidative stress-induced vascular endothelial cell injury by activating the miR-181d-5p/CDKN3 axis. Zhang M, et al. Artif Cells Nanomed Biotechnol, 2019 Dec. PMID 31352814
  4. Overexpression of Long Non-coding RNA 4933425B07Rik Causes Urinary Malformations in Mice. Tan L, et al. Front Cell Dev Biol, 2021. PMID 33681192, Free PMC Article
  5. PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair. Khoury-Haddad H, et al. Proc Natl Acad Sci U S A, 2014 Feb 18. PMID 24550317, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NEAT1 may exert a protective effect on HUVECs by regulating the miR-181d-5p/CDKN3A axis
    Title: Long non-coding RNA NEAT1 inhibits oxidative stress-induced vascular endothelial cell injury by activating the miR-181d-5p/CDKN3 axis.
  2. Knockdown of CDKN3 expression inhibited prostate cancer tumor growth in the nude mouse model.
    Title: Cyclin-dependent kinase inhibitor 3 (CDKN3) plays a critical role in prostate cancer via regulating cell cycle and DNA replication signaling.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cyclin-dependent kinase inhibitor 3
Names
CDK2-associated dual-specificity phosphatase
kinase-associated phosphatase
NP_001346970.1
NP_082498.1
XP_006519656.1
XP_006519657.1
XP_030103904.1
XP_036014748.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360041.1 → NP_001346970.1  cyclin-dependent kinase inhibitor 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AA218046, AA510251, BY084534
    Related
    ENSMUST00000226621.2
    Conserved Domains (1) summary
    pfam05706
    Location:1 → 168
    CDKN3; Cyclin-dependent kinase inhibitor 3 (CDKN3)

  2. NM_028222.2 → NP_082498.1  cyclin-dependent kinase inhibitor 3 isoform 2

    See identical proteins and their annotated locations for NP_082498.1

    Status: VALIDATED

    Source sequence(s)
    AA218046, BC049694, BY084534
    Consensus CDS
    CCDS49466.1
    UniProtKB/Swiss-Prot
    Q810P3, Q9CWS3
    Related
    ENSMUSP00000070575.5, ENSMUST00000067426.6
    Conserved Domains (1) summary
    pfam05706
    Location:1 → 167
    CDKN3; Cyclin-dependent kinase inhibitor 3 (CDKN3)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    46997912..47008987
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158855.1 → XP_036014748.1  cyclin-dependent kinase inhibitor 3 isoform X1

    UniProtKB/TrEMBL
    A0A2I3BPS7
    Related
    ENSMUSP00000154120.2, ENSMUST00000228106.2
    Conserved Domains (1) summary
    cl28904
    Location:1 → 139
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  2. XM_030248044.1 → XP_030103904.1  cyclin-dependent kinase inhibitor 3 isoform X3

    Conserved Domains (1) summary
    cl28904
    Location:17 → 153
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  3. XM_006519594.4 → XP_006519657.1  cyclin-dependent kinase inhibitor 3 isoform X2

    See identical proteins and their annotated locations for XP_006519657.1

    Conserved Domains (1) summary
    cl28904
    Location:17 → 154
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  4. XM_006519593.3 → XP_006519656.1  cyclin-dependent kinase inhibitor 3 isoform X2

    See identical proteins and their annotated locations for XP_006519656.1

    Conserved Domains (1) summary
    cl28904
    Location:17 → 154
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q810P3.1 GenPept UniProtKB/Swiss-Prot:Q810P3

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