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Zfp618 zinc finger protein 618 [ Mus musculus (house mouse) ]

Gene ID: 72701, updated on 9-Dec-2024

Summary

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Official Symbol
Zfp618provided by MGI
Official Full Name
zinc finger protein 618provided by MGI
Primary source
MGI:MGI:1919950
See related
Ensembl:ENSMUSG00000028358 AllianceGenome:MGI:1919950
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nedd10; Znf618; bM257P7.1; 2810031P15Rik; 2810040O04Rik; D430033D05Rik
Summary
Predicted to enable identical protein binding activity and transcription coregulator binding activity. Predicted to be located in pericentric heterochromatin. Is expressed in early bud stage tooth; ganglionic eminence; mandibular process; oral epithelium; and oral region mesenchyme. Orthologous to human ZNF618 (zinc finger protein 618). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in limb E14.5 (RPKM 11.3), CNS E11.5 (RPKM 10.0) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp618 in Genome Data Viewer
Location:
4 B3; 4 33.82 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (62883792..63057946)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (62965555..63139709)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24117 Neighboring gene STARR-seq mESC enhancer starr_10433 Neighboring gene predicted gene, 25391 Neighboring gene predicted gene, 30764 Neighboring gene alpha 1 microglobulin/bikunin precursor Neighboring gene kinesin family member 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coregulator binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coregulator binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of chromatin binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in pericentric heterochromatin IEA
Inferred from Electronic Annotation
more info
  
located_in pericentric heterochromatin ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein 618
Names
neural precursor cell expressed, developmentally down-regulated gene 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369113.1 → NP_001356042.1  zinc finger protein 618 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL691431, AL691496
    Conserved Domains (1) summary
    sd00017
    Location:116 → 136
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001369114.1 → NP_001356043.1  zinc finger protein 618 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL691431, AL691496
    Conserved Domains (1) summary
    sd00017
    Location:116 → 136
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001369115.1 → NP_001356044.1  zinc finger protein 618 isoform e

    Status: VALIDATED

    Source sequence(s)
    AL691431, AL691496
    Conserved Domains (1) summary
    sd00017
    Location:92 → 112
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_001369116.1 → NP_001356045.1  zinc finger protein 618 isoform f

    Status: VALIDATED

    Source sequence(s)
    AL691431, AL691496
    Conserved Domains (1) summary
    sd00017
    Location:92 → 112
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. NM_001369117.1 → NP_001356046.1  zinc finger protein 618 isoform g

    Status: VALIDATED

    Source sequence(s)
    AL691431, AL691496
    Conserved Domains (1) summary
    sd00017
    Location:60 → 80
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. NM_001369118.1 → NP_001356047.1  zinc finger protein 618 isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variant 9, encodes isoform h.
    Source sequence(s)
    AL691431, AL691496
    Conserved Domains (1) summary
    sd00017
    Location:60 → 80
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. NM_001369119.1 → NP_001356048.1  zinc finger protein 618 isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variant 8, encodes isoform h.
    Source sequence(s)
    AL691431, AL691496
    Conserved Domains (1) summary
    sd00017
    Location:60 → 80
    ZF_C2H2; C2H2 Zn finger [structural motif]

  8. NM_028326.2 → NP_082602.1  zinc finger protein 618 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL691431, AL691496
    Consensus CDS
    CCDS51203.1
    UniProtKB/TrEMBL
    F8WIU3
    Related
    ENSMUSP00000069275.6, ENSMUST00000064814.6
    Conserved Domains (1) summary
    sd00017
    Location:116 → 136
    ZF_C2H2; C2H2 Zn finger [structural motif]

  9. NM_028327.1 → NP_082603.1  zinc finger protein 618 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AL691431, AL691496
    Consensus CDS
    CCDS89760.1
    UniProtKB/Swiss-Prot
    Q69Z57, Q80YY7, Q80YY8, Q9CZ99
    Related
    ENSMUSP00000103038.2, ENSMUST00000107415.8
    Conserved Domains (1) summary
    sd00017
    Location:148 → 168
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    62883792..63057946
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538286.1 → XP_006538349.1  zinc finger protein 618 isoform X18

    See identical proteins and their annotated locations for XP_006538349.1

    Conserved Domains (2) summary
    sd00017
    Location:92 → 112
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05699
    Location:839 → 919
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region

  2. XM_006538288.1 → XP_006538351.1  zinc finger protein 618 isoform X19

    Conserved Domains (2) summary
    sd00017
    Location:92 → 112
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05699
    Location:831 → 911
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region

  3. XM_030253817.1 → XP_030109677.1  zinc finger protein 618 isoform X20

    Conserved Domains (2) summary
    sd00017
    Location:60 → 80
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05699
    Location:807 → 887
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region

  4. XM_030253818.1 → XP_030109678.1  zinc finger protein 618 isoform X21

    Conserved Domains (2) summary
    sd00017
    Location:60 → 80
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05699
    Location:799 → 879
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region

  5. XM_030253814.1 → XP_030109674.1  zinc finger protein 618 isoform X12

    Conserved Domains (2) summary
    sd00017
    Location:148 → 168
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05699
    Location:895 → 975
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region

  6. XM_030253815.1 → XP_030109675.1  zinc finger protein 618 isoform X13

    Conserved Domains (2) summary
    sd00017
    Location:148 → 168
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05699
    Location:887 → 967
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region

  7. XM_036164467.1 → XP_036020360.1  zinc finger protein 618 isoform X14

    Conserved Domains (1) summary
    sd00017
    Location:148 → 168
    ZF_C2H2; C2H2 Zn finger [structural motif]

  8. XM_036164468.1 → XP_036020361.1  zinc finger protein 618 isoform X15

    Conserved Domains (1) summary
    sd00017
    Location:148 → 168
    ZF_C2H2; C2H2 Zn finger [structural motif]

  9. XM_030253816.1 → XP_030109676.1  zinc finger protein 618 isoform X16

    Conserved Domains (2) summary
    sd00017
    Location:116 → 136
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05699
    Location:863 → 943
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region

  10. XM_036164469.1 → XP_036020362.1  zinc finger protein 618 isoform X17

    Conserved Domains (1) summary
    sd00017
    Location:116 → 136
    ZF_C2H2; C2H2 Zn finger [structural motif]

  11. XM_006538287.3 → XP_006538350.1  zinc finger protein 618 isoform X18

    See identical proteins and their annotated locations for XP_006538350.1

    Conserved Domains (2) summary
    sd00017
    Location:92 → 112
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05699
    Location:839 → 919
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region

  12. XM_006538279.3 → XP_006538342.2  zinc finger protein 618 isoform X1

    Conserved Domains (2) summary
    sd00017
    Location:144 → 164
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05699
    Location:891 → 971
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region

  13. XM_006538282.3 → XP_006538345.2  zinc finger protein 618 isoform X4

    Conserved Domains (2) summary
    sd00017
    Location:144 → 164
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05699
    Location:876 → 956
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region

  14. XM_006538280.3 → XP_006538343.2  zinc finger protein 618 isoform X2

    Conserved Domains (2) summary
    sd00017
    Location:144 → 164
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05699
    Location:890 → 970
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region

  15. XM_030253812.1 → XP_030109672.1  zinc finger protein 618 isoform X5

    Conserved Domains (2) summary
    sd00017
    Location:144 → 164
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05699
    Location:875 → 955
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region

  16. XM_006538281.3 → XP_006538344.2  zinc finger protein 618 isoform X3

    Conserved Domains (2) summary
    sd00017
    Location:144 → 164
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05699
    Location:883 → 963
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region

  17. XM_017320394.2 → XP_017175883.1  zinc finger protein 618 isoform X6

    Conserved Domains (2) summary
    sd00017
    Location:144 → 164
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05699
    Location:868 → 948
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region

  18. XM_030253813.1 → XP_030109673.1  zinc finger protein 618 isoform X7

    Conserved Domains (2) summary
    sd00017
    Location:144 → 164
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05699
    Location:867 → 947
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region

  19. XM_006538283.3 → XP_006538346.2  zinc finger protein 618 isoform X8

    Conserved Domains (2) summary
    sd00017
    Location:112 → 132
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05699
    Location:859 → 939
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region

  20. XM_006538284.3 → XP_006538347.2  zinc finger protein 618 isoform X9

    Conserved Domains (2) summary
    sd00017
    Location:112 → 132
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05699
    Location:851 → 931
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region

  21. XM_006538291.3 → XP_006538354.2  zinc finger protein 618 isoform X10

    Conserved Domains (2) summary
    sd00017
    Location:112 → 132
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05699
    Location:836 → 916
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region

  22. XM_017320395.2 → XP_017175884.1  zinc finger protein 618 isoform X11

    Conserved Domains (2) summary
    sd00017
    Location:112 → 132
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05699
    Location:835 → 915
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region

  23. XM_006538289.1 → XP_006538352.1  zinc finger protein 618 isoform X22

RNA

  1. XR_003955017.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80YY7.3 GenPept UniProtKB/Swiss-Prot:Q80YY7

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