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Eldr Egfr long non-coding downstream RNA [ Mus musculus (house mouse) ]

Gene ID: 72735, updated on 9-Dec-2024

Summary

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Official Symbol
Eldrprovided by MGI
Official Full Name
Egfr long non-coding downstream RNAprovided by MGI
Primary source
MGI:MGI:1919985
See related
Ensembl:ENSMUSG00000087060 AllianceGenome:MGI:1919985
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fabl; 2810442I21Rik; 4930500E12Rik
Summary
Acts upstream of or within regulation of gene expression and response to wounding. Is expressed in brain; cortical layer VI; neocortex; telencephalon mantle layer; and telencephalon ventricular layer. Orthologous to human ELDR (EGFR long non-coding downstream RNA). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in CNS E11.5 (RPKM 3.2), limb E14.5 (RPKM 2.1) and 12 other tissues See more
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Genomic context

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See Eldr in Genome Data Viewer
Location:
11 A2; 11 9.41 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (16884709..16901282, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (16934709..16951282, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene epidermal growth factor receptor Neighboring gene predicted gene, 39584 Neighboring gene STARR-seq mESC enhancer starr_28696 Neighboring gene epidermal growth factor receptor, opposite strand Neighboring gene STARR-seq mESC enhancer starr_28697 Neighboring gene STARR-seq mESC enhancer starr_28698 Neighboring gene STARR-seq mESC enhancer starr_28699 Neighboring gene STARR-seq mESC enhancer starr_28700 Neighboring gene F-box protein 48 Neighboring gene STARR-positive B cell enhancer ABC_E8386 Neighboring gene pleckstrin Neighboring gene STARR-positive B cell enhancer ABC_E1819 Neighboring gene signal peptide, CUB domain, EGF-like 3 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Emerging role of lncRNA ELDR in development and cancer. Sur S, et al. FEBS J, 2022 Jun. PMID 33860640
  2. Dynamic chromatin accessibility tuning by the long noncoding RNA ELDR accelerates chondrocyte senescence and osteoarthritis. Ji ML, et al. Am J Hum Genet, 2023 Apr 6. PMID 36868238, Free PMC Article
  3. Spatiotemporal expression and transcriptional perturbations by long noncoding RNAs in the mouse brain. Goff LA, et al. Proc Natl Acad Sci U S A, 2015 Jun 2. PMID 26034286, Free PMC Article
  4. Diverse Phenotypes and Specific Transcription Patterns in Twenty Mouse Lines with Ablated LincRNAs. Lai KM, et al. PLoS One, 2015. PMID 25909911, Free PMC Article
  5. Identification of candidate long non-coding RNAs in response to myocardial infarction. Zangrando J, et al. BMC Genomics, 2014 Jun 10. PMID 24917243, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dynamic chromatin accessibility tuning by the long noncoding RNA ELDR accelerates chondrocyte senescence and osteoarthritis.
    Title: Dynamic chromatin accessibility tuning by the long noncoding RNA ELDR accelerates chondrocyte senescence and osteoarthritis.
  2. Emerging role of lncRNA ELDR in development and cancer.
    Title: Emerging role of lncRNA ELDR in development and cancer.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to wounding IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_110421.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AK015657, AL645532, BI990615

  2. NR_110422.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon and uses an alternate splice site at the 3' terminal exon, resulting in a shorter transcript, compared to variant 1.
    Source sequence(s)
    AK015657, AL645532

  3. NR_110423.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate internal exons and uses an alternate splice site at the 5' terminal exon, resulting in a shorter transcript, compared to variant 1.
    Source sequence(s)
    AL645532

  4. NR_110424.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate internal exons, resulting in a shorter transcript, compared to variant 1.
    Source sequence(s)
    AK013290, AK015657, AL645532, BI990615
    Related
    ENSMUST00000123734.10

  5. NR_110425.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two alternate internal exons and uses an alternate splice site at the 3' terminal exon, resulting in a shorter transcript, compared to variant 1.
    Source sequence(s)
    AK013290, AK015657, AL645532
    Related
    ENSMUST00000139493.10

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    16884709..16901282 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_015469.1: Suppressed sequence

    Description
    NR_015469.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version

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