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Ppp1r16a protein phosphatase 1, regulatory subunit 16A [ Mus musculus (house mouse) ]

Gene ID: 73062, updated on 4-Jan-2025

Summary

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Official Symbol
Ppp1r16aprovided by MGI
Official Full Name
protein phosphatase 1, regulatory subunit 16Aprovided by MGI
Primary source
MGI:MGI:1920312
See related
Ensembl:ENSMUSG00000033819 AllianceGenome:MGI:1920312
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mypt3; 2900084E10Rik
Summary
Predicted to enable enzyme inhibitor activity and myosin phosphatase regulator activity. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human PPP1R16A (protein phosphatase 1 regulatory subunit 16A). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in duodenum adult (RPKM 50.6), small intestine adult (RPKM 34.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ppp1r16a in Genome Data Viewer
Location:
15 D3; 15 36.25 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76555843..76579119)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76671643..76694919)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57852 Neighboring gene STARR-positive B cell enhancer ABC_E9419 Neighboring gene STARR-positive B cell enhancer ABC_E3145 Neighboring gene transmembrane protein 276 Neighboring gene kinesin family member C2 Neighboring gene STARR-positive B cell enhancer ABC_E5491 Neighboring gene forkhead box H1 Neighboring gene STARR-seq mESC enhancer starr_39060 Neighboring gene glutamic pyruvic transaminase, soluble Neighboring gene major facilitator superfamily domain containing 3 Neighboring gene RecQ protein-like 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PPP1R16A, the membrane subunit of protein phosphatase 1beta, signals nuclear translocation of the nuclear receptor constitutive active/androstane receptor. Sueyoshi T, et al. Mol Pharmacol, 2008 Apr. PMID 18202305
  2. Cloning and identification of MYPT3: a prenylatable myosin targetting subunit of protein phosphatase 1. Skinner JA, et al. Biochem J, 2001 May 15. PMID 11336659, Free PMC Article
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. R16A at the membrane may mediate the PB signal to initiate CAR nuclear translocation, through a mechanism including its dimerization and inhibition of PP1beta activity.
    Title: PPP1R16A, the membrane subunit of protein phosphatase 1beta, signals nuclear translocation of the nuclear receptor constitutive active/androstane receptor.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables myosin phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase regulator activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein phosphatase 1 regulatory subunit 16A
Names
mFLJ00392 protein
myosin phosphatase targeting subunit 3
myosin phosphatase, target subunit 3
protein phosphatase 1, regulatory (inhibitor) subunit 16A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358933.1 → NP_001345862.1  protein phosphatase 1 regulatory subunit 16A

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC156550
    Consensus CDS
    CCDS27585.1
    UniProtKB/Swiss-Prot
    Q4V9Z1, Q923M0
    UniProtKB/TrEMBL
    Q3TB53
    Related
    ENSMUSP00000155515.2, ENSMUST00000135388.3
    Conserved Domains (3) summary
    COG0666
    Location:138 → 328
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:98 → 285
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:74 → 101
    ANK; ANK repeat [structural motif]

  2. NM_033371.3 → NP_203535.1  protein phosphatase 1 regulatory subunit 16A

    See identical proteins and their annotated locations for NP_203535.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC156550
    Consensus CDS
    CCDS27585.1
    UniProtKB/Swiss-Prot
    Q4V9Z1, Q923M0
    UniProtKB/TrEMBL
    Q3TB53
    Related
    ENSMUSP00000037356.9, ENSMUST00000037551.15
    Conserved Domains (3) summary
    COG0666
    Location:138 → 328
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:98 → 285
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:74 → 101
    ANK; ANK repeat [structural motif]

RNA

  1. NR_152559.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most zexpected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC156550
    Related
    ENSMUST00000150399.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    76555843..76579119
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q923M0.1 GenPept UniProtKB/Swiss-Prot:Q923M0

Gene LinkOut

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