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Lins1 lines homolog 1 [ Mus musculus (house mouse) ]

Gene ID: 72635, updated on 4-Jan-2025

Summary

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Official Symbol
Lins1provided by MGI
Official Full Name
lines homolog 1provided by MGI
Primary source
MGI:MGI:1919885
See related
Ensembl:ENSMUSG00000053091 AllianceGenome:MGI:1919885
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lins; Lins2; Wins2; 2700083B01Rik
Summary
Predicted to be involved in cognition. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 27. Orthologous to human LINS1 (lines homolog 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in limb E14.5 (RPKM 3.6), CNS E14 (RPKM 3.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Lins1 in Genome Data Viewer
Location:
7 C; 7 36.08 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (66339565..66367004)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (66689817..66717256)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_19085 Neighboring gene STARR-seq mESC enhancer starr_19088 Neighboring gene predicted gene, 53392 Neighboring gene predicted gene, 33570 Neighboring gene STARR-seq mESC enhancer starr_19090 Neighboring gene STARR-positive B cell enhancer ABC_E11356 Neighboring gene STARR-positive B cell enhancer ABC_E1735 Neighboring gene ankyrin repeat and SOCS box-containing 7 Neighboring gene STARR-seq mESC enhancer starr_19091 Neighboring gene ceramide synthase 3 Neighboring gene predicted gene, 33627 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of human WINS1 and mouse Wins2, homologous to Drosophila segment polarity gene Lines (Lin). Katoh M. Int J Mol Med, 2002 Aug. PMID 12119551
  2. Characterization of gene expression in mouse blastocyst using single-pass sequencing of 3995 clones. Sasaki N, et al. Genomics, 1998 Apr 15. PMID 9598303
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cognition IEA
Inferred from Electronic Annotation
more info
  
involved_in cognition ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
protein Lines homolog 1
Names
Wins2 protein with Drosophila Lin homologous domain
lines homolog 2
protein Lines homolog 2
protein with Drosophila Lines homologous domain
wnt-signaling molecule Lines homolog 1
wnt-signaling molecule Lines homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191001.1 → NP_001177930.1  protein Lines homolog 1 isoform 2

    See identical proteins and their annotated locations for NP_001177930.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AC120791
    Consensus CDS
    CCDS57555.1
    UniProtKB/Swiss-Prot
    Q3U1D0
    Related
    ENSMUSP00000077117.7, ENSMUST00000077967.13
    Conserved Domains (2) summary
    pfam14694
    Location:205 → 553
    LINES_N; Lines N-terminus
    pfam14695
    Location:718 → 754
    LINES_C; Lines C-terminus

  2. NM_152815.2 → NP_690028.2  protein Lines homolog 1 isoform 1

    See identical proteins and their annotated locations for NP_690028.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC120791
    Consensus CDS
    CCDS21348.2
    UniProtKB/Swiss-Prot
    Q3TBL8, Q3U1D0, Q6PCP6, Q8K4P9
    Related
    ENSMUSP00000112404.3, ENSMUST00000121777.9
    Conserved Domains (2) summary
    pfam14694
    Location:211 → 558
    LINES_N; Lines N-terminus
    pfam14695
    Location:723 → 758
    LINES_C; Lines C-terminus

RNA

  1. NR_034030.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses alternate splice sites in two internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC120791, BC058648
    Related
    ENSMUST00000130161.9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    66339565..66367004
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006541219.4 → XP_006541282.1  protein Lines homolog 1 isoform X2

    Conserved Domains (2) summary
    pfam14694
    Location:175 → 523
    LINES_N; Lines N-terminus
    pfam14695
    Location:688 → 724
    LINES_C; Lines C-terminus

  2. XM_006541218.5 → XP_006541281.1  protein Lines homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_006541281.1

    UniProtKB/Swiss-Prot
    Q3U1D0
    Conserved Domains (2) summary
    pfam14694
    Location:205 → 553
    LINES_N; Lines N-terminus
    pfam14695
    Location:718 → 754
    LINES_C; Lines C-terminus

  3. XM_036153460.1 → XP_036009353.1  protein Lines homolog 1 isoform X6

    Conserved Domains (2) summary
    pfam14694
    Location:1 → 292
    LINES_N; Lines N-terminus
    pfam14695
    Location:457 → 493
    LINES_C; Lines C-terminus

  4. XM_030243014.1 → XP_030098874.1  protein Lines homolog 1 isoform X6

    Conserved Domains (2) summary
    pfam14694
    Location:1 → 292
    LINES_N; Lines N-terminus
    pfam14695
    Location:457 → 493
    LINES_C; Lines C-terminus

  5. XM_006541217.5 → XP_006541280.1  protein Lines homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_006541280.1

    UniProtKB/Swiss-Prot
    Q3U1D0
    Conserved Domains (2) summary
    pfam14694
    Location:205 → 553
    LINES_N; Lines N-terminus
    pfam14695
    Location:718 → 754
    LINES_C; Lines C-terminus

  6. XM_030243012.2 → XP_030098872.1  protein Lines homolog 1 isoform X4

    Conserved Domains (2) summary
    pfam14694
    Location:144 → 492
    LINES_N; Lines N-terminus
    pfam14695
    Location:657 → 693
    LINES_C; Lines C-terminus

  7. XM_006541220.5 → XP_006541283.1  protein Lines homolog 1 isoform X3

    Conserved Domains (2) summary
    pfam14694
    Location:174 → 522
    LINES_N; Lines N-terminus
    pfam14695
    Location:687 → 723
    LINES_C; Lines C-terminus

  8. XM_011250905.4 → XP_011249207.1  protein Lines homolog 1 isoform X6

    See identical proteins and their annotated locations for XP_011249207.1

    UniProtKB/Swiss-Prot
    Q3U1D0
    Conserved Domains (2) summary
    pfam14694
    Location:1 → 292
    LINES_N; Lines N-terminus
    pfam14695
    Location:457 → 493
    LINES_C; Lines C-terminus

  9. XM_036153457.1 → XP_036009350.1  protein Lines homolog 1 isoform X4

    Conserved Domains (2) summary
    pfam14694
    Location:144 → 492
    LINES_N; Lines N-terminus
    pfam14695
    Location:657 → 693
    LINES_C; Lines C-terminus

  10. XM_036153458.1 → XP_036009351.1  protein Lines homolog 1 isoform X5

    Conserved Domains (2) summary
    pfam14694
    Location:146 → 452
    LINES_N; Lines N-terminus
    pfam14695
    Location:617 → 653
    LINES_C; Lines C-terminus

  11. XM_036153459.1 → XP_036009352.1  protein Lines homolog 1 isoform X6

    Conserved Domains (2) summary
    pfam14694
    Location:1 → 292
    LINES_N; Lines N-terminus
    pfam14695
    Location:457 → 493
    LINES_C; Lines C-terminus

  12. XM_017312329.1 → XP_017167818.1  protein Lines homolog 1 isoform X6

    UniProtKB/Swiss-Prot
    Q3U1D0
    Conserved Domains (2) summary
    pfam14694
    Location:1 → 292
    LINES_N; Lines N-terminus
    pfam14695
    Location:457 → 493
    LINES_C; Lines C-terminus

  13. XM_036153461.1 → XP_036009354.1  protein Lines homolog 1 isoform X6

    Conserved Domains (2) summary
    pfam14694
    Location:1 → 292
    LINES_N; Lines N-terminus
    pfam14695
    Location:457 → 493
    LINES_C; Lines C-terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U1D0.2 GenPept UniProtKB/Swiss-Prot:Q3U1D0

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