Tbcc tubulin-specific chaperone C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tbccprovided by MGI
Official Full Name: tubulin-specific chaperone Cprovided by MGI
Primary source: MGI:MGI:1919976
See related: Ensembl:ENSMUSG00000036430 AllianceGenome:MGI:1919976
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2810055C19Rik
Summary: Predicted to enable GTPase activity. Predicted to be involved in post-chaperonin tubulin folding pathway and tubulin complex assembly. Predicted to be located in cytosol and photoreceptor connecting cilium. Predicted to be active in cytoplasm. Is expressed in Meckel's cartilage; autopod; and skeleton. Orthologous to human TBCC (tubulin folding cofactor C). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 17 C; 17 22.9 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (47201547..47203389)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (46890621..46892463)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables tubulin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in post-chaperonin tubulin folding pathway	ISO Inferred from Sequence Orthology more info
involved_in post-chaperonin tubulin folding pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in tubulin complex assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in photoreceptor connecting cilium	ISO Inferred from Sequence Orthology more info
located_in photoreceptor connecting cilium	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: tubulin-specific chaperone C

Names: CFC; tubulin-folding cofactor C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178385.3 → NP_848472.2 tubulin-specific chaperone C

See identical proteins and their annotated locations for NP_848472.2

Status: VALIDATED

Source sequence(s)

AK132036, BY299869

Consensus CDS

CCDS28843.1

UniProtKB/Swiss-Prot

Q3V242, Q8VCN9

UniProtKB/TrEMBL

A0A0R4J0M1

Related

ENSMUSP00000048696.8, ENSMUST00000040434.9

Conserved Domains (2) summary

pfam07986
Location:199 → 316

TBCC; Tubulin binding cofactor C

pfam16752
Location:28 → 134

TBCC_N; Tubulin-specific chaperone C N-terminal domain