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Vgll3 vestigial like family member 3 [ Mus musculus (house mouse) ]

Gene ID: 73569, updated on 9-Aug-2024

Summary

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Official Symbol
Vgll3provided by MGI
Official Full Name
vestigial like family member 3provided by MGI
Primary source
MGI:MGI:1920819
See related
Ensembl:ENSMUSG00000091243 AllianceGenome:MGI:1920819
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Vgl-3; Vito-2; 4832416J22; 1700110N18Rik
Summary
Enables protein C-terminus binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including genitourinary system; heart; nervous system; skeletal musculature; and somite. Orthologous to human VGLL3 (vestigial like family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 3.1), lung adult (RPKM 2.9) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Vgll3 in Genome Data Viewer
Location:
16 C1.3; 16 37.34 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (65612075..65663254)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (65815189..65866368)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41470 Neighboring gene G protein pathway suppressor 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_41174 Neighboring gene STARR-seq mESC enhancer starr_41175 Neighboring gene epidermal growth factor pseudogene Neighboring gene high mobility group box 1-like pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Vestigial-Like 3 Plays an Important Role in Osteoblast Differentiation by Regulating the Expression of Osteogenic Transcription Factors and BMP Signaling. Yuan H, et al. Calcif Tissue Int, 2022 Sep. PMID 35750933
  2. The female-biased factor VGLL3 drives cutaneous and systemic autoimmunity. Billi AC, et al. JCI Insight, 2019 Apr 18. PMID 30996136, Free PMC Article
  3. VGLL3 confers slow-twitch muscle differentiation via PGC-1α expression in C2C12 myocytes. Takakura Y, et al. Biochem Biophys Res Commun, 2023 Aug 20. PMID 37262950
  4. VGLL3 is a mechanosensitive protein that promotes cardiac fibrosis through liquid-liquid phase separation. Horii Y, et al. Nat Commun, 2023 Feb 8. PMID 36754961, Free PMC Article
  5. lncRNA Vgll3 Regulates the Activated Proliferation of Mouse Myocardial Fibroblasts through TGF-β3-Related Pathway. Liu B, et al. Biomed Res Int, 2022. PMID 36046460, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. VGLL3 confers slow-twitch muscle differentiation via PGC-1alpha expression in C2C12 myocytes.
    Title: VGLL3 confers slow-twitch muscle differentiation via PGC-1α expression in C2C12 myocytes.
  2. VGLL3 is a mechanosensitive protein that promotes cardiac fibrosis through liquid-liquid phase separation.
    Title: VGLL3 is a mechanosensitive protein that promotes cardiac fibrosis through liquid-liquid phase separation.
  3. Vestigial-Like 3 Plays an Important Role in Osteoblast Differentiation by Regulating the Expression of Osteogenic Transcription Factors and BMP Signaling.
    Title: Vestigial-Like 3 Plays an Important Role in Osteoblast Differentiation by Regulating the Expression of Osteogenic Transcription Factors and BMP Signaling.
  4. Study demonstrated that skin-directed overexpression of murine female-biased factor VGLL3 causes a severe lupus-like rash and systemic autoimmune disease that involves B cell expansion, autoantibody production, immune complex deposition, and end-organ damage. Results strongly implicate VGLL3 as a pivotal orchestrator of sex-biased autoimmunity.
    Title: The female-biased factor VGLL3 drives cutaneous and systemic autoimmunity.
  5. Loss of VGLL3 expression was observed in tumors derived from mouse xenograft models.
    Title: VGLL3 expression is associated with a tumor suppressor phenotype in epithelial ovarian cancer.
  6. vestigial-like 3 (Vgll3) is an inhibitor of adipogenesis
    Title: Vestigial-like 3 is an inhibitor of adipocyte differentiation.
  7. In embryonic and fetal development VITO-2 is mainly expressed in the myogenic lineage.Later developmental stages it is found in the nervous system.In adult mice it was detected in skeletal muscle, heart, kidney, liver, brain.
    Title: VITO-2, a new SID domain protein, is expressed in the myogenic lineage during early mouse embryonic development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3)  1 citation
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transcription cofactor vestigial-like protein 3
Names
vestigial like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368760.1 → NP_001355689.1  transcription cofactor vestigial-like protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    CT010565
    UniProtKB/Swiss-Prot
    P85442
    Conserved Domains (1) summary
    pfam07545
    Location:85 → 115
    Vg_Tdu; Vestigial/Tondu family

  2. NM_001368761.1 → NP_001355690.1  transcription cofactor vestigial-like protein 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    CT010565
    Consensus CDS
    CCDS88949.1
    UniProtKB/TrEMBL
    A0A2I3BPM3
    Related
    ENSMUSP00000153843.2, ENSMUST00000227997.2
    Conserved Domains (1) summary
    pfam07545
    Location:42 → 59
    Vg_Tdu; Vestigial/Tondu family

  3. NM_028572.2 → NP_082848.1  transcription cofactor vestigial-like protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT010565
    Consensus CDS
    CCDS49884.1
    UniProtKB/TrEMBL
    E9Q1Y1
    Related
    ENSMUSP00000131500.2, ENSMUST00000168064.3
    Conserved Domains (1) summary
    pfam07545
    Location:84 → 114
    Vg_Tdu; Vestigial/Tondu family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    65612075..65663254
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P85442.1 GenPept UniProtKB/Swiss-Prot:P85442

Gene LinkOut

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