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Obi1 ORC ubiquitin ligase 1 [ Mus musculus (house mouse) ]

Gene ID: 72486, updated on 9-Dec-2024

Summary

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Official Symbol
Obi1provided by MGI
Official Full Name
ORC ubiquitin ligase 1provided by MGI
Primary source
MGI:MGI:1919736
See related
Ensembl:ENSMUSG00000022120 AllianceGenome:MGI:1919736
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Obl1; Rnf219; 2610206B13Rik; 2810449K13Rik
Summary
Predicted to enable chromatin binding activity and ubiquitin-protein transferase activity. Acts upstream of or within positive regulation of mRNA splicing, via spliceosome. Predicted to be located in chromatin. Orthologous to human OBI1 (ORC ubiquitin ligase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in CNS E11.5 (RPKM 5.7), limb E14.5 (RPKM 3.7) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Obi1 in Genome Data Viewer
Location:
14 E2.3; 14 54.24 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (104714970..104760148, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (104477534..104522712, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D130079A08 gene Neighboring gene predicted gene, 35362 Neighboring gene POU domain, class 4, transcription factor 1 Neighboring gene predicted gene, 22021 Neighboring gene predicted gene, 35680

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RNF219 interacts with CCR4-NOT in regulating stem cell differentiation. Du H, et al. J Mol Cell Biol, 2020 Oct 26. PMID 33104214, Free PMC Article
  2. Ring finger protein 219 regulates inflammatory responses by stabilizing sirtuin 1. Hwang JS, et al. Br J Pharmacol, 2020 Oct. PMID 32220064, Free PMC Article
  3. Functional and comparative genomic analysis of the piebald deletion region of mouse chromosome 14. Peterson KA, et al. Genomics, 2002 Aug. PMID 12160731
  4. In vivo dual-tagging proteomic approach in studying signaling pathways in immune response. Wang T, et al. J Proteome Res, 2005 May-Jun. PMID 15952741
  5. A broadly applicable high-throughput screening strategy identifies new regulators of Dlg4 (Psd-95) alternative splicing. Zheng S, et al. Genome Res, 2013 Jun. PMID 23636947, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNF219 interacts with CCR4-NOT in regulating stem cell differentiation.
    Title: RNF219 interacts with CCR4-NOT in regulating stem cell differentiation.
  2. Ring finger protein 219 regulates inflammatory responses by stabilizing sirtuin 1.
    Title: Ring finger protein 219 regulates inflammatory responses by stabilizing sirtuin 1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC35679

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autoubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein monoubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA replication ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in chromatin ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
ORC ubiquitin ligase 1
Names
ring finger protein 219
NP_080323.3
XP_011243508.1
XP_036014750.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026047.4 → NP_080323.3  ORC ubiquitin ligase 1

    See identical proteins and their annotated locations for NP_080323.3

    Status: VALIDATED

    Source sequence(s)
    AC121997, BI986775, CN697474
    Consensus CDS
    CCDS27320.1
    UniProtKB/Swiss-Prot
    Q8K2Y0, Q9CYU1, Q9D1Y0
    UniProtKB/TrEMBL
    G3X8V5
    Related
    ENSMUSP00000022716.3, ENSMUST00000022716.4
    Conserved Domains (3) summary
    PHA03307
    Location:269 → 370
    PHA03307; transcriptional regulator ICP4; Provisional
    TIGR02168
    Location:90 → 307
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd16562
    Location:15 → 56
    RING-HC_RNF219; RING finger, HC subclass, found in RING finger protein 219 (RNF219) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    104714970..104760148 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158857.1 → XP_036014750.1  ORC ubiquitin ligase 1 isoform X1

  2. XM_011245206.3 → XP_011243508.1  ORC ubiquitin ligase 1 isoform X2

    See identical proteins and their annotated locations for XP_011243508.1

    UniProtKB/TrEMBL
    A0A2I3BRT6
    Related
    ENSMUSP00000154655.2, ENSMUST00000228448.2
    Conserved Domains (2) summary
    COG5432
    Location:18 → 165
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cd16562
    Location:15 → 56
    RING-HC_RNF219; RING finger, HC subclass, found in RING finger protein 219 (RNF219) and similar proteins

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_028253.1: Suppressed sequence

    Description
    NM_028253.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K2Y0.2 GenPept UniProtKB/Swiss-Prot:Q8K2Y0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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