Spmip9 sperm microtubule inner protein 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Spmip9provided by MGI
Official Full Name: sperm microtubule inner protein 9provided by MGI
Primary source: MGI:MGI:1921471
See related: Ensembl:ENSMUSG00000051896 AllianceGenome:MGI:1921471
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tex37; Tsc21; 1700011F03Rik
Summary: Involved in flagellated sperm motility. Is active in axonemal A tubule inner sheath and sperm flagellum. Orthologous to human SPMIP9 (sperm microtubule inner protein 9). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Restricted expression toward testis adult (RPKM 105.0) See more
Orthologs: human all
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Genomic context

Location:: 6 C1; 6 32.12 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (70890073..70928078, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (70913089..70951095, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study of the mouse Tex37 and Prss55 - genes evolutionarily conserved in eutherians (including human) found that these genes had a testis-enriched expression pattern in mice, but they are not individually essential for spermatogenesis, testis development and male fertility in mice in laboratory conditions.
Title: The evolutionarily conserved genes: Tex37, Ccdc73, Prss55 and Nxt2 are dispensable for fertility in mice.
Identification of a novel gene, Tsc21, exclusively expressed in testes.
Title: Identification and characteristics of a novel testis-specific gene, Tsc21, in mice and human.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in flagellated sperm motility	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in axonemal A tubule inner sheath	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in sperm flagellum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein SPMIP9

Names: protein TSC21; testis expressed 37; testis-expressed sequence 37 protein; testis-specific conserved protein of 21 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355766.1 → NP_001342695.1 protein SPMIP9 isoform 2

Status: VALIDATED

Source sequence(s)

AK005862

Conserved Domains (1) summary

pfam15217
Location:1 → 179

TSC21; TSC21 family
NM_028825.3 → NP_083101.1 protein SPMIP9 isoform 1

See identical proteins and their annotated locations for NP_083101.1

Status: VALIDATED

Source sequence(s)

AK005862

Consensus CDS

CCDS20224.1

UniProtKB/Swiss-Prot

Q810N1, Q9DAG4

Related

ENSMUSP00000066786.5, ENSMUST00000063456.5

Conserved Domains (1) summary

pfam15217
Location:1 → 180

TSC21; TSC21 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

70890073..70928078 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030255637.2 → XP_030111497.1 protein SPMIP9 isoform X2

Conserved Domains (1) summary

pfam15217
Location:34 → 213

TSC21; TSC21 family
XM_030255636.1 → XP_030111496.1 protein SPMIP9 isoform X1

Conserved Domains (1) summary

pfam15217
Location:1 → 179

TSC21; TSC21 family