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MROH1 maestro heat like repeat family member 1 [ Homo sapiens (human) ]

Gene ID: 727957, updated on 10-Dec-2024

Summary

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Official Symbol
MROH1provided by HGNC
Official Full Name
maestro heat like repeat family member 1provided by HGNC
Primary source
HGNC:HGNC:26958
See related
Ensembl:ENSG00000179832 AllianceGenome:HGNC:26958
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HEATR7A
Summary
Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in thyroid (RPKM 7.3), bone marrow (RPKM 4.8) and 25 other tissues See more
Orthologs
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Genomic context

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See MROH1 in Genome Data Viewer
Location:
8q24.3
Exon count:
52
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (144148016..144261926)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (145314737..145430696)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (145202919..145316829)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19659 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19660 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19661 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19662 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19663 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19664 Neighboring gene testis specific serine kinase 5, pseudogene Neighboring gene HGH1 homolog Neighboring gene ReSE screen-validated silencer GRCh37_chr8:145220181-145220332 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145220890-145221390 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145222845-145223346 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145223347-145223846 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145225713-145226214 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145233092-145233905 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145235445-145236162 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:145236968-145237140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145239293-145239836 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19665 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19666 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145321725-145322492 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:145322493-145323258 Neighboring gene microRNA 7112 Neighboring gene BOP1 ribosomal biogenesis factor Neighboring gene scleraxis bHLH transcription factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. The HEAT repeat protein HPO-27 is a lysosome fission factor. Li L, et al. Nature, 2024 Apr. PMID 38538795
  2. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2001 Apr 27. PMID 11347906
  3. The sequence of the human genome. Venter JC, et al. Science, 2001 Feb 16. PMID 11181995
  4. Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. Stukalov A, et al. Nature, 2021 Jun. PMID 33845483
  5. A dual-activity topoisomerase complex regulates mRNA translation and turnover. Su S, et al. Nucleic Acids Res, 2022 Jul 8. PMID 35748872, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The HEAT repeat protein HPO-27 is a lysosome fission factor.
    Title: The HEAT repeat protein HPO-27 is a lysosome fission factor.
  2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ13324, FLJ35542, FLJ36244, FLJ36266, FLJ42560, KIAA1833, MGC50841, DKFZp434P167, DKFZp434I0113

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
maestro heat-like repeat-containing protein family member 1
Names
HEAT repeat containing 7A
HEAT repeat-containing protein 7A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099280.3 → NP_001092750.2  maestro heat-like repeat-containing protein family member 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks multiple exons but has an alternate 3' terminal exon, compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform 2.
    Source sequence(s)
    AC104592
    Consensus CDS
    CCDS47939.1

  2. NM_001099281.3 → NP_001092751.2  maestro heat-like repeat-containing protein family member 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an internal exon in the 5' UTR and multiple exons in the 3' half but has an alternate 3' terminal exon, compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform 2.
    Source sequence(s)
    AC104592
    Consensus CDS
    CCDS47939.1
    Related
    ENSP00000388174.2, ENST00000423230.6

  3. NM_001288814.2 → NP_001275743.2  maestro heat-like repeat-containing protein family member 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame coding exon in the central region, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC104592, AC145291
    Consensus CDS
    CCDS75803.1
    UniProtKB/TrEMBL
    E9PHY8
    Related
    ENSP00000436636.1, ENST00000534366.5

  4. NM_032450.3 → NP_115826.3  maestro heat-like repeat-containing protein family member 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC104592, AC145291, AL834309, CN333563, DA934047
    Consensus CDS
    CCDS47938.1
    UniProtKB/Swiss-Prot
    C9JWM5, D3DWL5, Q0P612, Q569G6, Q6NVW4, Q8N230, Q8NAD1, Q8ND95, Q8NDA8, Q96JJ4
    Related
    ENSP00000321737.5, ENST00000326134.10

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    144148016..144261926
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422170.1 → XP_047278126.1  maestro heat-like repeat-containing protein family member 1 isoform X1

  2. XM_047422189.1 → XP_047278145.1  maestro heat-like repeat-containing protein family member 1 isoform X7

  3. XM_047422176.1 → XP_047278132.1  maestro heat-like repeat-containing protein family member 1 isoform X3

  4. XM_047422179.1 → XP_047278135.1  maestro heat-like repeat-containing protein family member 1 isoform X4

  5. XM_047422182.1 → XP_047278138.1  maestro heat-like repeat-containing protein family member 1 isoform X6

    UniProtKB/TrEMBL
    E9PHY8

  6. XM_047422191.1 → XP_047278147.1  maestro heat-like repeat-containing protein family member 1 isoform X9

  7. XM_047422172.1 → XP_047278128.1  maestro heat-like repeat-containing protein family member 1 isoform X1

  8. XM_047422178.1 → XP_047278134.1  maestro heat-like repeat-containing protein family member 1 isoform X3

  9. XM_047422185.1 → XP_047278141.1  maestro heat-like repeat-containing protein family member 1 isoform X6

    UniProtKB/TrEMBL
    E9PHY8

  10. XM_047422171.1 → XP_047278127.1  maestro heat-like repeat-containing protein family member 1 isoform X1

  11. XM_047422175.1 → XP_047278131.1  maestro heat-like repeat-containing protein family member 1 isoform X2

  12. XM_047422181.1 → XP_047278137.1  maestro heat-like repeat-containing protein family member 1 isoform X5

    UniProtKB/Swiss-Prot
    C9JWM5, D3DWL5, Q0P612, Q569G6, Q6NVW4, Q8N230, Q8NAD1, Q8ND95, Q8NDA8, Q96JJ4

  13. XM_047422190.1 → XP_047278146.1  maestro heat-like repeat-containing protein family member 1 isoform X7

  14. XM_047422177.1 → XP_047278133.1  maestro heat-like repeat-containing protein family member 1 isoform X3

  15. XM_047422180.1 → XP_047278136.1  maestro heat-like repeat-containing protein family member 1 isoform X4

  16. XM_047422183.1 → XP_047278139.1  maestro heat-like repeat-containing protein family member 1 isoform X6

    UniProtKB/TrEMBL
    E9PHY8

  17. XM_047422193.1 → XP_047278149.1  maestro heat-like repeat-containing protein family member 1 isoform X9

  18. XM_047422198.1 → XP_047278154.1  maestro heat-like repeat-containing protein family member 1 isoform X13

    UniProtKB/TrEMBL
    B4DIR5
    Related
    ENST00000532255.5

  19. XM_047422199.1 → XP_047278155.1  maestro heat-like repeat-containing protein family member 1 isoform X16

    UniProtKB/TrEMBL
    B4DIR5

  20. XM_047422173.1 → XP_047278129.1  maestro heat-like repeat-containing protein family member 1 isoform X1

  21. XM_047422184.1 → XP_047278140.1  maestro heat-like repeat-containing protein family member 1 isoform X6

    UniProtKB/TrEMBL
    E9PHY8

  22. XM_047422192.1 → XP_047278148.1  maestro heat-like repeat-containing protein family member 1 isoform X9

  23. XM_011517270.3 → XP_011515572.2  maestro heat-like repeat-containing protein family member 1 isoform X1

  24. XM_011517271.3 → XP_011515573.2  maestro heat-like repeat-containing protein family member 1 isoform X2

  25. XM_011517273.3 → XP_011515575.2  maestro heat-like repeat-containing protein family member 1 isoform X5

    UniProtKB/Swiss-Prot
    C9JWM5, D3DWL5, Q0P612, Q569G6, Q6NVW4, Q8N230, Q8NAD1, Q8ND95, Q8NDA8, Q96JJ4
    Related
    ENSP00000435565.1, ENST00000528919.5

  26. XM_047422168.1 → XP_047278124.1  maestro heat-like repeat-containing protein family member 1 isoform X7

  27. XM_047422167.1 → XP_047278123.1  maestro heat-like repeat-containing protein family member 1 isoform X3

  28. XM_017013802.3 → XP_016869291.2  maestro heat-like repeat-containing protein family member 1 isoform X4

  29. XM_011517274.3 → XP_011515576.2  maestro heat-like repeat-containing protein family member 1 isoform X6

    UniProtKB/TrEMBL
    E9PHY8

  30. XM_017013803.3 → XP_016869292.2  maestro heat-like repeat-containing protein family member 1 isoform X9

  31. XM_047422174.1 → XP_047278130.1  maestro heat-like repeat-containing protein family member 1 isoform X1

  32. XM_047422169.1 → XP_047278125.1  maestro heat-like repeat-containing protein family member 1 isoform X8

  33. XM_047422186.1 → XP_047278142.1  maestro heat-like repeat-containing protein family member 1 isoform X10

  34. XM_047422194.1 → XP_047278150.1  maestro heat-like repeat-containing protein family member 1 isoform X12

    UniProtKB/TrEMBL
    B4DIR5

  35. XM_047422195.1 → XP_047278151.1  maestro heat-like repeat-containing protein family member 1 isoform X13

    UniProtKB/TrEMBL
    B4DIR5

  36. XM_047422196.1 → XP_047278152.1  maestro heat-like repeat-containing protein family member 1 isoform X14

    UniProtKB/TrEMBL
    B4DIR5

  37. XM_047422197.1 → XP_047278153.1  maestro heat-like repeat-containing protein family member 1 isoform X15

    UniProtKB/TrEMBL
    B4DIR5

  38. XM_011517286.3 → XP_011515588.2  maestro heat-like repeat-containing protein family member 1 isoform X17

  39. XM_047422187.1 → XP_047278143.1  maestro heat-like repeat-containing protein family member 1 isoform X11

  40. XM_047422188.1 → XP_047278144.1  maestro heat-like repeat-containing protein family member 1 isoform X11

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    145314737..145430696
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361144.1 → XP_054217119.1  maestro heat-like repeat-containing protein family member 1 isoform X1

  2. XM_054361163.1 → XP_054217138.1  maestro heat-like repeat-containing protein family member 1 isoform X7

  3. XM_054361150.1 → XP_054217125.1  maestro heat-like repeat-containing protein family member 1 isoform X3

  4. XM_054361153.1 → XP_054217128.1  maestro heat-like repeat-containing protein family member 1 isoform X4

  5. XM_054361156.1 → XP_054217131.1  maestro heat-like repeat-containing protein family member 1 isoform X6

  6. XM_054361165.1 → XP_054217140.1  maestro heat-like repeat-containing protein family member 1 isoform X9

  7. XM_054361146.1 → XP_054217121.1  maestro heat-like repeat-containing protein family member 1 isoform X1

  8. XM_054361152.1 → XP_054217127.1  maestro heat-like repeat-containing protein family member 1 isoform X3

  9. XM_054361159.1 → XP_054217134.1  maestro heat-like repeat-containing protein family member 1 isoform X6

  10. XM_054361145.1 → XP_054217120.1  maestro heat-like repeat-containing protein family member 1 isoform X1

  11. XM_054361149.1 → XP_054217124.1  maestro heat-like repeat-containing protein family member 1 isoform X2

  12. XM_054361155.1 → XP_054217130.1  maestro heat-like repeat-containing protein family member 1 isoform X5

  13. XM_054361164.1 → XP_054217139.1  maestro heat-like repeat-containing protein family member 1 isoform X7

  14. XM_054361151.1 → XP_054217126.1  maestro heat-like repeat-containing protein family member 1 isoform X3

  15. XM_054361154.1 → XP_054217129.1  maestro heat-like repeat-containing protein family member 1 isoform X4

  16. XM_054361157.1 → XP_054217132.1  maestro heat-like repeat-containing protein family member 1 isoform X6

  17. XM_054361167.1 → XP_054217142.1  maestro heat-like repeat-containing protein family member 1 isoform X9

  18. XM_054361172.1 → XP_054217147.1  maestro heat-like repeat-containing protein family member 1 isoform X13

    UniProtKB/TrEMBL
    B4DIR5

  19. XM_054361173.1 → XP_054217148.1  maestro heat-like repeat-containing protein family member 1 isoform X16

    UniProtKB/TrEMBL
    B4DIR5

  20. XM_054361147.1 → XP_054217122.1  maestro heat-like repeat-containing protein family member 1 isoform X1

  21. XM_054361158.1 → XP_054217133.1  maestro heat-like repeat-containing protein family member 1 isoform X6

  22. XM_054361166.1 → XP_054217141.1  maestro heat-like repeat-containing protein family member 1 isoform X9

  23. XM_054361135.1 → XP_054217110.1  maestro heat-like repeat-containing protein family member 1 isoform X1

  24. XM_054361136.1 → XP_054217111.1  maestro heat-like repeat-containing protein family member 1 isoform X2

  25. XM_054361139.1 → XP_054217114.1  maestro heat-like repeat-containing protein family member 1 isoform X5

  26. XM_054361141.1 → XP_054217116.1  maestro heat-like repeat-containing protein family member 1 isoform X7

  27. XM_054361137.1 → XP_054217112.1  maestro heat-like repeat-containing protein family member 1 isoform X3

  28. XM_054361138.1 → XP_054217113.1  maestro heat-like repeat-containing protein family member 1 isoform X4

  29. XM_054361140.1 → XP_054217115.1  maestro heat-like repeat-containing protein family member 1 isoform X6

  30. XM_054361143.1 → XP_054217118.1  maestro heat-like repeat-containing protein family member 1 isoform X9

  31. XM_054361148.1 → XP_054217123.1  maestro heat-like repeat-containing protein family member 1 isoform X1

  32. XM_054361142.1 → XP_054217117.1  maestro heat-like repeat-containing protein family member 1 isoform X8

  33. XM_054361160.1 → XP_054217135.1  maestro heat-like repeat-containing protein family member 1 isoform X10

  34. XM_054361168.1 → XP_054217143.1  maestro heat-like repeat-containing protein family member 1 isoform X12

    UniProtKB/TrEMBL
    B4DIR5

  35. XM_054361169.1 → XP_054217144.1  maestro heat-like repeat-containing protein family member 1 isoform X13

    UniProtKB/TrEMBL
    B4DIR5

  36. XM_054361170.1 → XP_054217145.1  maestro heat-like repeat-containing protein family member 1 isoform X14

    UniProtKB/TrEMBL
    B4DIR5

  37. XM_054361171.1 → XP_054217146.1  maestro heat-like repeat-containing protein family member 1 isoform X15

    UniProtKB/TrEMBL
    B4DIR5

  38. XM_054361174.1 → XP_054217149.1  maestro heat-like repeat-containing protein family member 1 isoform X17

  39. XM_054361161.1 → XP_054217136.1  maestro heat-like repeat-containing protein family member 1 isoform X11

  40. XM_054361162.1 → XP_054217137.1  maestro heat-like repeat-containing protein family member 1 isoform X11

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NDA8.3 GenPept UniProtKB/Swiss-Prot:Q8NDA8

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