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Xpo6 exportin 6 [ Mus musculus (house mouse) ]

Gene ID: 74204, updated on 17-Aug-2024

Summary

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Official Symbol
Xpo6provided by MGI
Official Full Name
exportin 6provided by MGI
Primary source
MGI:MGI:2429950
See related
Ensembl:ENSMUSG00000000131 AllianceGenome:MGI:2429950
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
exp6; Ranbp20; mKIAA0370; 2610005L19Rik; C230091E20Rik
Summary
Predicted to enable nuclear export signal receptor activity. Involved in protein export from nucleus. Predicted to be located in cytosol; nuclear lumen; and plasma membrane. Predicted to be part of protein-containing complex. Orthologous to human XPO6 (exportin 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 61.3), thymus adult (RPKM 29.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 F3; 7 69.01 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (125700890..125799715, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126101718..126200539, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene katanin interacting protein Neighboring gene VISTA enhancer mm174 Neighboring gene STARR-seq mESC enhancer starr_20126 Neighboring gene GSG1-like Neighboring gene predicted gene, 51456 Neighboring gene STARR-seq mESC enhancer starr_20127 Neighboring gene STARR-seq mESC enhancer starr_20131 Neighboring gene LAG1 homolog, ceramide synthase 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_20132 Neighboring gene RIKEN cDNA 1700123J17 gene Neighboring gene STARR-seq mESC enhancer starr_20133 Neighboring gene STARR-seq mESC enhancer starr_20134 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133373927-133374110 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Active maintenance of nuclear actin by importin 9 supports transcription. Dopie J, et al. Proc Natl Acad Sci U S A, 2012 Feb 28. PMID 22323606, Free PMC Article
  2. ZMPSTE24 defends against influenza and other pathogenic viruses. Fu B, et al. J Exp Med, 2017 Apr 3. PMID 28246125, Free PMC Article
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2002 Oct 31. PMID 12465718
  4. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Exportin XPO6 upregulation activates the TLR2/MyD88/NF-kappaB signaling by facilitating TLR2 mRNA nuclear export in COPD pulmonary monocytes.
    Title: Exportin XPO6 upregulation activates the TLR2/MyD88/NF-κB signaling by facilitating TLR2 mRNA nuclear export in COPD pulmonary monocytes.
  2. Measurements of nuclear export rates and depletion studies clarified that nuclear export of actin is mediated by exportin 6.
    Title: Active maintenance of nuclear actin by importin 9 supports transcription.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nuclear export signal receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in protein export from nucleus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
exportin-6
Names
RAN binding protein 20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311143.2 → NP_001298072.1  exportin-6 isoform 1

    See identical proteins and their annotated locations for NP_001298072.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC012297, AC135809
    Consensus CDS
    CCDS80800.1
    UniProtKB/Swiss-Prot
    Q3U3K7, Q6PEF3, Q924Z6, Q9D0K9
    Related
    ENSMUSP00000130527.2, ENSMUST00000168189.8
    Conserved Domains (2) summary
    smart00913
    Location:31 → 96
    IBN_N; Importin-beta N-terminal domain
    pfam08389
    Location:103 → 277
    Xpo1; Exportin 1-like protein

  2. NM_028816.3 → NP_083092.2  exportin-6 isoform 2

    See identical proteins and their annotated locations for NP_083092.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
    Source sequence(s)
    AC135809, BC058090, BU708634
    Consensus CDS
    CCDS52396.1
    UniProtKB/Swiss-Prot
    Q924Z6
    Related
    ENSMUSP00000009344.10, ENSMUST00000009344.16
    Conserved Domains (2) summary
    smart00913
    Location:31 → 96
    IBN_N; Importin-beta N-terminal domain
    pfam08389
    Location:103 → 277
    Xpo1; Exportin 1-like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    125700890..125799715 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312342.3 → XP_017167831.1  exportin-6 isoform X2

    Conserved Domains (2) summary
    smart00913
    Location:31 → 96
    IBN_N; Importin-beta N-terminal domain
    pfam08389
    Location:103 → 277
    Xpo1; Exportin 1-like protein

  2. XM_017312341.3 → XP_017167830.1  exportin-6 isoform X1

    Conserved Domains (2) summary
    smart00913
    Location:31 → 96
    IBN_N; Importin-beta N-terminal domain
    pfam08389
    Location:103 → 277
    Xpo1; Exportin 1-like protein

  3. XM_006508250.2 → XP_006508313.1  exportin-6 isoform X4

    UniProtKB/TrEMBL
    Q8CHG0

  4. XM_036153494.1 → XP_036009387.1  exportin-6 isoform X5

    UniProtKB/TrEMBL
    Q8CHG0

  5. XM_036153493.1 → XP_036009386.1  exportin-6 isoform X3

    UniProtKB/TrEMBL
    Q8CHG0

  6. XM_017312345.3 → XP_017167834.1  exportin-6 isoform X6

    UniProtKB/TrEMBL
    Q8CHG0
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q924Z6.2 GenPept UniProtKB/Swiss-Prot:Q924Z6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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