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Bbof1 basal body orientation factor 1 [ Mus musculus (house mouse) ]

Gene ID: 72873, updated on 9-Aug-2024

Summary

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Official Symbol
Bbof1provided by MGI
Official Full Name
basal body orientation factor 1provided by MGI
Primary source
MGI:MGI:1920123
See related
Ensembl:ENSMUSG00000057265 AllianceGenome:MGI:1920123
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ccdc176; 2900006K08Rik
Summary
Predicted to be located in ciliary basal body and cytoplasm. Orthologous to human BBOF1 (basal body orientation factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 5.8), kidney adult (RPKM 4.1) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Bbof1 in Genome Data Viewer
Location:
12 D1; 12 39.2 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (84455243..84488279)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (84408461..84441428)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 410 Neighboring gene LSM6 homolog, U6 small nuclear RNA associated pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1445 Neighboring gene family with sequence similarity 161, member B Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:85729760-85729947 Neighboring gene coenzyme Q6 monooxygenase Neighboring gene ectonucleoside triphosphate diphosphohydrolase 5 Neighboring gene STARR-positive B cell enhancer ABC_E8493 Neighboring gene ring finger protein 113A2 Neighboring gene aldehyde dehydrogenase family 6, subfamily A1 Neighboring gene STARR-positive B cell enhancer ABC_E80 Neighboring gene lin-52 DREAM MuvB core complex component Neighboring gene STARR-seq mESC enhancer starr_32738 Neighboring gene STARR-seq mESC enhancer starr_32740 Neighboring gene STARR-seq mESC enhancer starr_32741 Neighboring gene visual system homeobox 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. BBOF1 is required for sperm motility and male fertility by stabilizing the flagellar axoneme in mice. Cao H, et al. Cell Mol Life Sci, 2023 May 17. PMID 37198331, Free PMC Article
  2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CCDC176 stabilizes microtubule doublets 1 and 9 to ensure proper sperm movement.
    Title: CCDC176 stabilizes microtubule doublets 1 and 9 to ensure proper sperm movement.
  2. BBOF1 is required for sperm motility and male fertility by stabilizing the flagellar axoneme in mice.
    Title: BBOF1 is required for sperm motility and male fertility by stabilizing the flagellar axoneme in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sperm axoneme assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axoneme IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
basal body-orientation factor 1
Names
coiled-coil domain containing 176
coiled-coil domain-containing protein 176

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028377.3 → NP_082653.2  basal body-orientation factor 1

    See identical proteins and their annotated locations for NP_082653.2

    Status: VALIDATED

    Source sequence(s)
    AK013494, AK133381, BC151103
    Consensus CDS
    CCDS36492.1
    UniProtKB/Swiss-Prot
    B9EKT3, Q3V079, Q9CUZ3
    Related
    ENSMUSP00000080512.7, ENSMUST00000081828.13
    Conserved Domains (1) summary
    pfam14988
    Location:83 → 276
    DUF4515; Domain of unknown function (DUF4515)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    84455243..84488279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246946.2 → XP_030102806.1  basal body-orientation factor 1 isoform X1

    Conserved Domains (1) summary
    pfam14988
    Location:83 → 219
    DUF4515; Domain of unknown function (DUF4515)

  2. XM_030246947.2 → XP_030102807.1  basal body-orientation factor 1 isoform X2

    Conserved Domains (1) summary
    pfam14988
    Location:83 → 219
    DUF4515; Domain of unknown function (DUF4515)

RNA

  1. XR_001780493.3 RNA Sequence

  2. XR_003950087.2 RNA Sequence

  3. XR_381551.5 RNA Sequence

  4. XR_381550.4 RNA Sequence

  5. XR_001780492.3 RNA Sequence

  6. XR_381548.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3V079.2 GenPept UniProtKB/Swiss-Prot:Q3V079

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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