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C2cd6 C2 calcium dependent domain containing 6 [ Mus musculus (house mouse) ]

Gene ID: 73463, updated on 17-Aug-2024

Summary

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Official Symbol
C2cd6provided by MGI
Official Full Name
C2 calcium dependent domain containing 6provided by MGI
Primary source
MGI:MGI:1920713
See related
Ensembl:ENSMUSG00000072295 AllianceGenome:MGI:1920713
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C2cd6b; Gm33589; Als2cr11; Als2cr11b; 1700052H20Rik; 4930408G06Rik
Summary
Orthologous to human C2CD6 (C2 calcium dependent domain containing 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 30.5) See more
Orthologs
human all
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Genomic context

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Location:
1 C1.3; 1 29.2 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (59036275..59134283, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (58997116..59095023, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 28802 Neighboring gene STARR-seq mESC enhancer starr_01024 Neighboring gene STARR-seq mESC enhancer starr_01025 Neighboring gene trafficking protein, kinesin binding 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:59013204-59013435 Neighboring gene STARR-seq mESC enhancer starr_01027 Neighboring gene STARR-positive B cell enhancer ABC_E982 Neighboring gene STE20-related kinase adaptor beta Neighboring gene STARR-seq mESC enhancer starr_01029 Neighboring gene predicted gene 29018 Neighboring gene predicted gene, 25502 Neighboring gene transmembrane protein 237 Neighboring gene STARR-seq mESC enhancer starr_01030 Neighboring gene membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) Neighboring gene predicted gene, 19125

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. C2CD6 regulates targeting and organization of the CatSper calcium channel complex in sperm flagella. Yang F, et al. Development, 2022 Jan 15. PMID 34919125, Free PMC Article
  2. C2cd6-encoded CatSperτ targets sperm calcium channel to Ca(2+) signaling domains in the flagellar membrane. Hwang JY, et al. Cell Rep, 2022 Jan 18. PMID 34998468, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sperm capacitation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport to the plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of CatSper complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in sperm principal piece IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm principal piece ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cation channel sperm-associated targeting subunit tau
Names
C2 calcium dependent domain containing 6B
C2 calcium-dependent domain-containing protein 6
C2CD6 long isoform
amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11
amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11B
catSper-tau

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026600.1 → NP_080876.1  cation channel sperm-associated targeting subunit tau isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC133162, AC169382
    Consensus CDS
    CCDS87833.1
    UniProtKB/Swiss-Prot
    A0A5F8MPU3, E9Q152
    Related
    ENSMUSP00000159118.2, ENSMUST00000238949.2
    Conserved Domains (2) summary
    PTZ00108
    Location:739 → 997
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    pfam15729
    Location:128 → 533
    ALS2CR11; Amyotrophic lateral sclerosis 2 candidate 11

  2. NM_175200.4 → NP_780409.2  cation channel sperm-associated targeting subunit tau isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK076617, BB614746
    Consensus CDS
    CCDS14982.2
    UniProtKB/TrEMBL
    E9Q152, Q8C639
    Related
    ENSMUSP00000094845.4, ENSMUST00000097080.4
    Conserved Domains (1) summary
    pfam15729
    Location:128 → 533
    ALS2CR11; Amyotrophic lateral sclerosis 2 candidate 11

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    59036275..59134283 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313438.2 → XP_017168927.1  cation channel sperm-associated targeting subunit tau isoform X4

    Conserved Domains (1) summary
    NF000535
    Location:102 → 350
    MSCRAMM_SdrC; MSCRAMM family adhesin SdrC

  2. XM_011238636.3 → XP_011236938.1  cation channel sperm-associated targeting subunit tau isoform X3

    See identical proteins and their annotated locations for XP_011236938.1

    Conserved Domains (1) summary
    NF000535
    Location:102 → 350
    MSCRAMM_SdrC; MSCRAMM family adhesin SdrC

  3. XM_011238635.3 → XP_011236937.1  cation channel sperm-associated targeting subunit tau isoform X2

    Conserved Domains (1) summary
    COG5099
    Location:181 → 436
    COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]

  4. XM_011238634.3 → XP_011236936.1  cation channel sperm-associated targeting subunit tau isoform X1

    Conserved Domains (1) summary
    PTZ00108
    Location:202 → 460
    PTZ00108; DNA topoisomerase 2-like protein; Provisional

  5. XM_011238605.4 → XP_011236907.1  cation channel sperm-associated targeting subunit tau isoform X5

    Conserved Domains (1) summary
    pfam15729
    Location:128 → 534
    ALS2CR11; Amyotrophic lateral sclerosis 2 candidate 11

  6. XM_030243180.1 → XP_030099040.1  cation channel sperm-associated targeting subunit tau isoform X7

    UniProtKB/TrEMBL
    Q8C639
    Conserved Domains (1) summary
    pfam15729
    Location:29 → 434
    ALS2CR11; Amyotrophic lateral sclerosis 2 candidate 11

  7. XM_017312469.1 → XP_017167958.1  cation channel sperm-associated targeting subunit tau isoform X6

    UniProtKB/TrEMBL
    Q8C639
    Conserved Domains (1) summary
    pfam15729
    Location:29 → 435
    ALS2CR11; Amyotrophic lateral sclerosis 2 candidate 11
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A5F8MPU3.1 GenPept UniProtKB/Swiss-Prot:A0A5F8MPU3

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